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View Structure Prediction Details

Protein: Imp-PF, Imp-PE, ...
Organism: Drosophila melanogaster
Length: 573 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for Imp-PF, Imp-PE, ....

Description E-value Query
Range
Subject
Range
gi|25012807 - gi|25012807|gb|AAN71494.1| RE72930p [Drosophila melanogaster]
325.0 [0..1] [542..1]

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Predicted Domain #1
Region A:
Residues: [1-236]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MASELDQFAD LELSKEDREQ IFDPPLDRQQ LEGAGTSRAA VGLNGVEFEG SKLHAEQLDK  60
   61 NQRRSQRNQR NPYPGMPGPG RQADFPLRIL VQSEMVGAII GRQGSTIRTI TQQSRARVDV 120
  121 HRKENVGSLE KSITIYGNPE NCTNACKRIL EVMQQEAIST NKGEICLKIL AHNNLIGRII 180
  181 GKSGNTIKRI MQDTDTKITV SSINDINSFN LERIITVKGL IENMSRAENQ ISTKLR

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 33.69897
Match: 1e3hA
Description: Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3; Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domains 1 and 4; Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 6; Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domains 2 and 5
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 3.24341202600661 bayes_pls_golite062009
RNA binding 2.47373172667773 bayes_pls_golite062009
nucleic acid binding 1.64421905267791 bayes_pls_golite062009
binding 1.38311294671926 bayes_pls_golite062009
structure-specific DNA binding 1.28199205469179 bayes_pls_golite062009
transcription termination factor activity 1.01993495617192 bayes_pls_golite062009
DNA binding 1.01454217691792 bayes_pls_golite062009
single-stranded DNA binding 0.97496043954059 bayes_pls_golite062009
ribonuclease activity 0.702449673647117 bayes_pls_golite062009
structural constituent of ribosome 0.487005194393476 bayes_pls_golite062009
3'-5'-exoribonuclease activity 0.417864080058801 bayes_pls_golite062009
mRNA binding 0.403794675006504 bayes_pls_golite062009
0.371217633915521 bayes_pls_golite062009
sequence-specific DNA binding 0.32084431704638 bayes_pls_golite062009
transcription factor activity 0.298729064067577 bayes_pls_golite062009
structural molecule activity 0.210607270192918 bayes_pls_golite062009
catalytic activity 0.10089766806364 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [237-298]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QSYENDLQAM APQSLMFPGL HPMAMMSTPG NGMVFNTSMP FPSCQSFAMS KTPASVVPPV  60
   61 FP

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [299-469]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NDLQETTYLY IPNNAVGAII GTRGSHIRSI MRFSNASLKI APLDADKPLD QQTERKVTIV  60
   61 GTPEGQWKAQ YMIFEKMREE GFMCGTDDVR LTVELLVASS QVGRIIGKGG QNVRELQRVT 120
  121 GSVIKLPEHA LAPPSGGDEE TPVHIIGLFY SVQSAQRRIR AMMLSTNPPP I

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 19.522879
Match: 1j4wA
Description: Far upstream binding element, FBP, KH3 and KH4 domains
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
RNA binding 5.18414740305744 bayes_pls_golite062009
nucleic acid binding 3.87735820318945 bayes_pls_golite062009
mRNA binding 3.82977088614136 bayes_pls_golite062009
binding 2.8667878224392 bayes_pls_golite062009
transcription regulator activity 1.43703138180882 bayes_pls_golite062009
DNA binding 1.20852534725468 bayes_pls_golite062009
mRNA 3'-UTR binding 0.489176583045793 bayes_pls_golite062009
protein binding 0.468975312217329 bayes_pls_golite062009
0.434422752178353 bayes_pls_golite062009
transcription factor activity 0.386248501195543 bayes_pls_golite062009
catalytic activity 0.113112541746059 bayes_pls_golite062009

Predicted Domain #4
Region A:
Residues: [470-573]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TKKQKAAKEQ LQQQQQSLAG AASSGSQQQQ PQSPSQQQAL PPQLHHQPVS SASSSSTPPA  60
   61 HHQQQASTAA TSHQLQQQQP SPPPPGNATA AAAQQQQQLA SSQQ

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


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