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View Structure Prediction Details

Protein: SNF4Agamma-PK, S...
Organism: Drosophila melanogaster
Length: 906 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SNF4Agamma-PK, S....

Description E-value Query
Range
Subject
Range
gi|27228260, gi|... - gi|27228270|gb|AAN85720.1| loechrig isoform VII [Drosophila melanogaster], gi|27228268|gb|AAN85719.1...
716.0 [0..1] [906..1]

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Predicted Domain #1
Region A:
Residues: [1-215]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MHGITHLYRQ HAVEKQLSGG ESWSRQIYPS YGSSADASSQ GSRLYSVDSS SSSSSNSNNS  60
   61 GGGGSGTAGV ENLGGVTGSA YAQWQSDRHS LPQAVPDAPR SLANHHYRNS PTHQAHYQQP 120
  121 TSGSLKRTPS SKRSFLERSH SPAIYGSMRR SAGPDFGSPP PTAPVGGGGY FPHDLDDIYE 180
  181 SQTDHQYFTH TGASGPQQQR PTAISIFHRV SAAHT

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [216-312]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SLDDYTLPGD ASRQSMNSTD SGVSSGPFNR QRFDNSSFAK SLSIDEQDPQ HSPHKEGHSK  60
   61 HGKHHHHHSH HHHSIHELVK HFGKKMHLWP RKHHDAQ

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [313-412]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SVCTSPQNDP QENFRTRSKS LDVNTLSRPN RILDDCGATY KIYDRIVKEG AHMRRASADL  60
   61 EKRRASVGAA GRGLRGDGTL DPHHAAILFR DSRGLPVADP 

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [413-533]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FLEKVNLSDL EEDDSQIFVK FFRFHKCYDL IPTSAKLVVF DTQLLVKKAF YALVYNGVRA  60
   61 APLWDSEKQQ FVGMLTITDF IKILQMYYKS PNASMEQLEE HKLDTWRSVL HNQVMPLVSI 120
  121 G

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 51.39794
Match: 2v8qE
Description: No description for 2v8qE was found.

Predicted Domain #5
Region A:
Residues: [534-582]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PDASLYDAIK ILIHSRIHRL PVIDPATGNV LYILTHKRIL RFLFLYINE

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 2.65
Match: 1o50A
Description: Crystal structure of CBS domain-containing predicted protein (TM0935) from Thermotoga maritima at 1.87 A resolution
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
phosphorylase kinase regulator activity 7.70391834244316 bayes_pls_golite062009
AMP-activated protein kinase activity 7.44642435115105 bayes_pls_golite062009
cAMP-dependent protein kinase inhibitor activity 6.93689873566354 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 2.56838904228494 bayes_pls_golite062009
protein kinase activity 2.52567871323046 bayes_pls_golite062009
kinase activity 2.4422214009645 bayes_pls_golite062009
cAMP-dependent protein kinase regulator activity 2.35874140792742 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 2.34602478412267 bayes_pls_golite062009
protein serine/threonine kinase activity 2.17402447573866 bayes_pls_golite062009
transferase activity 1.64817967293013 bayes_pls_golite062009
binding 1.63354691422982 bayes_pls_golite062009
protein binding 1.38803085961368 bayes_pls_golite062009
protein kinase binding 1.35253529418057 bayes_pls_golite062009
kinase binding 1.3320291155323 bayes_pls_golite062009
substrate-specific channel activity 1.31002370375073 bayes_pls_golite062009
ion transmembrane transporter activity 1.26281943988481 bayes_pls_golite062009
ion channel activity 0.956667854360503 bayes_pls_golite062009
channel activity 0.940842319076591 bayes_pls_golite062009
passive transmembrane transporter activity 0.940842319076591 bayes_pls_golite062009
metal ion transmembrane transporter activity 0.929686668465826 bayes_pls_golite062009
inorganic cation transmembrane transporter activity 0.889901921302766 bayes_pls_golite062009
gated channel activity 0.736786411102643 bayes_pls_golite062009
cation transmembrane transporter activity 0.709718817747483 bayes_pls_golite062009
enzyme binding 0.263336937308997 bayes_pls_golite062009
protein kinase regulator activity 0.254655971647361 bayes_pls_golite062009
kinase regulator activity 0.22192900867037 bayes_pls_golite062009
catalytic activity 0.205284274859133 bayes_pls_golite062009
PDZ domain binding 0.0288055199494393 bayes_pls_golite062009
di-, tri-valent inorganic cation transmembrane transporter activity 0.00255895098457382 bayes_pls_golite062009

Predicted Domain #6
Region A:
Residues: [583-714]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LPKPAYMQKS LRELKIGTYN NIETADETTS IITALKKFVE RRVSALPLVD SDGRLVDIYA  60
   61 KFDVINLAAE KTYNDLDVSL RKANEHRNEW FEGVQKCNLD ESLYTIMERI VRAEVHRLVV 120
  121 VDENRKVIGI IS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 22.045757
Match: 2uv4A
Description: No description for 2uv4A was found.

Predicted Domain #7
Region A:
Residues: [715-906]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LSDILLYLVL RPSGEGVGGS ESSLRASDPV LLRKVAEVEI PATAAAATTT TPPRSPSAGS  60
   61 GNRSLIEDIP EEETAPARSD DADSDNNKSA SEDKANNNQH DQTTTAATAN GDSNNSPVEV 120
  121 SFADEAQEEE AADQVERSNC DDDDQPALAE IERKNASMDD DEDDGMSSAV SAASALGQSL 180
  181 TPAAQEMALV SE

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 19.522879
Match: 1eepA
Description: Inosine monophosphate dehydrogenase (IMPDH)
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle