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View Structure Prediction Details

Protein: kap104
Organism: Schizosaccharomyces pombe
Length: 910 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for kap104.

Description E-value Query
Range
Subject
Range
gi|109123651 - gi|109123651|ref|XP_001109480.1| PREDICTED: similar to transportin 2 (importin 3, karyopherin beta 2...
514.0 [0..6] [910..211]
gi|109465974 - gi|109465974|ref|XP_001070389.1| PREDICTED: similar to transportin 1 [Rattus norvegicus]
513.0 [0..3] [910..247]
gi|114675523 - gi|114675523|ref|XP_512411.2| PREDICTED: transportin 2 (importin 3, karyopherin beta 2b) [Pan troglo...
506.0 [0..6] [910..176]
gi|68533077 - gi|68533077|dbj|BAE06093.1| TNPO2 variant protein [Homo sapiens]
505.0 [0..6] [910..167]
gi|48095991, gi|... - ref|XP_392373.1| similar to transportin 1; karyopherin (importin) beta 2 [Apis mellifera], gi|110756...
488.0 [0..5] [910..38]
gi|91092132 - gi|91092132|ref|XP_975744.1| PREDICTED: similar to transportin 1 isoform 2 [Tribolium castaneum]
486.0 [0..6] [910..5]
gi|27819795 - gi|27819795|gb|AAO24946.1| RE59670p [Drosophila melanogaster]
482.0 [0..6] [910..3]
TNPO1_MOUSE - Transportin-1 OS=Mus musculus GN=Tnpo1 PE=1 SV=2
481.0 [0..3] [910..10]

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Predicted Domain #1
Region A:
Residues: [1-910]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGDNPWVLQE QVLVELSEVI KNSLSENSQT RNAALNLLEK AKDIPDLNNY LTCILINATE  60
   61 LSVSIRSAAG LLLKNNVRVS SLESGSGLQS LDYTKSTVIR GLCDPEQLIR GISGNVITTI 120
  121 ISRWGISTWP EVLPQLMEML SSPASTTQEG AFSALTKICE DSAQELDRDF NGTRPLDFMI 180
  181 PRFIELARHE NPKIRTDALF CLNQFVLIQS QSLYAHIDTF LETCYALATD VSPNVRKNVC 240
  241 QALVYLLDVR PDKIAPSLGS IVEYMLYSTQ DSDQNVALEA CEFWLAIAEQ PDLCSALGPY 300
  301 LDKIVPMLLQ GMVYSDMDLL LLGNDADDYD VEDREEDIRP QHAKGKSRIT LNTQGPITQQ 360
  361 GSSNADADEL EDEDEDDDEF DEDDDAFMDW NLRKCSAAAL DVLSSFWKQR LLEIILPHLK 420
  421 QSLTSEDWKV QEAGVLAVGA IAEGCMDGMV QYLPELYPYF LSLLDSKKPL VRTITCWTLG 480
  481 RYSKWASCLE SEEDRQKYFV PLLQGLLRMV VDNNKKVQEA GCSAFAILEE QAGPSLVPYL 540
  541 EPILTNLAFA FQKYQRKNVL ILYDAVQTLA DYVGSALNDK RYIELLITPL LQKWSMIPDD 600
  601 DPNLFPLFEC LSSVAVALRD GFAPFAAETY ARTFRILRNT LYLITTAQND PTVDVPDRDF 660
  661 LVTTLDLVSG IIQALGSQVS PLLAQADPPL GQIIGICAKD EVPEVRQSAY ALLGDMCMYC 720
  721 FDQIRPYCDA LLVDMLPQMQ LPLLHVSASN NAIWSAGEMA LQLGKDMQQW VKPLLERLIC 780
  781 ILKSKKSNTT VLENVAITIG RLGVYNPELV APHLELFYQP WFEIIKTVGE NEEKDSAFRG 840
  841 FCNILACNPQ ALSYLLPMFV LCVAEYENPS AELRDMFQKI LQGSVELFNG KASWQASPEV 900
  901 LAQIQAQYGV 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 136.0
Match: 1qbkB
Description: Karyopherin beta2
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
protein transporter activity 4.58709163830613 bayes_pls_golite062009
binding 3.0667965351474 bayes_pls_golite062009
protein transmembrane transporter activity 2.74547353635661 bayes_pls_golite062009
transporter activity 2.48700774379895 bayes_pls_golite062009
nucleic acid binding 2.34284977509828 bayes_pls_golite062009
substrate-specific transporter activity 2.26725422172281 bayes_pls_golite062009
nuclear localization sequence binding 1.91487015967262 bayes_pls_golite062009
transcription regulator activity 1.76231475025891 bayes_pls_golite062009
protein binding 1.73688475473996 bayes_pls_golite062009
DNA binding 1.62032607987786 bayes_pls_golite062009
nuclear export signal receptor activity 1.29390474721722 bayes_pls_golite062009
transmembrane transporter activity 1.28481004323799 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 1.09652988954158 bayes_pls_golite062009
transcription factor activity 0.923253759652909 bayes_pls_golite062009
structural molecule activity 0.908029258648777 bayes_pls_golite062009
translation initiation factor activity 0.83079633551839 bayes_pls_golite062009
translation regulator activity 0.82193201542158 bayes_pls_golite062009
translation factor activity, nucleic acid binding 0.803700928110921 bayes_pls_golite062009
molecular transducer activity 0.662662274021266 bayes_pls_golite062009
signal transducer activity 0.662662274021266 bayes_pls_golite062009
signal sequence binding 0.57106697498903 bayes_pls_golite062009
mRNA binding 0.46864854653143 bayes_pls_golite062009
RNA binding 0.40024158562931 bayes_pls_golite062009
clathrin binding 0.35775052108553 bayes_pls_golite062009
active transmembrane transporter activity 0.252495966234234 bayes_pls_golite062009
ion transmembrane transporter activity 0.248585912061178 bayes_pls_golite062009
primary active transmembrane transporter activity 0.226380819487924 bayes_pls_golite062009
P-P-bond-hydrolysis-driven transmembrane transporter activity 0.217517113570989 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances 0.178770060806735 bayes_pls_golite062009
ATPase activity, coupled to movement of substances 0.175241020572885 bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of substances 0.174922130116569 bayes_pls_golite062009
nucleoside-triphosphatase activity 0.100181463251306 bayes_pls_golite062009
pyrophosphatase activity 0.0635404099346928 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides 0.0548082069333885 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 0.052195223119721 bayes_pls_golite062009
cation transmembrane transporter activity 0.0405268469927988 bayes_pls_golite062009
transcription activator activity 0.0232727461674547 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle