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View Structure Prediction Details

Protein: int6
Organism: Schizosaccharomyces pombe
Length: 501 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for int6.

Description E-value Query
Range
Subject
Range
gi|95769412 - gi|95769412|gb|ABF57434.1| eukaryotic translation initiation factor 3, subunit 6 48kDa [Bos taurus]
689.0 [0..13] [495..1]
gi|149721734 - gi|149721734|ref|XP_001495193.1| PREDICTED: similar to Eukaryotic translation initiation factor 3 su...
gi|73974299 - gi|73974299|ref|XP_532304.2| PREDICTED: similar to eukaryotic translation initiation factor 3, subun...
gi|109087237, gi... - gi|109087239|ref|XP_001090593.1| PREDICTED: eukaryotic translation initiation factor 3, subunit 6 48...
gi|123997605, gi... - gi|61363628|gb|AAX42420.1| eukaryotic translation initiation factor 3 subunit 6 48kDa [synthetic con...
EIF3E_MACFA - Eukaryotic translation initiation factor 3 subunit E OS=Macaca fascicularis GN=EIF3E PE=2 SV=1
EIF3E_PONAB - Eukaryotic translation initiation factor 3 subunit E OS=Pongo abelii GN=EIF3E PE=2 SV=2
ENSOCUP00000006956 - pep:novel chromosome:oryCun2:3:123577974:123623555:-1 gene:ENSOCUG00000008050 transcript:ENSOCUT0000...
EIF3E - eukaryotic translation initiation factor 3, subunit E
IF36_PONPY - Eukaryotic translation initiation factor 3 subunit 6 - Pongo pygmaeus (Orangutan)
EIF3E_MOUSE - Eukaryotic translation initiation factor 3 subunit E OS=Mus musculus GN=Eif3e PE=1 SV=1
EIF3E_RAT - Eukaryotic translation initiation factor 3 subunit E OS=Rattus norvegicus GN=Eif3e PE=2 SV=1
ENSCJAT00000012664 - null
tr|M3W0R4|M3W0R4... - Eukaryotic translation initiation factor 3 subunit E OS=Felis catus GN=EIF3E PE=3 SV=1
689.0 [0..13] [495..2]
gi|60818924 - gi|60818924|gb|AAX36482.1| eukaryotic translation initiation factor 3 subunit 6 [synthetic construct...
688.0 [0..13] [495..2]
EIF3E_CHICK - Eukaryotic translation initiation factor 3 subunit E OS=Gallus gallus GN=EIF3E PE=2 SV=1
688.0 [0..13] [495..2]
gi|55730358 - gi|55730358|emb|CAH91901.1| hypothetical protein [Pongo abelii]
gi|197098998 - gi|197098998|ref|NP_001126100.1| eukaryotic translation initiation factor 3, subunit E [Pongo abelii...
687.0 [0..13] [495..2]
EIF3E_XENTR - Eukaryotic translation initiation factor 3 subunit E OS=Xenopus tropicalis GN=eif3e PE=2 SV=1
685.0 [0..13] [495..2]

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Predicted Domain #1
Region A:
Residues: [1-149]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGSELKSTSP LAVKYDLSQK IMQHLDRHLI FPLLEFLSLR QTHDPKELLQ AKYDLLKDTN  60
   61 MTDYVANLWT NLHGGHTDED MANAFAEKRR SVLQELSELE EEVQGILGVL ENPDLIAALR 120
  121 QDKGQNLQHL QEHYNITPER IAVLYKFAQ

[Run NCBI BLAST on this sequence.]

Detection Method: Pfam
Confidence: 80.958607
Match: PF09440.1
Description: No description for PF09440.1 was found.

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [150-282]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FQYNCGNYGG ASDLLYHFRA FSKDPELNAS ATWGKFASEI LTVDWDGAME ELGKLREMVD  60
   61 SKSFKDSAVQ LRNRTWLLHW SLFPLFNHAN GCDTLCDLFF YTPYLNTIQT SCPWLLRYLT 120
  121 VAVVTNQNNA NQK

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [283-360]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PRNPRQSYQR RMRDLVRIIS QENYEYSDPV TSFISALYTE VDFEKAQHCL RECEEVLKTD  60
   61 FFLVSLCDHF LEGARKLL

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [361-501]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 AEAYCRIHSV ISVDVLANKL EMDSAQLIQL VENRNNPSVA AASNVAADQS TEDESIESTS  60
   61 TNVVADDLIT EAETATEAEE PEPEVQFGFK AKLDGESIII EHPTYSAFQQ IIDRTKSLSF 120
  121 ESQNLEQSLA KSISELKHAT V

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 3.17
Match: 1ufmA
Description: Solution structure of the PCI domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 3.40627040093952 bayes_pls_golite062009
DNA binding 3.18517869180019 bayes_pls_golite062009
structural constituent of ribosome 2.974370828939 bayes_pls_golite062009
nucleic acid binding 2.8293727459515 bayes_pls_golite062009
binding 2.73671056234733 bayes_pls_golite062009
structural molecule activity 2.72616711594099 bayes_pls_golite062009
transcription factor activity 2.51227631362049 bayes_pls_golite062009
transcription activator activity 2.04243540203739 bayes_pls_golite062009
sequence-specific DNA binding 1.96901349910727 bayes_pls_golite062009
protein binding 1.77689943618029 bayes_pls_golite062009
transcription repressor activity 0.811726311475138 bayes_pls_golite062009
RNA binding 0.352569950847387 bayes_pls_golite062009
hydrolase activity 0.20695163916851 bayes_pls_golite062009
ubiquitin-protein ligase activity 0.142921675412538 bayes_pls_golite062009
small conjugating protein ligase activity 0.124542865343065 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle