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View Structure Prediction Details

Protein: retn-PA
Organism: Drosophila melanogaster
Length: 906 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for retn-PA.

Description E-value Query
Range
Subject
Range
retn-PB - The gene retained is referred to in FlyBase by the symbol Dmel\retn (CG5403, FBgn0004795). It is a p...
249.0 [0..1] [906..1]

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Predicted Domain #1
Region A:
Residues: [1-161]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MQLRVHPTMD CSGRSTSNIE RDSDLGDDLS HGDRTDDEMR DCDSVDGEHH QLSAKAAIAA  60
   61 RLSHTVSGGG GSFASPEPQT ELPLSHHHQL PPNHPLNALG SFMGIGGLHS IPNLQHSDVL 120
  121 EKLKMQVRDM KVGLMEQDYA AAAHAAAFGA NMLPTTISSG F

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [162-281]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PLPHNSVAFG HVTSSPSGGN GSSYNGGTTP TNSSNSNATT NGGGTAGPGG TGGSGGGGGG  60
   61 GGGGGGGVGG HQFSFASPTA APSGKEANSA SNSSTSSEAS NSSQQNNGWS FEEQFKQVRQ 120
  121 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 6.0
Match: 1m2vB
Description: Sec24
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [282-405]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LYEINDDPKR KEFLDDLFSF MQKRGTPINR LPIMAKSVLD LYELYNLVIA RGGLVDVINK  60
   61 KLWQEIIKGL HLPSSITSAA FTLRTQYMKY LYPYECEKKN LSTPAELQAA IDGNRREGRR 120
  121 SSYG

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 18.0
Match: 1kqqA
Description: DNA-binding domain from the dead ringer protein
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 4.55411292098115 bayes_pls_golite062009
DNA binding 4.42692928312159 bayes_pls_golite062009
nucleic acid binding 4.31553768044343 bayes_pls_golite062009
transcription activator activity 3.52298398128865 bayes_pls_golite062009
binding 2.97217702905299 bayes_pls_golite062009
transcription repressor activity 2.80681923216447 bayes_pls_golite062009
transcription factor activity 2.58593134374376 bayes_pls_golite062009
protein binding 1.76687312643483 bayes_pls_golite062009
transcription factor binding 1.28734696305262 bayes_pls_golite062009
transcription cofactor activity 1.13378621684772 bayes_pls_golite062009
RNA polymerase II transcription factor activity 1.06026105710513 bayes_pls_golite062009
transcription coactivator activity 1.04454363470311 bayes_pls_golite062009
general RNA polymerase II transcription factor activity 0.46237393414621 bayes_pls_golite062009

Predicted Domain #4
Region A:
Residues: [406-624]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QYEAMHNQMP MTPISRPSLP GGMQQMSPLA LVTHAAVANN QQAQAAAAAA AAHHRLMGAP  60
   61 AFGQMPNLVK QEIESRMMEY LQLIQAKKEQ GMPPVLGGNH PHQQQHSQQQ QQQQHHHQQQ 120
  121 QQQQSQQQHH LQQQRQRSQS PDLSKHEALS AQVALWHMYH NNNSPPGSAH TSPQQREALN 180
  181 LSDSPPNLTN IKREREREPT PEPVDQDDKF VDQPPPAKR

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #5
Region A:
Residues: [625-735]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VGSGLLPPGF PANFYLNPHN MAAVAAAAGF HHPSMGHQQD AASEGEPEDD YAHGEHNTTG  60
   61 NSSSMHDDSE PQQMNGHHHH QTHHLDKSDD SAIENSPTTS TTTGGSVGHR H

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #6
Region A:
Residues: [736-906]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SSPVSTKKKG GAKPQSGGKD VPTEDKDASS SGKLNPLETL SLLSGMQFQV ARNGTGDNGE  60
   61 PQLIVNLELN GVKYSGVLVA NVPLSQSETR TSSPCHAEAP TVEEEKDEEE EEEPKAAEEE 120
  121 SHRSPVKQEN EDVDQDMEGS EVLLNGGASA VGGAGAGVGV GVPLLKDAVV S

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


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Created and Maintained by: Michael Riffle