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View Structure Prediction Details

Protein: MTA1-like-PA
Organism: Drosophila melanogaster
Length: 880 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for MTA1-like-PA.

Description E-value Query
Range
Subject
Range
gi|55240723, gi|... - gi|58384988|ref|XP_313620.2| ENSANGP00000012666 [Anopheles gambiae str. PEST], gi|55240723|gb|EAA092...
603.0 [0..1] [874..1]

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Predicted Domain #1
Region A:
Residues: [1-270]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MATNMYRVGD YVYVETTPNS PYLIRRIEEL NKNQTGNVEA KVMCFYRRRD LPNPLVQLAD  60
   61 KHQLATAEDS PLATKLKKTW LRTPVSEEQA AQAVLDPSIA ALDEERTSPT QTSGGGGSAT 120
  121 GNSGSNSSGT SNNNSSSTAI GGGAGGSGGA GGDAEKGEAL TSKQRYQIKH RELFLSRQVE 180
  181 SIPATQIRGK CSVTLLNETE SLQSYLNKDD TFFYCLVFDP NQKTLLADKG EIRVGSRYQC 240
  241 DIPAKLKDTA TDDRKLEELE SLVWTPEHSL 

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 2.0
Match: 1w4sA
Description: Crystal structure of the proximal BAH domain of polybromo
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [271-352]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TDRKIDQFLV VSRSIGTFAR ALDCSSSVKQ PSLHMSAAAA SRDITLFHAM NILHKHEYSI  60
   61 EESMSSLVPS TGPVLCRDEI ED

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [353-418]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 WSASEANLFE EALEKYGKDF NDIRQDFLPW KTLKQIIEYY YMWKTTDRYV QQKRVKAVEA  60
   61 ELKLKQ

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 18.522879
Match: 2crgA
Description: Solution structure of the myb-like DNA-binding domain of mouse MTA3 protein
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 2.87991790206998 bayes_pls_golite062009
transcription regulator activity 2.122580758085 bayes_pls_golite062009
DNA binding 1.98453325263719 bayes_pls_golite062009
nucleic acid binding 1.93681952439958 bayes_pls_golite062009
transcription factor activity 1.36872096268289 bayes_pls_golite062009
protein deacetylase activity 1.30097338817679 bayes_pls_golite062009
histone deacetylase activity 1.21500914041004 bayes_pls_golite062009
RNA polymerase II transcription factor activity 1.09150919349912 bayes_pls_golite062009
sequence-specific DNA binding 1.03881604759993 bayes_pls_golite062009
protein binding 1.03780839342631 bayes_pls_golite062009
deacetylase activity 0.690301184840273 bayes_pls_golite062009
general RNA polymerase II transcription factor activity 0.187173982490585 bayes_pls_golite062009
transcription activator activity 0.174325083775401 bayes_pls_golite062009
transcription factor binding 0.14097776282047 bayes_pls_golite062009
chromatin binding 0.123933030155299 bayes_pls_golite062009

Predicted Domain #4
Region A:
Residues: [419-652]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VYIPQYNNNG KGNGTSTKAG GGIYNGTTNG STDLSSNGKP CESCGTTKSS QWNSVSSGHS  60
   61 TSRLCLSCWE YWRRYGSMKS ATKGDAGEGD AKKKSSSAAS TPTATLAGLA TTPTAVVDLN 120
  121 DDEKISDLTN RQLHRCSIVN CGKEFKLKTH LARHYAQAHG IAISSGSPRP IMKTRTAFYL 180
  181 HTNPMTRVAR AICRSIVKPK KAARQSAYAI NAMLVKQEFT NRISGKSQAE IKKL

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #5
Region A:
Residues: [653-880]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LLLKPKDRGS VTKIANRLGA PGSGPHEWLV LTPKDKMPLP AVVSFPKPPK APDGSLVYDR  60
   61 VPNKSPDVVA VPADKELTII PTQATSTIRK RAHEDQQLNG TEVTIVPSGP PAKRPNKDPM 120
  121 PSHCPSPEQF AAMMAASGQP LSRHHLNGKQ KIAQMARGGN GRKQVISWMD APDDVYFRAN 180
  181 DTHKKTRKIL SAVDLRRAAR KPWRTLPIKP AAPEPSSRPI ESQIVILD

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.


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Created and Maintained by: Michael Riffle