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View Structure Prediction Details

Protein: gi|24649179, gi|...
Organism: Drosophila melanogaster
Length: 692 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|24649179, gi|....

Description E-value Query
Range
Subject
Range
gi|73970462 - gi|73970462|ref|XP_531880.2| PREDICTED: similar to Zinc finger protein 208 [Canis familiaris]
620.0 [0..166] [692..404]

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Predicted Domain #1
Region A:
Residues: [1-88]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSSLKTSQS GGMYVKTSSI SGISSISGKE AASCYGGFMS PPLSANITAN NGEREMFRVP  60
   61 GAKVETNESY ACGELQFPDF SHLCFAAE

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [89-293]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TPNSVFSDCH NYAGQDQQQD SDQDDIVCAA AENTGMPYQQ GQYTQLNRED IFRFEPEDIA  60
   61 RLTGESELPG IAQNSQYAVQ PANDSINLDI DYFNYDEINC QSKNQSPCSS PHLDAWLNFN 120
  121 LGEISAAASS SAASPKLGNV FEEQVKEEAS PAKLPSMNST FGTPKCIPMC ASNYEDYANL 180
  181 YQQGSGYSTE NYHNNMAQVV EKPNR

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [294-515]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EHKAIWTIDE LDELMLGEQQ QFLQHHLQQQ HLQEQQEQLH QPHGQEQQTQ NCKDDLVNYL  60
   61 SDEFIKAEEF RSLDSDDDEN YNEEEDDLDN DVFAPPAESD PKPDSTCCDP EAEPENEVIP 120
  121 LICRWTGCDE EFPHQQAFVE HIEKCHVDVR KGEDFSCFWL DCPRRYKPFN ARYKLLIHMR 180
  181 VHSGEKPNKC PFPGCNKAFS RLENLKIHQR SHTGERPYGC QY

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 50.522879
Match: 2i13A
Description: No description for 2i13A was found.

Predicted Domain #4
Region A:
Residues: [516-569]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KGCLKAFSNS SDRAKHQRTH YDTKPYACQL PGCTKRYTDP SSLRKHVKNH ALRN

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 25.69897
Match: 2gliA
Description: Five-finger GLI1
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 4.70988788192472 bayes_pls_golite062009
nucleic acid binding 4.58713908116892 bayes_pls_golite062009
DNA binding 4.56219307357342 bayes_pls_golite062009
transcription factor activity 3.50954949535763 bayes_pls_golite062009
binding 3.10743787485868 bayes_pls_golite062009
RNA polymerase II transcription factor activity 2.31369346002275 bayes_pls_golite062009
transcription activator activity 2.19952417915035 bayes_pls_golite062009
transcription repressor activity 1.64349785387632 bayes_pls_golite062009
chromatin binding 1.53640935908107 bayes_pls_golite062009
sequence-specific DNA binding 1.42975942698743 bayes_pls_golite062009
transcription factor binding 1.39608963544799 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 1.0497955246512 bayes_pls_golite062009
protein binding 1.00484935878505 bayes_pls_golite062009
transcription cofactor activity 0.77874411480713 bayes_pls_golite062009
catalytic activity 0.245893663605433 bayes_pls_golite062009
transcription corepressor activity 0.10558148421807 bayes_pls_golite062009

Predicted Domain #5
Region A:
Residues: [570-692]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ANGQLRRKSA GGASVPPSGP KKAAKTRRHS ESALVQRGVG AGVGVAVPSA PGDQRQHRSN  60
   61 SCSEALLLQQ HQQQQQQQQQ QQKQHQPENV LQDLQHWQPQ QQQQRQQQHM AMATWRPHRK 120
  121 RKC

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 21.30103
Match: 1meyC
Description: Designed zinc finger protein
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle