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View Structure Prediction Details

Protein: gi|24649179, gi|...
Organism: Drosophila melanogaster
Length: 692 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|24649179, gi|....

Description E-value Query
Range
Subject
Range
gi|73970462 - gi|73970462|ref|XP_531880.2| PREDICTED: similar to Zinc finger protein 208 [Canis familiaris]
620.0 [0..166] [692..404]

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Predicted Domain #1
Region A:
Residues: [1-88]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSSLKTSQS GGMYVKTSSI SGISSISGKE AASCYGGFMS PPLSANITAN NGEREMFRVP  60
   61 GAKVETNESY ACGELQFPDF SHLCFAAE

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [89-293]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TPNSVFSDCH NYAGQDQQQD SDQDDIVCAA AENTGMPYQQ GQYTQLNRED IFRFEPEDIA  60
   61 RLTGESELPG IAQNSQYAVQ PANDSINLDI DYFNYDEINC QSKNQSPCSS PHLDAWLNFN 120
  121 LGEISAAASS SAASPKLGNV FEEQVKEEAS PAKLPSMNST FGTPKCIPMC ASNYEDYANL 180
  181 YQQGSGYSTE NYHNNMAQVV EKPNR

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [294-515]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EHKAIWTIDE LDELMLGEQQ QFLQHHLQQQ HLQEQQEQLH QPHGQEQQTQ NCKDDLVNYL  60
   61 SDEFIKAEEF RSLDSDDDEN YNEEEDDLDN DVFAPPAESD PKPDSTCCDP EAEPENEVIP 120
  121 LICRWTGCDE EFPHQQAFVE HIEKCHVDVR KGEDFSCFWL DCPRRYKPFN ARYKLLIHMR 180
  181 VHSGEKPNKC PFPGCNKAFS RLENLKIHQR SHTGERPYGC QY

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 50.522879
Match: 2i13A
Description: No description for 2i13A was found.

Predicted Domain #4
Region A:
Residues: [516-569]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KGCLKAFSNS SDRAKHQRTH YDTKPYACQL PGCTKRYTDP SSLRKHVKNH ALRN

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 25.69897
Match: 2gliA
Description: Five-finger GLI1
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 4.70988788192472 bayes_pls_golite062009
nucleic acid binding 4.58713908116892 bayes_pls_golite062009
DNA binding 4.56219307357342 bayes_pls_golite062009
transcription factor activity 3.50954949535763 bayes_pls_golite062009
binding 3.10743787485868 bayes_pls_golite062009
RNA polymerase II transcription factor activity 2.31369346002275 bayes_pls_golite062009
transcription activator activity 2.19952417915035 bayes_pls_golite062009
transcription repressor activity 1.64349785387632 bayes_pls_golite062009
chromatin binding 1.53640935908107 bayes_pls_golite062009
sequence-specific DNA binding 1.42975942698743 bayes_pls_golite062009
transcription factor binding 1.39608963544799 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 1.0497955246512 bayes_pls_golite062009
protein binding 1.00484935878505 bayes_pls_golite062009
transcription cofactor activity 0.77874411480713 bayes_pls_golite062009
catalytic activity 0.245893663605433 bayes_pls_golite062009
transcription corepressor activity 0.10558148421807 bayes_pls_golite062009

Predicted Domain #5
Region A:
Residues: [570-692]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ANGQLRRKSA GGASVPPSGP KKAAKTRRHS ESALVQRGVG AGVGVAVPSA PGDQRQHRSN  60
   61 SCSEALLLQQ HQQQQQQQQQ QQKQHQPENV LQDLQHWQPQ QQQQRQQQHM AMATWRPHRK 120
  121 RKC

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 21.30103
Match: 1meyC
Description: Designed zinc finger protein
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle