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View Structure Prediction Details

Protein: mus308-PA
Organism: Drosophila melanogaster
Length: 2059 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for mus308-PA.

Description E-value Query
Range		 Subject
Range
gi|60678001 - gi|60678001|gb|AAX33507.1| LP14642p [Drosophila melanogaster]
 1393.0 [0..1] [2059..1]

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Predicted Domain #1
Region A:
Residues: [1-138] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAFSQSFNFG NSTLMALEKG MQADDKENAQ PGNGNIQVQS AGNEVNSEIQ EINSEFFRDE  60
   61 FSYEVNQAHK PAEQSVVNVS QVQQHMAVVS NQDSEDQSRS SALNDQICTQ SSFEGEDAGA 120
  121 DAVLDQPNLD ENSFLCPA

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [139-208] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QDEEASEQLK EDILHSHSVL AKQEFYQEIS QVTQNLSSMS PNQLRVSPNS SRIREAMPER  60
   61 PAMPLDLNTL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 71.154902
Match: 2db3A
Description: No description for 2db3A was found.

Predicted Domain #3
Region A:
Residues: [209-1040] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RSISAWNLPM SIQAEYKKKG VVDMFDWQVE CLSKPRLLFE HCNLVYSAPT SAGKTLVSEI  60
   61 LMLKTVLERG KKVLLILPFI SVVREKMFYM QDLLTPAGYR VEGFYGGYTP PGGFESLHVA 120
  121 ICTIEKANSI VNKLMEQGKL ETIGMVVVDE VHLISDKGRG YILELLLAKI LYMSRRNGLQ 180
  181 IQVITMSATL ENVQLLQSWL DAELYITNYR PVALKEMIKV GTVIYDHRLK LVRDVAKQKV 240
  241 LLKGLENDSD DVALLCIETL LEGCSVIVFC PSKDWCENLA VQLATAIHVQ IKSETVLGQR 300
  301 LRTNLNPRAI AEVKQQLRDI PTGLDGVMSK AITYACAFHH AGLTTEERDI IEASFKAGAL 360
  361 KVLVATSTLS SGVNLPARRV LIRSPLFGGK QMSSLTYRQM IGRAGRMGKD TLGESILICN 420
  421 EINARMGRDL VVSELQPITS CLDMDGSTHL KRALLEVISS GVANTKEDID FFVNCTLLSA 480
  481 QKAFHAKEKP PDEESDANYI NDALDFLVEY EFVRLQRNEE RETAVYVATR LGAACLASSM 540
  541 PPTDGLILFA ELQKSRRSFV LESELHAVYL VTPYSVCYQL QDIDWLLYVH MWEKLSSPMK 600
  601 KVGELVGVRD AFLYKALRGQ TKLDYKQMQI HKRFYIALAL EELVNETPIN VVVHKYKCHR 660
  661 GMLQSLQQMA STFAGIVTAF CNSLQWSTLA LIVSQFKDRL FFGIHRDLID LMRIPDLSQK 720
  721 RARALFDAGI TSLVELAGAD PVELEKVLYN SISFDSAKQH DHENADEAAK RNVVRNFYIT 780
  781 GKAGMTVSEA AKLLIGEARQ FVQHEIGLGT IKWTQTQAGV EIASRAIHDG GE

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 91.39794
Match: 2p6rA
Description: No description for 2p6rA was found.

Predicted functions:

Term Confidence Notes
catalytic activity 1.37148167194523 bayes_pls_golite062009
hydrolase activity 1.18412998130788 bayes_pls_golite062009
pyrophosphatase activity 1.16998111465319 bayes_pls_golite062009
nucleoside-triphosphatase activity 1.16375481834344 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides 1.15942143195918 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 1.15882580213621 bayes_pls_golite062009
binding 0.712909626033412 bayes_pls_golite062009
ATPase activity 0.62253664120117 bayes_pls_golite062009
helicase activity 0.00674361801283974 bayes_pls_golite062009

Predicted Domain #4
Region A:
Residues: [1041-1132] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VDLHMSLEEE QPPVKRKLSI EENGTANSQK NPRLETVVDT QRGYKVDKNI ANQSKMNPNL  60
   61 KEIDAQNKAR RNSTAHMDNL NPISNDPCQN NV

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #5
Region A:
Residues: [1133-1264] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NVKTAQPIIS NLNDIQKQGS QIEKMKINPA TVVCSPQLAN EEKPSTSQSA RRKLVNEGMA  60
   61 ERRRVALMKI QQRTQKENQS KDQPIQASRS NQLSSPVNRT PANRWTQSEN PNNEMNNSQL 120
  121 PRRNPRNQSP VP

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #6
Region A:
Residues: [1265-1448] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NANRTASRKV SNAEEDLFMA DDSFMLNTGL AAALTAAESK IASCTEADVI PSSQPKEPEV  60
   61 IGALTPHASR LKRSDQLRSQ RIQSPSPTPQ REIEIDLESK NESNGVSSME ISDMSMENPL 120
  121 MKNPLHLNAS HIMSCSKVDE TASSFSSIDI IDVCGHRNAF QAAIIEINNA TRLGFSVGLQ 180
  181 AQAG

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #7
Region A:
Residues: [1449-2059] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KQKPLIGSNL LINQVAAAEN REAAARERVL FQVDDTNFIS GVSFCLADNV AYYWNMQIDE  60
   61 RAAYQGVPTP LKVQELCNLM ARKDLTLVMH DGKEQLKMLR KAIPQLKRIS AKLEDAKVAN 120
  121 WLLQPDKTVN FLNMCQTFAP ECTGLANLCG SGRGYSSYGL DTSSAILPRI RTAIESCVTL 180
  181 HILQGQTENL SRIGNGDLLK FFHDIEMPIQ LTLCQMELVG FPAQKQRLQQ LYQRMVAVMK 240
  241 KVETKIYEQH GSRFNLGSSQ AVAKVLGLHR KAKGRVTTSR QVLEKLNSPI SHLILGYRKL 300
  301 SGLLAKSIQP LMECCQADRI HGQSITYTAT GRISMTEPNL QNVAKEFSIQ VGSDVVHISC 360
  361 RSPFMPTDES RCLLSADFCQ LEMRILAHMS QDKALLEVMK SSQDLFIAIA AHWNKIEESE 420
  421 VTQDLRNSTK QVCYGIVYGM GMRSLAESLN CSEQEARMIS DQFHQAYKGI RDYTTRVVNF 480
  481 ARSKGFVETI TGRRRYLENI NSDVEHLKNQ AERQAVNSTI QGSAADIAKN AILKMEKNIE 540
  541 RYREKLALGD NSVDLVMHLH DELIFEVPTG KAKKIAKVLS LTMENCVKLS VPLKVKLRIG 600
  601 RSWGEFKEVS V

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 1000.0
Match: 1dpiA
Description: STRUCTURE OF LARGE FRAGMENT OF ESCHERICHIA COLI DNA POLYMERASE I COMPLEXED WITH D/TMP
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
nuclease activity 1.81796593394339 bayes_pls_golite062009
exonuclease activity 1.64964907710028 bayes_pls_golite062009
catalytic activity 1.62277843225829 bayes_pls_golite062009
hydrolase activity, acting on ester bonds 1.58702937619673 bayes_pls_golite062009
hydrolase activity 1.41857676124086 bayes_pls_golite062009
ribonuclease activity 0.71352601607444 bayes_pls_golite062009
deoxyribonuclease activity 0.63299586096139 bayes_pls_golite062009
exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 0.62821439153618 bayes_pls_golite062009
endonuclease activity 0.150927275899469 bayes_pls_golite062009
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle