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View Structure Prediction Details

Protein: csn1
Organism: Schizosaccharomyces pombe
Length: 422 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for csn1.

Description E-value Query
Range
Subject
Range
gi|5670324 - gi|5670324|gb|AAC50906.2| Gps1 [Homo sapiens]
297.0 [0..4] [422..49]
gi|55732991 - gi|55732991|emb|CAH93182.1| hypothetical protein [Pongo abelii]
gi|55732991|emb|... - hypothetical protein [Pongo pygmaeus]
297.0 [0..4] [422..41]
gi|67970136 - gi|67970136|dbj|BAE01412.1| unnamed protein product [Macaca fascicularis]
296.0 [0..4] [422..36]
tr|A0A0G2JW80|A0... - Isoform of P97834, COP9 signalosome complex subunit 1 OS=Rattus norvegicus GN=Gps1 PE=1 SV=1
gi|75517042 - gi|75517042|gb|AAI03783.1| G protein pathway suppressor 1 [Mus musculus]
294.0 [0..4] [422..36]
gi|76645477, gi|... - gi|76645477|ref|XP_603925.2| PREDICTED: similar to G protein pathway suppressor 1 isoform 1 [Bos tau...
292.0 [0..4] [422..20]

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Predicted Domain #1
Region A:
Residues: [1-88]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSLNLLVNQE ELKRYLDEYG VWSKIFRALF VARNSKPLRS FCVHYAIKEL KEKTYNLELY  60
   61 QSLFEEFQDC FENEQLDVEW VESVTFHR

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.764 0.162 cytosol f.1.4 Bcl-2 inhibitors of programmed cell death
View Download 0.719 0.037 regulation of DNA replication a.27.1 Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
View Download 0.620 0.019 regulation of DNA replication a.24.13 Domain of the SRP/SRP receptor G-proteins
View Download 0.738 0.012 regulation of DNA replication d.8.1 Urease, gamma-subunit
View Download 0.748 N/A N/A f.1.4 Bcl-2 inhibitors of programmed cell death

Predicted Domain #2
Region A:
Residues: [89-239]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KQNLEQLRRE LKAYKNNLIR ESIRAAQLDL ASFFADVGQF DSALRSYAKV REYCTNAGQI  60
   61 AHLSLELMRI SIWIGNYSHV LAFGSRAKST VSAAMELTSP IYAYCGLANF CLGDYEEALA 120
  121 HFLKVETDTS DGIITKTDIS VYISLCALAC W

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 6.522879
Match: 1na0A
Description: Designed protein cTPR3
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [240-422]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DHKRLIQELE RNEEFNALSD LDPSLRRCLQ AKCNRKYSLL LDTLQQNAQD YSLDMYLAPQ  60
   61 LTNLFSLIRE RSLLDYLIPY SALPFSKIAV DFHIDENFIE KNLLEIIEAK KLNGKVDSLQ 120
  121 KRVYIEPSSE PENFEDIKNI AQTSLLYSKA LYLQTLAAMN TENTDDEAPV IAQTNITAED 180
  181 SQN

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 11.69897
Match: 1ufmA
Description: Solution structure of the PCI domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 5.29569167054278 bayes_pls_golite062009
DNA binding 4.90756541371868 bayes_pls_golite062009
nucleic acid binding 4.69183445184264 bayes_pls_golite062009
transcription factor activity 4.14166958134441 bayes_pls_golite062009
binding 3.52874320222492 bayes_pls_golite062009
sequence-specific DNA binding 2.48053910222825 bayes_pls_golite062009
hydrolase activity 2.30467124306022 bayes_pls_golite062009
transcription activator activity 2.29614125067822 bayes_pls_golite062009
transcription repressor activity 2.19033875364989 bayes_pls_golite062009
RNA polymerase II transcription factor activity 1.48055533524841 bayes_pls_golite062009
structure-specific DNA binding 1.33374581364046 bayes_pls_golite062009
small conjugating protein ligase activity 1.27763700765562 bayes_pls_golite062009
ubiquitin-protein ligase activity 1.12147035668008 bayes_pls_golite062009
transcription factor binding 0.83705247708153 bayes_pls_golite062009
acid-amino acid ligase activity 0.754042916649094 bayes_pls_golite062009
protein binding 0.753698599635855 bayes_pls_golite062009
ligase activity, forming carbon-nitrogen bonds 0.486434906547244 bayes_pls_golite062009
double-stranded DNA binding 0.286130392009263 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 0.249771970501337 bayes_pls_golite062009
transferase activity 0.064832527337659 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle