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View Structure Prediction Details

Protein: Cyp4g15-PA, FBpp...
Organism: Drosophila melanogaster
Length: 574 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for Cyp4g15-PA, FBpp....

Description E-value Query
Range
Subject
Range
gi|8570639 - gi|8570639|gb|AAF76522.1| cytochrome P450-4g15 [Drosophila melanogaster]
350.0 [0..1] [574..1]

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Predicted Domain #1
Region A:
Residues: [1-574]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEVLKKDAAL GSPSSVFYFL LLPTLVLWYI YWRLSRAHLY RLAGRLPGPR GLPIVGHLFD  60
   61 VIGPASSVFR TVIRKSAPFE HIAKMWIGPK LVVFIYDPRD VELLLSSHVY IDKASEYKFF 120
  121 KPWLGDGLLI STGQKWRSHR KLIAPTFHLN VLKSFIELFN ENSRNVVRKL RAEDGRTFDC 180
  181 HDYMSEATVE ILLETAMGVS KKTQDKSGFE YAMAVMRMCD ILHARHRSIF LRNEFVFTLT 240
  241 RYYKEQGRLL NIIHGLTTKV IRSKKAAFEQ GTRGSLAQCE LKAAALERER EQNGGVDQTP 300
  301 STAGSDEKDR EKDKEKASPV AGLSYGQSAG LKDDLDVEDN DIGEKKRLAF LDLMLESAQN 360
  361 GALITDTEIK EQVDTIMFEG HDTTAAGSSF FLSLMGIHQD IQDRVLAELD SIFGDSQRPA 420
  421 TFQDTLEMKY LERCLMETLR MYPPVPLIAR ELQEDLKLNS GNYVIPRGAT VTVATVLLHR 480
  481 NPKVYANPNV FDPDNFLPER QANRHYYAFV PFSAGPRSCV GRKYAMLKLK ILLSTILRNY 540
  541 RVYSDLTESD FKLQADIILK REEGFRVRLQ PRTS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 77.09691
Match: 1tqnA
Description: Crystal Structure of Human Microsomal P450 3A4
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
arachidonic acid monooxygenase activity 6.76823710927794 bayes_pls_golite062009
fatty acid (omega-1)-hydroxylase activity 6.3313834755701 bayes_pls_golite062009
monooxygenase activity 5.57229509004705 bayes_pls_golite062009
steroid hydroxylase activity 5.04794778387361 bayes_pls_golite062009
arachidonic acid epoxygenase activity 4.80764258881036 bayes_pls_golite062009
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen 3.24344797738248 bayes_pls_golite062009
demethylase activity 2.80780658333504 bayes_pls_golite062009
oxygen binding 2.77495508953933 bayes_pls_golite062009
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen 2.56821164444595 bayes_pls_golite062009
oxysterol 7-alpha-hydroxylase activity 2.36480328243514 bayes_pls_golite062009
oxidoreductase activity 2.35847923992364 bayes_pls_golite062009
sterol 14-demethylase activity 2.33937429425924 bayes_pls_golite062009
arachidonic acid 11,12-epoxygenase activity 2.0071742914584 bayes_pls_golite062009
retinoid binding 1.84712870343774 bayes_pls_golite062009
isoprenoid binding 1.72341042419615 bayes_pls_golite062009
electron carrier activity 1.48516712188486 bayes_pls_golite062009
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen 1.46109575978397 bayes_pls_golite062009
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen 1.20113920678403 bayes_pls_golite062009
binding 1.0881336564542 bayes_pls_golite062009
steroid 17-alpha-monooxygenase activity 0.88385909514903 bayes_pls_golite062009
catalytic activity 0.608111453189583 bayes_pls_golite062009
testosterone 6-beta-hydroxylase activity 0.38659560844654 bayes_pls_golite062009
cholesterol monooxygenase (side-chain-cleaving) activity 0.276594551871869 bayes_pls_golite062009

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