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View Structure Prediction Details

Protein: Cap-PA
Organism: Drosophila melanogaster
Length: 1200 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for Cap-PA.

Description E-value Query
Range		 Subject
Range
gi|68388302 - gi|68388302|ref|XP_696268.1| PREDICTED: similar to slow myosin heavy chain 1 [Danio rerio]
 339.0 [0..60] [1152..1839]

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Predicted Domain #1
Region A:
Residues: [1-87] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MHIKQIIIQG FKSYKDQTVV EPFDKRHNVV VGRNGSGKSN FFYAIQFVLS DEFTHLRPEQ  60
   61 RQSLLHEGTG ARVISAYVEI IFDNSDN

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 39.522879
Match: 1xewX
Description: Structural biochemistry of ATP-driven dimerization and DNA stimulated activation of SMC ATPases.
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [88-417] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RVPIDKEEIF LRRVIGAKKD QYFLNKKVVP RNEVVNLLES AGFSSSNPYY IVKQGKINQM  60
   61 ATAADSYRLK LLREVAGTRV YDERKEESLN LLRETDSKVE KISEYLKTIE DRLQTLEEEK 120
  121 EELKEYQKWD KTRRTLEYIR YETELKDTKK ALDELQLQRK SSSDKKKIYN IEIQKAQEKI 180
  181 KDVQKNLKEA KKKVQSTKEE RSVLMTEQQQ LLREKTKLDL TIVDLNDEVQ GDNKSKERAD 240
  241 QELKNLKVTI AEREKELDDV KPKYEAMKRK EEDCSRELQL KEQKRKELYA KQGRGSQFSS 300
  301 REDRDKWITN ELKSISKQTR DKIAHHAKLV

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 11.154902
Match: 1i84S
Description: Heavy meromyosin subfragment
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [418-454] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EDLKKDATSE KDLGQKIEEH SSELEQLRLQ IDEHNKK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 4.39794
Match: 2i1jA
Description: No description for 2i1jA was found.

Predicted Domain #4
Region A:
Residues: [455-690] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 YYELKKTKDQ HQSMRNELWR KETQMTQQLQ THKEELSRAD QALRSMAGKP ILNGCDSVRK  60
   61 VLDSFVERGG QSAEIARAYY GPVIENFSCD KTIYTAVEVT AANRLFHHIV ESEYEGTQIL 120
  121 KEMNKLKLPG EVTFMPLNRL QVKIHDYPDD PDSIPMISKL KYDEQHDKAL RYIFGKTLIC 180
  181 RNLERATELA KSTGLDCVTL DGDQVSSKGS LTGGYFNTSR SRLEMQKKRT EYTSQI

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 4.69
Match: 1gxlA
Description: Smc hinge domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 2.91859588671053 bayes_pls_golite062009
protein heterodimerization activity 1.04211475755928 bayes_pls_golite062009
protein binding 1.02696508439754 bayes_pls_golite062009
nucleic acid binding 0.832846345187777 bayes_pls_golite062009
structure-specific DNA binding 0.76561882762468 bayes_pls_golite062009
protein dimerization activity 0.734314999998814 bayes_pls_golite062009
DNA binding 0.693468729072494 bayes_pls_golite062009
double-stranded DNA binding 0.489361130553895 bayes_pls_golite062009
DNA secondary structure binding 0.370893450957454 bayes_pls_golite062009
nucleoside-triphosphatase activity 0.299763949828861 bayes_pls_golite062009
catalytic activity 0.265320175609019 bayes_pls_golite062009
pyrophosphatase activity 0.248383422632029 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides 0.235472660839816 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 0.233111707634177 bayes_pls_golite062009
ATP binding 0.161090462621035 bayes_pls_golite062009
adenyl ribonucleotide binding 0.132019153736693 bayes_pls_golite062009
adenyl nucleotide binding 0.123699115804833 bayes_pls_golite062009
ATPase activity 0.08869715759545 bayes_pls_golite062009
sequence-specific DNA binding 0.00495036379814584 bayes_pls_golite062009

Predicted Domain #5
Region A:
Residues: [691-1021] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 AEFEKKLSKL RNELKSTENN INSIVSEMQK TETKQGKSKD VFEKVQGEIR LMKEELVRIE  60
   61 QYRAPKERSL AQCKASLESM TSTKSSLEAE LKQELMSTLS SQDQREIDQL NDDIRRLNQE 120
  121 NKEAFTQRMQ FEVRKNKLDN LLINNLFRRR DELIQALQEI SVEDRKRKLN NCKTELVSAE 180
  181 KRIKKVNSDL EEIEKRVMEA VQLQKELQQE LETHVRKEKE AEENLNKDSK QLEKWSTKEN 240
  241 MLNEKIDECT EKIASLGAVP LVDPSYTRMS LKNIFKELEK ANQHLKKYNH VNKKALDQFL 300
  301 SFSEQKEKLY RRKEELDIGD QKIHMLIQSL E

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 2.42
Match: 1c1gA
Description: Tropomyosin
Matching Structure (courtesy of the PDB):

Predicted Domain #6
Region A:
Residues: [1022-1200] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MQKVEAIQFT FRQVAQNFTK VFKKLVPMGA GFLILKTKDN EGDEMEKEVE NSDAFTGIGI  60
   61 RVSFTGVEAE MREMNQLSGG QKSLVALALI FSIQKCDPAP FYLFDEIDQA LDAMHRKAVA 120
  121 NMIHELSDTA QFITTTFRPE LLENAHKFYG VRFRNKVSHI DCVTREEAKD FVEDDSTHA

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 16.69897
Match: 1xewY
Description: Structural biochemistry of ATP-driven dimerization and DNA stimulated activation of SMC ATPases.
Matching Structure (courtesy of the PDB):
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle