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View Structure Prediction Details

Protein: danr-PA
Organism: Drosophila melanogaster
Length: 419 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for danr-PA.

Description E-value Query
Range
Subject
Range
DANR_DROPS - Protein distal antenna-related OS=Drosophila pseudoobscura pseudoobscura GN=danr PE=3 SV=1
gi|54640419, gi|... - gi|54640419|gb|EAL29349.1| GA12437-PA [Drosophila pseudoobscura], gi|126002556|ref|XP_001352380.1| G...
218.0 [0..1] [417..1]

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Predicted Domain #1
Region A:
Residues: [1-141]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDISAYQHMN IRMSTRGKRP LRNLTPNDKV RAIQRIHNGE TKASVSRDIG VPESTLRGWC  60
   61 KNEQKLRFMC RQLGPDHLGL DTPPEKRAKF ELQLQLPPKF VALPPNYEEL GFGALPYSPA 120
  121 DYPVQNESLL EKLSLVEFVK K

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 28.522879
Match: 1hlvA
Description: DNA-binding domain of centromere binding protein B (CENP-B)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 5.13863038737912 bayes_pls_golite062009
DNA binding 4.66369707598026 bayes_pls_golite062009
nucleic acid binding 4.20953772435302 bayes_pls_golite062009
transcription factor activity 4.06706589695599 bayes_pls_golite062009
binding 3.02779747447702 bayes_pls_golite062009
sequence-specific DNA binding 2.41271657675151 bayes_pls_golite062009
RNA polymerase II transcription factor activity 2.26183812259792 bayes_pls_golite062009
transcription repressor activity 1.91962622287073 bayes_pls_golite062009
transcription activator activity 1.77700860354597 bayes_pls_golite062009
transcription factor binding 1.40653841901929 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 1.14886080629275 bayes_pls_golite062009
chromatin binding 0.876241359231159 bayes_pls_golite062009
transcription cofactor activity 0.84983974758882 bayes_pls_golite062009
protein binding 0.830419844171551 bayes_pls_golite062009
transcription corepressor activity 0.25931464844298 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [142-263]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NGGLHPEGAL HPGQAGVMDY SNNMLHQLNL LALLNSKLTP QTADVLVDAQ PKSEDNKVID  60
   61 SPAASEDYSK NNYPLLSVKN WAKDPAKRVN SANQPEQVND KNNNALEANS SAPQALVTEQ 120
  121 AK

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [264-419]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TPMFSDTTMP LLPAPFPNPA DLAPVIAPVT PANAPPTGTD NQGAALLDWC KLFNASLNFL  60
   61 AFAAAAASMQ PGGGGPGGPS YNPNQMASGG SEPDLETYPF NEALLKRLSP LAHSEASNES 120
  121 YCDSEPEDLS VRSCASKASS RSHTPDKSVG SSDAEQ

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


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Created and Maintained by: Michael Riffle