| Protein: | RpA-70-PA |
| Organism: | Drosophila melanogaster |
| Length: | 603 amino acids |
| Reference: | Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16 |
Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for RpA-70-PA.
| Description | E-value | Query Range |
Subject Range |
|
|
563.0 | [0..2] | [595..55] |
|
Region A: Residues: [1-146] |
1 11 21 31 41 51
| | | | | |
1 MVLASLSTGV IARIMHGEVV DAPVLQILAI KKINSAADSE RYRILISDGK YFNSYAMLAS 60
61 QLNVMQHNGE LEEFTIVQLD KYVTSLVGKD GAGKRVLIIS ELTVVNPGAE VKSKIGEPVT 120
121 YENAAKQDLA PKPAVTSNSK PIAKKE
|
| Detection Method: |  |
| Confidence: | 34.522879 |
| Match: | 2b29A |
| Description: | N-terminal domain of the RPA70 subunit of human replication protein A. |
Matching Structure (courtesy of the PDB): |
|
| Term | Confidence | Notes |
| telomeric DNA binding | 7.07761964836826 | bayes_pls_golite062009 |
| single-stranded telomeric DNA binding | 6.04637014849887 | bayes_pls_golite062009 |
| telomerase inhibitor activity | 5.40477712257453 | bayes_pls_golite062009 |
| nucleic acid binding | 4.02967008021862 | bayes_pls_golite062009 |
| DNA binding | 3.62735703519187 | bayes_pls_golite062009 |
| single-stranded DNA binding | 3.59212997362902 | bayes_pls_golite062009 |
| structure-specific DNA binding | 3.53214384646348 | bayes_pls_golite062009 |
| binding | 2.83465364476231 | bayes_pls_golite062009 |
| structural constituent of ribosome | 2.25006883439646 | bayes_pls_golite062009 |
| transcription regulator activity | 2.20239961025491 | bayes_pls_golite062009 |
| structural molecule activity | 2.07809455998137 | bayes_pls_golite062009 |
| protein binding | 1.20309946451799 | bayes_pls_golite062009 |
| ribonuclease activity | 1.19236946227657 | bayes_pls_golite062009 |
| DNA helicase activity | 1.12203697857261 | bayes_pls_golite062009 |
| transcription factor activity | 1.05816813143865 | bayes_pls_golite062009 |
| sequence-specific DNA binding | 0.86170694706755 | bayes_pls_golite062009 |
| DNA-directed RNA polymerase activity | 0.79554655100991 | bayes_pls_golite062009 |
| RNA polymerase activity | 0.79554655100991 | bayes_pls_golite062009 |
| hydrolase activity | 0.724860465280978 | bayes_pls_golite062009 |
| DNA-dependent ATPase activity | 0.638831894247026 | bayes_pls_golite062009 |
| nuclease activity | 0.57381531077345 | bayes_pls_golite062009 |
| DEAD/H-box RNA helicase binding | 0.440977654731901 | bayes_pls_golite062009 |
| translation regulator activity | 0.41164963411369 | bayes_pls_golite062009 |
| double-stranded DNA binding | 0.378383789953688 | bayes_pls_golite062009 |
| translation factor activity, nucleic acid binding | 0.360862776629591 | bayes_pls_golite062009 |
| nucleotidyltransferase activity | 0.325774164899685 | bayes_pls_golite062009 |
| four-way junction helicase activity | 0.31769813397725 | bayes_pls_golite062009 |
| RNA binding | 0.31028563542112 | bayes_pls_golite062009 |
| translation initiation factor activity | 0.30211828233765 | bayes_pls_golite062009 |
| exonuclease activity | 0.28313884527829 | bayes_pls_golite062009 |
| transferase activity, transferring phosphorus-containing groups | 0.226916777208049 | bayes_pls_golite062009 |
| hydrolase activity, acting on ester bonds | 0.223941674251642 | bayes_pls_golite062009 |
| exoribonuclease activity, producing 5'-phosphomonoesters | 0.125256208482441 | bayes_pls_golite062009 |
| exoribonuclease activity | 0.109774918833391 | bayes_pls_golite062009 |
| exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters | 0.0954216620147701 | bayes_pls_golite062009 |
| ATP-dependent DNA helicase activity | 0.0179535526984695 | bayes_pls_golite062009 |
| helicase activity | 0.0121541775159524 | bayes_pls_golite062009 |
|
Region A: Residues: [147-417] |
1 11 21 31 41 51
| | | | | |
1 PSHNNNNNIV MNSSINSGMT HPISSLSPYQ NKWVIKARVT SKSGIRTWSN ARGEGKLFSM 60
61 DLMDESGEIR ATAFKEQCDK FYDLIQVDSV YYISKCQLKP ANKQYSSLNN AYEMTFSGET 120
121 VVQLCEDTDD DPIPEIKYNL VPISDVSGME NKAAVDTIGI CKEVGELQSF VARTTNKEFK 180
181 KRDITLVDMS NSAISLTLWG DDAVNFDGHV QPVILVKGTR INEFNGGKSL SLGGGSIMKI 240
241 NPDIPEAHKL RGWFDNGGGD SVANMVSART G
|
| Detection Method: | |
| Confidence: | 55.69897 |
| Match: | 1jmcA |
| Description: | Replication protein A 70 KDa subunit (RPA70) |
Matching Structure (courtesy of the PDB): |
|
| Term | Confidence | Notes |
| telomeric DNA binding | 7.07761964836826 | bayes_pls_golite062009 |
| single-stranded telomeric DNA binding | 6.04637014849887 | bayes_pls_golite062009 |
| telomerase inhibitor activity | 5.40477712257453 | bayes_pls_golite062009 |
| nucleic acid binding | 4.02967008021862 | bayes_pls_golite062009 |
| DNA binding | 3.62735703519187 | bayes_pls_golite062009 |
| single-stranded DNA binding | 3.59212997362902 | bayes_pls_golite062009 |
| structure-specific DNA binding | 3.53214384646348 | bayes_pls_golite062009 |
| binding | 2.83465364476231 | bayes_pls_golite062009 |
| structural constituent of ribosome | 2.25006883439646 | bayes_pls_golite062009 |
| transcription regulator activity | 2.20239961025491 | bayes_pls_golite062009 |
| structural molecule activity | 2.07809455998137 | bayes_pls_golite062009 |
| protein binding | 1.20309946451799 | bayes_pls_golite062009 |
| ribonuclease activity | 1.19236946227657 | bayes_pls_golite062009 |
| DNA helicase activity | 1.12203697857261 | bayes_pls_golite062009 |
| transcription factor activity | 1.05816813143865 | bayes_pls_golite062009 |
| sequence-specific DNA binding | 0.86170694706755 | bayes_pls_golite062009 |
| DNA-directed RNA polymerase activity | 0.79554655100991 | bayes_pls_golite062009 |
| RNA polymerase activity | 0.79554655100991 | bayes_pls_golite062009 |
| hydrolase activity | 0.724860465280978 | bayes_pls_golite062009 |
| DNA-dependent ATPase activity | 0.638831894247026 | bayes_pls_golite062009 |
| nuclease activity | 0.57381531077345 | bayes_pls_golite062009 |
| DEAD/H-box RNA helicase binding | 0.440977654731901 | bayes_pls_golite062009 |
| translation regulator activity | 0.41164963411369 | bayes_pls_golite062009 |
| double-stranded DNA binding | 0.378383789953688 | bayes_pls_golite062009 |
| translation factor activity, nucleic acid binding | 0.360862776629591 | bayes_pls_golite062009 |
| nucleotidyltransferase activity | 0.325774164899685 | bayes_pls_golite062009 |
| four-way junction helicase activity | 0.31769813397725 | bayes_pls_golite062009 |
| RNA binding | 0.31028563542112 | bayes_pls_golite062009 |
| translation initiation factor activity | 0.30211828233765 | bayes_pls_golite062009 |
| exonuclease activity | 0.28313884527829 | bayes_pls_golite062009 |
| transferase activity, transferring phosphorus-containing groups | 0.226916777208049 | bayes_pls_golite062009 |
| hydrolase activity, acting on ester bonds | 0.223941674251642 | bayes_pls_golite062009 |
| exoribonuclease activity, producing 5'-phosphomonoesters | 0.125256208482441 | bayes_pls_golite062009 |
| exoribonuclease activity | 0.109774918833391 | bayes_pls_golite062009 |
| exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters | 0.0954216620147701 | bayes_pls_golite062009 |
| ATP-dependent DNA helicase activity | 0.0179535526984695 | bayes_pls_golite062009 |
| helicase activity | 0.0121541775159524 | bayes_pls_golite062009 |
|
Region A: Residues: [418-603] |
1 11 21 31 41 51
| | | | | |
1 GGSFSTEWMT LKDARARNLG SGDKPDYFQC KAVVHIVKQE NAFYRACPQS DCNKKVVDEG 60
61 NDQFRCEKCN ALFPNFKYRL LINMSIGDWT SNRWVSSFNE VGEQLLGHTS QEVGEALEND 120
121 PAKAEQIFSA LNFTSHIFKL RCKNEVYGDM TRNKLTVQSV APINHKEYNK HLLKELQELT 180
181 GIGSSN
|
| Detection Method: | |
| Confidence: | 49.522879 |
| Match: | 1l1oC |
| Description: | Replication protein A 70 KDa subunit (RPA70) |
Matching Structure (courtesy of the PDB): |
|
| Term | Confidence | Notes |
| telomeric DNA binding | 7.07761964836826 | bayes_pls_golite062009 |
| single-stranded telomeric DNA binding | 6.04637014849887 | bayes_pls_golite062009 |
| telomerase inhibitor activity | 5.40477712257453 | bayes_pls_golite062009 |
| nucleic acid binding | 4.02967008021862 | bayes_pls_golite062009 |
| DNA binding | 3.62735703519187 | bayes_pls_golite062009 |
| single-stranded DNA binding | 3.59212997362902 | bayes_pls_golite062009 |
| structure-specific DNA binding | 3.53214384646348 | bayes_pls_golite062009 |
| binding | 2.83465364476231 | bayes_pls_golite062009 |
| structural constituent of ribosome | 2.25006883439646 | bayes_pls_golite062009 |
| transcription regulator activity | 2.20239961025491 | bayes_pls_golite062009 |
| structural molecule activity | 2.07809455998137 | bayes_pls_golite062009 |
| protein binding | 1.20309946451799 | bayes_pls_golite062009 |
| ribonuclease activity | 1.19236946227657 | bayes_pls_golite062009 |
| DNA helicase activity | 1.12203697857261 | bayes_pls_golite062009 |
| transcription factor activity | 1.05816813143865 | bayes_pls_golite062009 |
| sequence-specific DNA binding | 0.86170694706755 | bayes_pls_golite062009 |
| DNA-directed RNA polymerase activity | 0.79554655100991 | bayes_pls_golite062009 |
| RNA polymerase activity | 0.79554655100991 | bayes_pls_golite062009 |
| hydrolase activity | 0.724860465280978 | bayes_pls_golite062009 |
| DNA-dependent ATPase activity | 0.638831894247026 | bayes_pls_golite062009 |
| nuclease activity | 0.57381531077345 | bayes_pls_golite062009 |
| DEAD/H-box RNA helicase binding | 0.440977654731901 | bayes_pls_golite062009 |
| translation regulator activity | 0.41164963411369 | bayes_pls_golite062009 |
| double-stranded DNA binding | 0.378383789953688 | bayes_pls_golite062009 |
| translation factor activity, nucleic acid binding | 0.360862776629591 | bayes_pls_golite062009 |
| nucleotidyltransferase activity | 0.325774164899685 | bayes_pls_golite062009 |
| four-way junction helicase activity | 0.31769813397725 | bayes_pls_golite062009 |
| RNA binding | 0.31028563542112 | bayes_pls_golite062009 |
| translation initiation factor activity | 0.30211828233765 | bayes_pls_golite062009 |
| exonuclease activity | 0.28313884527829 | bayes_pls_golite062009 |
| transferase activity, transferring phosphorus-containing groups | 0.226916777208049 | bayes_pls_golite062009 |
| hydrolase activity, acting on ester bonds | 0.223941674251642 | bayes_pls_golite062009 |
| exoribonuclease activity, producing 5'-phosphomonoesters | 0.125256208482441 | bayes_pls_golite062009 |
| exoribonuclease activity | 0.109774918833391 | bayes_pls_golite062009 |
| exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters | 0.0954216620147701 | bayes_pls_golite062009 |
| ATP-dependent DNA helicase activity | 0.0179535526984695 | bayes_pls_golite062009 |
| helicase activity | 0.0121541775159524 | bayes_pls_golite062009 |
