YRC Public Data Repository - Protein Structure Prediction

Protein:	Roc1b-PA
Organism:	Drosophila melanogaster
Length:	122 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for Roc1b-PA.

Description	E-value	Query Range	Subject Range
gi\|50728692 - gi\|50728692\|ref\|XP_416239.1\| PREDICTED: similar to RBX1 protein [Gallus gallus]	100.0	[0..9]	[121..242]
gi\|112821040 - gi\|112821040\|gb\|ABI24165.1\| ring box protein 1 [Branchiostoma belcheri tsingtaunese] gi\|229296851, gi... - gi\|229296851\|gb\|EEN67490.1\| hypothetical protein BRAFLDRAFT_113519 [Branchiostoma floridae], gi\|2194...	99.0	[0..17]	[121..5]
gi\|67607511 - gi\|67607511\|ref\|XP_666816.1\| ring-box 1; RING box protein 1; regulator of cullins 1; RING finger pro... gi\|54657876 - gi\|54657876\|gb\|EAL36584.1\| ring-box 1; RING box protein 1; regulator of cullins 1; RING finger prote...	98.0	[0..1]	[122..1]
gi\|46228449 - gi\|46228449\|gb\|EAK89319.1\| RBX1 ortholog, RING finger [Cryptosporidium parvum Iowa II] gi\|66359646 - gi\|66359646\|ref\|XP_627001.1\| RBX1 ortholog, RING finger [Cryptosporidium parvum Iowa II]	97.0	[0..1]	[122..1]
gi\|19067884, gi\|... - gi\|62869880\|gb\|AAY18085.1\| hyperosmotic protein 21 [Salmo salar], gi\|62869878\|gb\|AAY18084.1\| hyperos...	97.0	[0..8]	[121..74]
gi\|50911983, gi\|... - gi\|50911983\|ref\|XP_467399.1\| putative RING box protein 1 [Oryza sativa (japonica cultivar-group)], g...	97.0	[0..21]	[121..12]
gi\|83701143 - gi\|83701143\|gb\|ABC41134.1\| RING-box protein [Arachis hypogaea]	96.0	[0..11]	[121..5]
gi\|78394982 - gi\|78394982\|gb\|AAI07832.1\| Rbx1 protein [Danio rerio]	96.0	[0..10]	[121..6]
gi\|114686561 - gi\|114686561\|ref\|XP_001167997.1\| PREDICTED: similar to RBX1 protein isoform 3 [Pan troglodytes]	96.0	[0..26]	[120..11]
gi\|159126214 - gi\|159126214\|gb\|EDP51330.1\| ubiquitin ligase subunit HrtA, putative [Aspergillus fumigatus A1163] gi\|66851689, gi\|... - gi\|70998662\|ref\|XP_754053.1\| ubiquitin ligase subunit HrtA [Aspergillus fumigatus Af293], gi\|6685168...	96.0	[0..33]	[122..30]

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Predicted Domain #1

Region A:
Residues: [1-122]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAEEIEVEET EDFHDMDFND EEPSCSGGAV QARTERFVVK KWVAHAMWGW DVAVDNCAIC  60
   61 RNHIMNLCIE CQADPNANQD ECTVAWGECN HAFHYHCIAR WLKTRLVCPL DNKEWVYQKY 120
  121 GR

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	20.154902
Match:	1u6gB
Description:	Crystal Structure of The Cand1-Cul1-Roc1 Complex
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
ubiquitin-protein ligase activity	10.2497392096259	bayes_pls_golite062009
small conjugating protein ligase activity	10.0460587929138	bayes_pls_golite062009
acid-amino acid ligase activity	8.99384576623969	bayes_pls_golite062009
ligase activity, forming carbon-nitrogen bonds	7.6988425139962	bayes_pls_golite062009
NEDD8 ligase activity	5.61847630780351	bayes_pls_golite062009
ligase activity	3.92677358871643	bayes_pls_golite062009
binding	2.78710909602478	bayes_pls_golite062009
protein binding	1.5975811408548	bayes_pls_golite062009
small conjugating protein-specific protease activity	1.2126425713931	bayes_pls_golite062009
ubiquitin-specific protease activity	1.03469202541773	bayes_pls_golite062009
transcription regulator activity	0.943706743211193	bayes_pls_golite062009
nucleic acid binding	0.708499177773075	bayes_pls_golite062009
hydrolase activity	0.52386813728704	bayes_pls_golite062009
cysteine-type peptidase activity	0.50197530717959	bayes_pls_golite062009
general RNA polymerase II transcription factor activity	0.392372133643049	bayes_pls_golite062009
DNA binding	0.365874679056682	bayes_pls_golite062009
ubiquitin thiolesterase activity	0.265769062717221	bayes_pls_golite062009
transcription factor binding	0.16916169785605	bayes_pls_golite062009
catalytic activity	0.14112008370434	bayes_pls_golite062009
enzyme binding	0.104373352314595	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: