YRC Public Data Repository - Protein Structure Prediction

Protein:	SPCC13B11.04c
Organism:	Schizosaccharomyces pombe
Length:	380 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SPCC13B11.04c.

Description	E-value	Query Range	Subject Range
gi\|157278309, gi... - gi\|42412381\|gb\|AAS15570.1\| class III alcohol dehydrogenase [Oryzias latipes], gi\|157278309\|ref\|NP_00...	412.0	[0..4]	[379..1]
gi\|238715026, gi... - gi\|77958654\|ref\|ZP_00822684.1\| COG1062: Zn-dependent alcohol dehydrogenases, class III [Yersinia ber...	410.0	[0..10]	[379..3]
gi\|46195771, gi\|... - gi\|46195771\|ref\|NP_571924.2\| class III alcohol dehydrogenase, chi subunit [Danio rerio], gi\|45595752...	410.0	[0..4]	[379..1]
gi\|238727202, gi... - gi\|77978816\|ref\|ZP_00834240.1\| COG1062: Zn-dependent alcohol dehydrogenases, class III [Yersinia int...	410.0	[0..9]	[379..2]
gi\|238788842, gi... - gi\|77973854\|ref\|ZP_00829398.1\| COG1062: Zn-dependent alcohol dehydrogenases, class III [Yersinia fre...	406.0	[0..10]	[379..3]
ADHX_SPAAU - Alcohol dehydrogenase class-3 OS=Sparus aurata PE=2 SV=1	406.0	[0..4]	[379..1]
gi\|54308673, gi\|... - gi\|54308673\|ref\|YP_129693.1\| putative alcohol dehydrogenase class III [Photobacterium profundum SS9]...	406.0	[0..7]	[379..2]
gi\|160861160, gi... - gi\|160875638\|ref\|YP_001554954.1\| S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydr... gi\|68542288, gi\|... - gi\|68542288\|ref\|ZP_00582021.1\| Zinc-containing alcohol dehydrogenase superfamily [Shewanella baltica... gi\|77816052, gi\|... - gi\|77816052\|ref\|ZP_00815261.1\| Zinc-containing alcohol dehydrogenase superfamily [Shewanella putrefa... gi\|153000927, gi... - gi\|153000927\|ref\|YP_001366608.1\| S-(hydroxymethyl)glutathione dehydrogenase [Shewanella baltica OS18... gi\|146863790, gi... - gi\|217973117\|ref\|YP_002357868.1\| S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydr...	405.0	[0..3]	[379..1]
gi\|90325090, gi\|... - gi\|90413906\|ref\|ZP_01221892.1\| putative alcohol dehydrogenase class III [Photobacterium profundum 3T...	405.0	[0..7]	[379..2]

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Predicted Domain #1

Region A:
Residues: [1-380]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MQQSPTAGKI INCKAAVAWQ PAAPLSIENV QVFPPRVHEV RIKIVNSGVC HTDAYTLSGK  60
   61 DPEGLFPVIL GHEGAGIVES VGPQVTTVQV GDPVIALYTP ECKTCKFCKS GKTNLCGRIR 120
  121 TTQGKGLMPD GTSRFSCNGN TLLHFMGCST FSEYTVVADI SVVAIERLAP LDSVCLLGCG 180
  181 ITTGYGAATI TADIKEGDSV AVFGLGSVGL AVIQGAVKKR AGRIFGIDVN PEKKNWAMSF 240
  241 GATDFINPND LQSPIQDVLI HETDGGLDWT FDCTGNVHVM RSALEACHKG WGQSIVIGVA 300
  301 AAGQEISTRP FQLVTGRVWR GCAFGGVKGR SQLPDLVKEY LDHKLEIDKY ITHRRPLKEI 360
  361 NEAFTDMHNG NCIKTVLSIP

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	107.0
Match:	1m6hA
Description:	Alcohol dehydrogenase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
ethanol binding	4.47659026306883	bayes_pls_golite062009
NAD or NADH binding	4.35058438816264	bayes_pls_golite062009
retinol dehydrogenase activity	4.1750549780559	bayes_pls_golite062009
oxidoreductase activity	3.09625241707629	bayes_pls_golite062009
methylglyoxal reductase (NADH-dependent) activity	3.00190838171391	bayes_pls_golite062009
alcohol binding	2.97042200128883	bayes_pls_golite062009
alcohol dehydrogenase (NAD) activity	2.94416173750168	bayes_pls_golite062009
retinol binding	2.89007863838685	bayes_pls_golite062009
all-trans retinal binding	2.84803957533249	bayes_pls_golite062009
S-(hydroxymethyl)glutathione dehydrogenase activity	2.58673703881996	bayes_pls_golite062009
hydroxymethylfurfural reductase (NADH) activity	2.2999175117758	bayes_pls_golite062009
hydroxymethylfurfural reductase activity	2.2999175117758	bayes_pls_golite062009
alcohol dehydrogenase activity, zinc-dependent	2.26153457113968	bayes_pls_golite062009
NADPH:quinone reductase activity	2.16668841986245	bayes_pls_golite062009
benzaldehyde dehydrogenase activity	2.03039843216597	bayes_pls_golite062009
catalytic activity	1.79741889688267	bayes_pls_golite062009
oxidoreductase activity, acting on CH-OH group of donors	1.65338499044318	bayes_pls_golite062009
DNA binding	1.61355789916908	bayes_pls_golite062009
transcription regulator activity	1.55390653047158	bayes_pls_golite062009
nucleic acid binding	1.48478425318425	bayes_pls_golite062009
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	1.47309297191111	bayes_pls_golite062009
oxidoreductase activity, acting on the CH-CH group of donors	1.38219425408212	bayes_pls_golite062009
oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor	1.29842732066898	bayes_pls_golite062009
chaperone binding	1.19079350615542	bayes_pls_golite062009
3-hydroxyacyl-CoA dehydrogenase activity	1.07006097264025	bayes_pls_golite062009
oxidoreductase activity, acting on NADH or NADPH	1.01627645289834	bayes_pls_golite062009
binding	0.982999356179965	bayes_pls_golite062009
transcription factor activity	0.91090893050278	bayes_pls_golite062009
monovalent inorganic cation transmembrane transporter activity	0.527946013169731	bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor	0.484089941059577	bayes_pls_golite062009
kinase activity	0.461063813999598	bayes_pls_golite062009
hydroxymethylfurfural reductase (NADPH) activity	0.382131941157781	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	0.375415252607746	bayes_pls_golite062009
coenzyme binding	0.35922330382799	bayes_pls_golite062009
structural molecule activity	0.345975336806588	bayes_pls_golite062009
protein kinase activity	0.339420053437627	bayes_pls_golite062009
3-alpha(17-beta)-hydroxysteroid dehydrogenase (NAD+) activity	0.320177384202291	bayes_pls_golite062009
enoyl-CoA hydratase activity	0.250698007650211	bayes_pls_golite062009
methylenetetrahydrofolate dehydrogenase activity	0.169301675015808	bayes_pls_golite062009
methenyltetrahydrofolate cyclohydrolase activity	0.162625185692811	bayes_pls_golite062009
fatty acid synthase activity	0.0962368786590111	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: