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View Structure Prediction Details

Protein: SNF4Agamma-PB, S...
Organism: Drosophila melanogaster
Length: 947 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SNF4Agamma-PB, S....

Description E-value Query
Range
Subject
Range
SNF4Agamma-PF, S... - The gene SNF4/AMP-activated protein kinase gamma subunit is referred to in FlyBase by the symbol Dme...
648.0 [0..32] [947..467]

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Predicted Domain #1
Region A:
Residues: [1-281]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MQSSAGGASG GSNYEDVAAA RRGRFRVTSS TPQGPPETTL GRFRLMPTSN YGAISPILQR  60
   61 GRFAVIPEEP QAGSPALGTP PPGGRTARSP SPEWDFDIEQ EQDGSLGGAG RMPGSRPSSA 120
  121 PAEPNAKAAK KAYKKMEKEQ RRQEKEQSRR EKEARKLERE TARRNEREAA KLEKINRHSE 180
  181 KISRSTERMA MAGVGSRSGS LERRRSGEDS PVLNQSTVHG IASPNRRPTI FDVFRPRAKS 240
  241 DAKRQKEKHL LDPSSADSSA TSSTYSVSGG TGPATSSAAG G

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 1.2
Match: 2i1jA
Description: No description for 2i1jA was found.

Predicted Domain #2
Region A:
Residues: [282-451]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 AGGAAAAAGQ GAAGGAGGLM NSMKVAMQNF SHRQHPAVTI TSADGTQSTA KSKYKDGSAH  60
   61 PHQGSDAQYY HTVTAVRPNS SQRSPMTKVM DLFRHRSSSV VSEADKRKAR AAAHQQQLAV 120
  121 QSAHMRRASA DLEKRRASVG AAGRGLRGDG TLDPHHAAIL FRDSRGLPVA 

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [452-518]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DPFLEKVNLS DLEEDDSQIF VKFFRFHKCY DLIPTSAKLV VFDTQLLVKK AFYALVYNGV  60
   61 RAAPLWD

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 54.39794
Match: 2v8qE
Description: No description for 2v8qE was found.

Predicted Domain #4
Region A:
Residues: [519-623]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SEKQQFVGML TITDFIKILQ MYYKSPNASM EQLEEHKLDT WRSVLHNQVM PLVSIGPDAS  60
   61 LYDAIKILIH SRIHRLPVID PATGNVLYIL THKRILRFLF LYINE

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 4.12
Match: 1o50A
Description: Crystal structure of CBS domain-containing predicted protein (TM0935) from Thermotoga maritima at 1.87 A resolution
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
phosphorylase kinase regulator activity 7.70391834244316 bayes_pls_golite062009
AMP-activated protein kinase activity 7.44642435115105 bayes_pls_golite062009
cAMP-dependent protein kinase inhibitor activity 6.93689873566354 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 2.56838904228494 bayes_pls_golite062009
protein kinase activity 2.52567871323046 bayes_pls_golite062009
kinase activity 2.4422214009645 bayes_pls_golite062009
cAMP-dependent protein kinase regulator activity 2.35874140792742 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 2.34602478412267 bayes_pls_golite062009
protein serine/threonine kinase activity 2.17402447573866 bayes_pls_golite062009
transferase activity 1.64817967293013 bayes_pls_golite062009
binding 1.63354691422982 bayes_pls_golite062009
protein binding 1.38803085961368 bayes_pls_golite062009
protein kinase binding 1.35253529418057 bayes_pls_golite062009
kinase binding 1.3320291155323 bayes_pls_golite062009
substrate-specific channel activity 1.31002370375073 bayes_pls_golite062009
ion transmembrane transporter activity 1.26281943988481 bayes_pls_golite062009
ion channel activity 0.956667854360503 bayes_pls_golite062009
channel activity 0.940842319076591 bayes_pls_golite062009
passive transmembrane transporter activity 0.940842319076591 bayes_pls_golite062009
metal ion transmembrane transporter activity 0.929686668465826 bayes_pls_golite062009
inorganic cation transmembrane transporter activity 0.889901921302766 bayes_pls_golite062009
gated channel activity 0.736786411102643 bayes_pls_golite062009
cation transmembrane transporter activity 0.709718817747483 bayes_pls_golite062009
enzyme binding 0.263336937308997 bayes_pls_golite062009
protein kinase regulator activity 0.254655971647361 bayes_pls_golite062009
kinase regulator activity 0.22192900867037 bayes_pls_golite062009
catalytic activity 0.205284274859133 bayes_pls_golite062009
PDZ domain binding 0.0288055199494393 bayes_pls_golite062009
di-, tri-valent inorganic cation transmembrane transporter activity 0.00255895098457382 bayes_pls_golite062009

Predicted Domain #5
Region A:
Residues: [624-693]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LPKPAYMQKS LRELKIGTYN NIETADETTS IITALKKFVE RRVSALPLVD SDGRLVDIYA  60
   61 KFDVINLAAE 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 22.0
Match: 2uv4A
Description: No description for 2uv4A was found.

Predicted Domain #6
Region A:
Residues: [694-947]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KTYNDLDVSL RKANEHRNEW FEGVQKCNLD ESLYTIMERI VRAEVHRLVV VDENRKVIGI  60
   61 ISLSDILLYL VLRPSGEGVG GSESSLRASD PVLLRKVAEV EIPATAAAAT TTTPPRSPSA 120
  121 GSGNRSLIED IPEEETAPAR SDDADSDNNK SASEDKANNN QHDQTTTAAT ANGDSNNSPV 180
  181 EVSFADEAQE EEAADQVERS NCDDDDQPAL AEIERKNASM DDDEDDGMSS AVSAASALGQ 240
  241 SLTPAAQEMA LVSE

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 20.69897
Match: 1ypfA
Description: Crystal Structure of GuaC (BA5705) from Bacillus anthracis at 1.8 A Resolution
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle