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View Structure Prediction Details

Protein: Traf6-PA
Organism: Drosophila melanogaster
Length: 475 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for Traf6-PA.

Description E-value Query
Range
Subject
Range
gi|5714383 - gi|5714383|gb|AAD47895.1|AF079838_1 TRAF6 [Drosophila melanogaster]
224.0 [0..1] [475..1]

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Predicted Domain #1
Region A:
Residues: [1-80]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MQRVQADQKP ARMHQHAHTH SHAHSLQHAE EKEHNSNEMT TNLSSTGRIA ASSSATPSAA  60
   61 AGGGASGAPT PPKSLALNQN 

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [81-196]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 HHYAPGSDTS GEQEEELLDS RYECAICIDW LNEPVLTSCG HRFCRSCLTA WMQKNNQCCP  60
   61 MDNKRLSAEH DIFPDNYTRR EIEQLKRDCP NSSLGCSVVA SPIELHRHLP SCPYRR

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 9.0
Match: 1rmdA
Description: RAG1 DIMERIZATION DOMAIN
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
ubiquitin-protein ligase activity 5.32809533104435 bayes_pls_golite062009
small conjugating protein ligase activity 5.17943669371679 bayes_pls_golite062009
acid-amino acid ligase activity 4.2482314105959 bayes_pls_golite062009
ligase activity, forming carbon-nitrogen bonds 3.07217714843839 bayes_pls_golite062009
protein binding 2.64803540957326 bayes_pls_golite062009
binding 2.14721962003828 bayes_pls_golite062009
transcription regulator activity 1.68475305605912 bayes_pls_golite062009
nucleic acid binding 1.453159800244 bayes_pls_golite062009
ubiquitin-ubiquitin ligase activity 1.37401357060257 bayes_pls_golite062009
chromatin binding 1.30140469366308 bayes_pls_golite062009
DNA binding 1.04821660471647 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 0.73552256979331 bayes_pls_golite062009
small conjugating protein-specific protease activity 0.637551805535732 bayes_pls_golite062009
ligase activity 0.63517530468004 bayes_pls_golite062009
ubiquitin-specific protease activity 0.549461161056205 bayes_pls_golite062009
transcription activator activity 0.546784009980947 bayes_pls_golite062009
transcription factor activity 0.256724934540426 bayes_pls_golite062009
transcription factor binding 0.25479994691323 bayes_pls_golite062009
cysteine-type peptidase activity 0.159023519781458 bayes_pls_golite062009
catalytic activity 0.14112008370434 bayes_pls_golite062009
enzyme binding 0.104373352314595 bayes_pls_golite062009
structure-specific DNA binding 0.0911606411674865 bayes_pls_golite062009
sequence-specific DNA binding 0.017536022609566 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [197-288]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QQEPQEEKCP FAKIKCDFVG RPETNQLEEH LKADMPHHMQ LMLQAFQQTA IATWQPHKPS  60
   61 TSGAAVENGH GQQQLPPPPQ YANGVDEQIV QT

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [289-475]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MYQRIVVLEQ RTREQETRLE NMQKQLRLAR QQAPVDPRYS NGTIVWRIEQ LGALVARLRA  60
   61 NANNQVYSHE CYTSPHGYKF CARLNIQPRK PHVLSLHVHL MQSENDYHLD WPFKGRIKLC 120
  121 MVHPADATLS QHDTIMTKPE ILAFHKPREA ISTRGFGFLE YANISNIIQL GFCADDRLLI 180
  181 KIEINIV

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 36.39794
Match: 1kzzA
Description: TNF receptor associated factor 3 (TRAF3); TRAF3
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle