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View Structure Prediction Details

Protein: Imp-PF, Imp-PE, ...
Organism: Drosophila melanogaster
Length: 573 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for Imp-PF, Imp-PE, ....

Description E-value Query
Range		 Subject
Range
gi|25012807 - gi|25012807|gb|AAN71494.1| RE72930p [Drosophila melanogaster]
 325.0 [0..1] [542..1]

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Predicted Domain #1
Region A:
Residues: [1-236] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MASELDQFAD LELSKEDREQ IFDPPLDRQQ LEGAGTSRAA VGLNGVEFEG SKLHAEQLDK  60
   61 NQRRSQRNQR NPYPGMPGPG RQADFPLRIL VQSEMVGAII GRQGSTIRTI TQQSRARVDV 120
  121 HRKENVGSLE KSITIYGNPE NCTNACKRIL EVMQQEAIST NKGEICLKIL AHNNLIGRII 180
  181 GKSGNTIKRI MQDTDTKITV SSINDINSFN LERIITVKGL IENMSRAENQ ISTKLR

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 33.69897
Match: 1e3hA
Description: Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3; Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domains 1 and 4; Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 6; Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domains 2 and 5
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 3.24341202600661 bayes_pls_golite062009
RNA binding 2.47373172667773 bayes_pls_golite062009
nucleic acid binding 1.64421905267791 bayes_pls_golite062009
binding 1.38311294671926 bayes_pls_golite062009
structure-specific DNA binding 1.28199205469179 bayes_pls_golite062009
transcription termination factor activity 1.01993495617192 bayes_pls_golite062009
DNA binding 1.01454217691792 bayes_pls_golite062009
single-stranded DNA binding 0.97496043954059 bayes_pls_golite062009
ribonuclease activity 0.702449673647117 bayes_pls_golite062009
structural constituent of ribosome 0.487005194393476 bayes_pls_golite062009
3'-5'-exoribonuclease activity 0.417864080058801 bayes_pls_golite062009
mRNA binding 0.403794675006504 bayes_pls_golite062009
0.371217633915521 bayes_pls_golite062009
sequence-specific DNA binding 0.32084431704638 bayes_pls_golite062009
transcription factor activity 0.298729064067577 bayes_pls_golite062009
structural molecule activity 0.210607270192918 bayes_pls_golite062009
catalytic activity 0.10089766806364 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [237-298] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QSYENDLQAM APQSLMFPGL HPMAMMSTPG NGMVFNTSMP FPSCQSFAMS KTPASVVPPV  60
   61 FP

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [299-469] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NDLQETTYLY IPNNAVGAII GTRGSHIRSI MRFSNASLKI APLDADKPLD QQTERKVTIV  60
   61 GTPEGQWKAQ YMIFEKMREE GFMCGTDDVR LTVELLVASS QVGRIIGKGG QNVRELQRVT 120
  121 GSVIKLPEHA LAPPSGGDEE TPVHIIGLFY SVQSAQRRIR AMMLSTNPPP I

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 19.522879
Match: 1j4wA
Description: Far upstream binding element, FBP, KH3 and KH4 domains
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
RNA binding 5.18414740305744 bayes_pls_golite062009
nucleic acid binding 3.87735820318945 bayes_pls_golite062009
mRNA binding 3.82977088614136 bayes_pls_golite062009
binding 2.8667878224392 bayes_pls_golite062009
transcription regulator activity 1.43703138180882 bayes_pls_golite062009
DNA binding 1.20852534725468 bayes_pls_golite062009
mRNA 3'-UTR binding 0.489176583045793 bayes_pls_golite062009
protein binding 0.468975312217329 bayes_pls_golite062009
0.434422752178353 bayes_pls_golite062009
transcription factor activity 0.386248501195543 bayes_pls_golite062009
catalytic activity 0.113112541746059 bayes_pls_golite062009

Predicted Domain #4
Region A:
Residues: [470-573] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TKKQKAAKEQ LQQQQQSLAG AASSGSQQQQ PQSPSQQQAL PPQLHHQPVS SASSSSTPPA  60
   61 HHQQQASTAA TSHQLQQQQP SPPPPGNATA AAAQQQQQLA SSQQ

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

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Created and Maintained by: Michael Riffle