YRC Public Data Repository - Protein Structure Prediction

Protein:	tms1
Organism:	Schizosaccharomyces pombe
Length:	360 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for tms1.

Description	E-value	Query Range	Subject Range
XYL2_EMENI - Probable D-xylulose reductase A OS=Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / N... XYL2_EMENI - Probable D-xylulose reductase A OS=Emericella nidulans GN=xdhA PE=3 SV=1	322.0	[0..9]	[360..14]
gi\|40795502 - gi\|40795502\|gb\|AAR91477.1\| thermostable alcohol dehydrogenase [Geobacillus sp. M10EXG]	321.0	[0..5]	[359..1]
gi\|238715026, gi... - gi\|77958654\|ref\|ZP_00822684.1\| COG1062: Zn-dependent alcohol dehydrogenases, class III [Yersinia ber...	320.0	[0..1]	[358..3]
ADH3_GEOSE - Alcohol dehydrogenase OS=Geobacillus stearothermophilus PE=1 SV=1	319.0	[0..5]	[359..1]
gi\|238727202, gi... - gi\|77978816\|ref\|ZP_00834240.1\| COG1062: Zn-dependent alcohol dehydrogenases, class III [Yersinia int...	318.0	[0..1]	[360..3]
gi\|111059978 - gi\|111059978\|gb\|EAT81098.1\| hypothetical protein SNOG_11390 [Phaeosphaeria nodorum SN15]	318.0	[0..9]	[359..14]
gi\|90325090, gi\|... - gi\|90413906\|ref\|ZP_01221892.1\| putative alcohol dehydrogenase class III [Photobacterium profundum 3T...	317.0	[0..1]	[358..1]
gi\|160861160, gi... - gi\|160875638\|ref\|YP_001554954.1\| S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydr... gi\|68542288, gi\|... - gi\|68542288\|ref\|ZP_00582021.1\| Zinc-containing alcohol dehydrogenase superfamily [Shewanella baltica... gi\|77816052, gi\|... - gi\|77816052\|ref\|ZP_00815261.1\| Zinc-containing alcohol dehydrogenase superfamily [Shewanella putrefa... gi\|153000927, gi... - gi\|153000927\|ref\|YP_001366608.1\| S-(hydroxymethyl)glutathione dehydrogenase [Shewanella baltica OS18... gi\|146863790, gi... - gi\|217973117\|ref\|YP_002357868.1\| S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydr...	317.0	[0..6]	[358..12]
gi\|238788842, gi... - gi\|77973854\|ref\|ZP_00829398.1\| COG1062: Zn-dependent alcohol dehydrogenases, class III [Yersinia fre...	316.0	[0..1]	[358..3]

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Predicted Domain #1

Region A:
Residues: [1-360]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAPAEKAFVL RKKMDTAIED RPGQTLTDDH QVKVAIKATG ICGSDVHYWK EGGIGDFILK  60
   61 KPMILGHESA GVVVEVGKGV SSLKPGDPVA VEPGCVCRLC DYCRSGRYNL CPHMEFAATP 120
  121 PYDGTLRTYY ITTEDFCTKL PKQISVEEGA LFEPMSVAVH AMTRGNLKCG SRVLVMGCGT 180
  181 VGLLMMAVAK AYGAIDIVAV DASPSRVEFA QKYVGAKPFT PIAAKENESL PDYAQRYKQA 240
  241 IIEKYGEFDF AVDATGVGIC IHTAVLALKR GGTFVQAGNG KPVIDFPINH IINYEINVLG 300
  301 SFRYAHGCYK QSLFLVSNGL VDVKPLITHR FAFKDALKAY ETVASGEEGV LKVIIGGPDA 360
  361

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	81.09691
Match:	1e3jA
Description:	Ketose reductase (sorbitol dehydrogenase)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
ethanol binding	4.47659026306883	bayes_pls_golite062009
NAD or NADH binding	4.35058438816264	bayes_pls_golite062009
retinol dehydrogenase activity	4.1750549780559	bayes_pls_golite062009
oxidoreductase activity	3.09625241707629	bayes_pls_golite062009
L-iditol 2-dehydrogenase activity	3.00103406168296	bayes_pls_golite062009
alcohol binding	2.97042200128883	bayes_pls_golite062009
alcohol dehydrogenase (NAD) activity	2.94416173750168	bayes_pls_golite062009
retinol binding	2.89007863838685	bayes_pls_golite062009
all-trans retinal binding	2.84803957533249	bayes_pls_golite062009
S-(hydroxymethyl)glutathione dehydrogenase activity	2.58673703881996	bayes_pls_golite062009
hydroxymethylfurfural reductase activity	2.2999175117758	bayes_pls_golite062009
hydroxymethylfurfural reductase (NADH) activity	2.2999175117758	bayes_pls_golite062009
alcohol dehydrogenase activity, zinc-dependent	2.26153457113968	bayes_pls_golite062009
NADPH:quinone reductase activity	2.16668841986245	bayes_pls_golite062009
benzaldehyde dehydrogenase activity	2.03039843216597	bayes_pls_golite062009
catalytic activity	1.79741889688267	bayes_pls_golite062009
oxidoreductase activity, acting on CH-OH group of donors	1.65338499044318	bayes_pls_golite062009
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	1.47309297191111	bayes_pls_golite062009
oxidoreductase activity, acting on the CH-CH group of donors	1.38219425408212	bayes_pls_golite062009
oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor	1.29842732066898	bayes_pls_golite062009
3-hydroxyacyl-CoA dehydrogenase activity	1.07006097264025	bayes_pls_golite062009
chaperone binding	1.04678886151518	bayes_pls_golite062009
retinoid binding	1.04593455330515	bayes_pls_golite062009
oxidoreductase activity, acting on NADH or NADPH	1.01627645289834	bayes_pls_golite062009
isoprenoid binding	0.93398178725124	bayes_pls_golite062009
monovalent inorganic cation transmembrane transporter activity	0.527946013169731	bayes_pls_golite062009
hydrolase activity	0.41684292392606	bayes_pls_golite062009
hydroxymethylfurfural reductase (NADPH) activity	0.382131941157781	bayes_pls_golite062009
L-arabinitol 2-dehydrogenase activity	0.382131941157781	bayes_pls_golite062009
glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) activity	0.361275519814065	bayes_pls_golite062009
coenzyme binding	0.35922330382799	bayes_pls_golite062009
binding	0.355184540089764	bayes_pls_golite062009
3-alpha(17-beta)-hydroxysteroid dehydrogenase (NAD+) activity	0.320177384202291	bayes_pls_golite062009
glyceraldehyde-3-phosphate dehydrogenase activity	0.298691872199351	bayes_pls_golite062009
ATPase activity	0.275256680720412	bayes_pls_golite062009
enoyl-CoA hydratase activity	0.250698007650211	bayes_pls_golite062009
methylenetetrahydrofolate dehydrogenase activity	0.169301675015808	bayes_pls_golite062009
methenyltetrahydrofolate cyclohydrolase activity	0.162625185692811	bayes_pls_golite062009
fatty acid synthase activity	0.0962368786590111	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: