YRC Public Data Repository - Protein Structure Prediction

Protein:	eIF-5A-PB, eIF-5A-PA
Organism:	Drosophila melanogaster
Length:	159 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for eIF-5A-PB, eIF-5A-PA.

Description	E-value	Query Range	Subject Range
gi\|114666486 - gi\|114666486\|ref\|XP_001174773.1\| PREDICTED: similar to eukaryotic initiation factor 5A isoform I var...	194.0	[0..1]	[156..133]
ANB1 - Translation elongation factor eIF-5A, previously thought to function in translation initiation; simi... gi\|151945115 - gi\|151945115\|gb\|EDN63366.1\| translation initiation factor eIF5A [Saccharomyces cerevisiae YJM789] gi\|190409524 - gi\|190409524\|gb\|EDV12789.1\| translation initiation factor eIF-5A [Saccharomyces cerevisiae RM11-1a] IF5A2_YEAST - Eukaryotic translation initiation factor 5A-2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288...	192.0	[0..1]	[158..1]
gi\|9295717 - gi\|9295717\|gb\|AAF87023.1\|AC006535_1 T24P13.1 [Arabidopsis thaliana]	192.0	[0..1]	[153..1]
IF5A_SPOEX - Eukaryotic translation initiation factor 5A OS=Spodoptera exigua GN=eIF-5A PE=2 SV=1 IF5A_SPOFR - Eukaryotic translation initiation factor 5A OS=Spodoptera frugiperda GN=eIF-5A PE=1 SV=1	190.0	[0..1]	[159..1]
gi\|47085971, gi\|... - gi\|47085971\|ref\|NP_998350.1\| eukaryotic translation initiation factor 5A [Danio rerio], gi\|45595729\|... gi\|166796796 - gi\|166796796\|gb\|AAI59303.1\| LOC100135249 protein [Xenopus tropicalis]	189.0	[0..1]	[156..1]
IF5A2_NICPL - Eukaryotic translation initiation factor 5A-2 OS=Nicotiana plumbaginifolia GN=EIF-5A2 PE=2 SV=1	189.0	[0..1]	[152..1]
gi\|91088683 - gi\|91088683\|ref\|XP_974942.1\| PREDICTED: similar to translation initiation factor 5a [Tribolium casta...	189.0	[0..1]	[159..1]
gi\|159130633 - gi\|159130633\|gb\|EDP55746.1\| Eukaryotic translation initiation factor eIF-5A [Aspergillus fumigatus A... gi\|66847788, gi\|... - gi\|70990614\|ref\|XP_750156.1\| Eukaryotic translation initiation factor eIF-5A [Aspergillus fumigatus ...	189.0	[0..6]	[156..41]

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Predicted Domain #1

Region A:
Residues: [1-159]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAELDDQFET TDSGASTTYP MQCSALRKNG FVMLKSRPCK IVEMSTSKTG KHGHAKVHMV  60
   61 GIDIFSNKKY EDICPSTHNM DVPNVKREDL QLIAISDDSF LTLMTESGDL REDLKVPEGE 120
  121 LGEQLRLDFD SGKDLLCTVL KACGEECVIA IKTNTALDK

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	37.522879
Match:	1xtdA
Description:	Structural Analysis of Leishmania mexicana eukaryotic initiation factor 5a
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
U6 snRNA binding	7.69488393698619	bayes_pls_golite062009
structural constituent of ribosome	6.60650180781768	bayes_pls_golite062009
structural molecule activity	6.0174879876147	bayes_pls_golite062009
translation initiation factor activity	5.09596850944863	bayes_pls_golite062009
nucleic acid binding	3.89165617439497	bayes_pls_golite062009
translation elongation factor activity	3.58178742491041	bayes_pls_golite062009
DNA binding	3.38561002225202	bayes_pls_golite062009
binding	2.83465364476231	bayes_pls_golite062009
RNA binding	1.76502371106766	bayes_pls_golite062009
sequence-specific DNA binding	1.74890841494748	bayes_pls_golite062009
transcription regulator activity	1.69669059514663	bayes_pls_golite062009
structure-specific DNA binding	1.54386990150255	bayes_pls_golite062009
translation regulator activity	1.46320772716954	bayes_pls_golite062009
translation factor activity, nucleic acid binding	1.40718318783582	bayes_pls_golite062009
single-stranded DNA binding	1.38349489974693	bayes_pls_golite062009
protein binding	1.20309946451799	bayes_pls_golite062009
transcription activator activity	0.990244702925461	bayes_pls_golite062009
mRNA binding	0.883475899526061	bayes_pls_golite062009
transcription factor activity	0.859071050218437	bayes_pls_golite062009
telomeric DNA binding	0.594907498313479	bayes_pls_golite062009
aminoacyl-tRNA ligase activity	0.474251377131502	bayes_pls_golite062009
ligase activity, forming carbon-oxygen bonds	0.47336621289748	bayes_pls_golite062009
ligase activity, forming aminoacyl-tRNA and related compounds	0.47336621289748	bayes_pls_golite062009
RNA polymerase activity	0.39251242706379	bayes_pls_golite062009
DNA-directed RNA polymerase activity	0.39251242706379	bayes_pls_golite062009
ribonuclease activity	0.35186207828037	bayes_pls_golite062009
nuclease activity	0.26446253803519	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: