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View Structure Prediction Details

Protein: SNF4Agamma-PK, S...
Organism: Drosophila melanogaster
Length: 906 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SNF4Agamma-PK, S....

Description E-value Query
Range
Subject
Range
gi|27228260, gi|... - gi|27228270|gb|AAN85720.1| loechrig isoform VII [Drosophila melanogaster], gi|27228268|gb|AAN85719.1...
716.0 [0..1] [906..1]

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Predicted Domain #1
Region A:
Residues: [1-215]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MHGITHLYRQ HAVEKQLSGG ESWSRQIYPS YGSSADASSQ GSRLYSVDSS SSSSSNSNNS  60
   61 GGGGSGTAGV ENLGGVTGSA YAQWQSDRHS LPQAVPDAPR SLANHHYRNS PTHQAHYQQP 120
  121 TSGSLKRTPS SKRSFLERSH SPAIYGSMRR SAGPDFGSPP PTAPVGGGGY FPHDLDDIYE 180
  181 SQTDHQYFTH TGASGPQQQR PTAISIFHRV SAAHT

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [216-312]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SLDDYTLPGD ASRQSMNSTD SGVSSGPFNR QRFDNSSFAK SLSIDEQDPQ HSPHKEGHSK  60
   61 HGKHHHHHSH HHHSIHELVK HFGKKMHLWP RKHHDAQ

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [313-412]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SVCTSPQNDP QENFRTRSKS LDVNTLSRPN RILDDCGATY KIYDRIVKEG AHMRRASADL  60
   61 EKRRASVGAA GRGLRGDGTL DPHHAAILFR DSRGLPVADP 

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [413-533]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FLEKVNLSDL EEDDSQIFVK FFRFHKCYDL IPTSAKLVVF DTQLLVKKAF YALVYNGVRA  60
   61 APLWDSEKQQ FVGMLTITDF IKILQMYYKS PNASMEQLEE HKLDTWRSVL HNQVMPLVSI 120
  121 G

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 51.39794
Match: 2v8qE
Description: No description for 2v8qE was found.

Predicted Domain #5
Region A:
Residues: [534-582]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PDASLYDAIK ILIHSRIHRL PVIDPATGNV LYILTHKRIL RFLFLYINE

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 2.65
Match: 1o50A
Description: Crystal structure of CBS domain-containing predicted protein (TM0935) from Thermotoga maritima at 1.87 A resolution
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
phosphorylase kinase regulator activity 7.70391834244316 bayes_pls_golite062009
AMP-activated protein kinase activity 7.44642435115105 bayes_pls_golite062009
cAMP-dependent protein kinase inhibitor activity 6.93689873566354 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 2.56838904228494 bayes_pls_golite062009
protein kinase activity 2.52567871323046 bayes_pls_golite062009
kinase activity 2.4422214009645 bayes_pls_golite062009
cAMP-dependent protein kinase regulator activity 2.35874140792742 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 2.34602478412267 bayes_pls_golite062009
protein serine/threonine kinase activity 2.17402447573866 bayes_pls_golite062009
transferase activity 1.64817967293013 bayes_pls_golite062009
binding 1.63354691422982 bayes_pls_golite062009
protein binding 1.38803085961368 bayes_pls_golite062009
protein kinase binding 1.35253529418057 bayes_pls_golite062009
kinase binding 1.3320291155323 bayes_pls_golite062009
substrate-specific channel activity 1.31002370375073 bayes_pls_golite062009
ion transmembrane transporter activity 1.26281943988481 bayes_pls_golite062009
ion channel activity 0.956667854360503 bayes_pls_golite062009
channel activity 0.940842319076591 bayes_pls_golite062009
passive transmembrane transporter activity 0.940842319076591 bayes_pls_golite062009
metal ion transmembrane transporter activity 0.929686668465826 bayes_pls_golite062009
inorganic cation transmembrane transporter activity 0.889901921302766 bayes_pls_golite062009
gated channel activity 0.736786411102643 bayes_pls_golite062009
cation transmembrane transporter activity 0.709718817747483 bayes_pls_golite062009
enzyme binding 0.263336937308997 bayes_pls_golite062009
protein kinase regulator activity 0.254655971647361 bayes_pls_golite062009
kinase regulator activity 0.22192900867037 bayes_pls_golite062009
catalytic activity 0.205284274859133 bayes_pls_golite062009
PDZ domain binding 0.0288055199494393 bayes_pls_golite062009
di-, tri-valent inorganic cation transmembrane transporter activity 0.00255895098457382 bayes_pls_golite062009

Predicted Domain #6
Region A:
Residues: [583-714]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LPKPAYMQKS LRELKIGTYN NIETADETTS IITALKKFVE RRVSALPLVD SDGRLVDIYA  60
   61 KFDVINLAAE KTYNDLDVSL RKANEHRNEW FEGVQKCNLD ESLYTIMERI VRAEVHRLVV 120
  121 VDENRKVIGI IS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 22.045757
Match: 2uv4A
Description: No description for 2uv4A was found.

Predicted Domain #7
Region A:
Residues: [715-906]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LSDILLYLVL RPSGEGVGGS ESSLRASDPV LLRKVAEVEI PATAAAATTT TPPRSPSAGS  60
   61 GNRSLIEDIP EEETAPARSD DADSDNNKSA SEDKANNNQH DQTTTAATAN GDSNNSPVEV 120
  121 SFADEAQEEE AADQVERSNC DDDDQPALAE IERKNASMDD DEDDGMSSAV SAASALGQSL 180
  181 TPAAQEMALV SE

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 19.522879
Match: 1eepA
Description: Inosine monophosphate dehydrogenase (IMPDH)
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle