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View Structure Prediction Details

Protein: retn-PA
Organism: Drosophila melanogaster
Length: 906 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for retn-PA.

Description E-value Query
Range
Subject
Range
retn-PB - The gene retained is referred to in FlyBase by the symbol Dmel\retn (CG5403, FBgn0004795). It is a p...
249.0 [0..1] [906..1]

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Predicted Domain #1
Region A:
Residues: [1-161]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MQLRVHPTMD CSGRSTSNIE RDSDLGDDLS HGDRTDDEMR DCDSVDGEHH QLSAKAAIAA  60
   61 RLSHTVSGGG GSFASPEPQT ELPLSHHHQL PPNHPLNALG SFMGIGGLHS IPNLQHSDVL 120
  121 EKLKMQVRDM KVGLMEQDYA AAAHAAAFGA NMLPTTISSG F

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [162-281]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PLPHNSVAFG HVTSSPSGGN GSSYNGGTTP TNSSNSNATT NGGGTAGPGG TGGSGGGGGG  60
   61 GGGGGGGVGG HQFSFASPTA APSGKEANSA SNSSTSSEAS NSSQQNNGWS FEEQFKQVRQ 120
  121 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 6.0
Match: 1m2vB
Description: Sec24
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [282-405]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LYEINDDPKR KEFLDDLFSF MQKRGTPINR LPIMAKSVLD LYELYNLVIA RGGLVDVINK  60
   61 KLWQEIIKGL HLPSSITSAA FTLRTQYMKY LYPYECEKKN LSTPAELQAA IDGNRREGRR 120
  121 SSYG

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 18.0
Match: 1kqqA
Description: DNA-binding domain from the dead ringer protein
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 4.55411292098115 bayes_pls_golite062009
DNA binding 4.42692928312159 bayes_pls_golite062009
nucleic acid binding 4.31553768044343 bayes_pls_golite062009
transcription activator activity 3.52298398128865 bayes_pls_golite062009
binding 2.97217702905299 bayes_pls_golite062009
transcription repressor activity 2.80681923216447 bayes_pls_golite062009
transcription factor activity 2.58593134374376 bayes_pls_golite062009
protein binding 1.76687312643483 bayes_pls_golite062009
transcription factor binding 1.28734696305262 bayes_pls_golite062009
transcription cofactor activity 1.13378621684772 bayes_pls_golite062009
RNA polymerase II transcription factor activity 1.06026105710513 bayes_pls_golite062009
transcription coactivator activity 1.04454363470311 bayes_pls_golite062009
general RNA polymerase II transcription factor activity 0.46237393414621 bayes_pls_golite062009

Predicted Domain #4
Region A:
Residues: [406-624]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QYEAMHNQMP MTPISRPSLP GGMQQMSPLA LVTHAAVANN QQAQAAAAAA AAHHRLMGAP  60
   61 AFGQMPNLVK QEIESRMMEY LQLIQAKKEQ GMPPVLGGNH PHQQQHSQQQ QQQQHHHQQQ 120
  121 QQQQSQQQHH LQQQRQRSQS PDLSKHEALS AQVALWHMYH NNNSPPGSAH TSPQQREALN 180
  181 LSDSPPNLTN IKREREREPT PEPVDQDDKF VDQPPPAKR

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #5
Region A:
Residues: [625-735]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VGSGLLPPGF PANFYLNPHN MAAVAAAAGF HHPSMGHQQD AASEGEPEDD YAHGEHNTTG  60
   61 NSSSMHDDSE PQQMNGHHHH QTHHLDKSDD SAIENSPTTS TTTGGSVGHR H

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #6
Region A:
Residues: [736-906]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SSPVSTKKKG GAKPQSGGKD VPTEDKDASS SGKLNPLETL SLLSGMQFQV ARNGTGDNGE  60
   61 PQLIVNLELN GVKYSGVLVA NVPLSQSETR TSSPCHAEAP TVEEEKDEEE EEEPKAAEEE 120
  121 SHRSPVKQEN EDVDQDMEGS EVLLNGGASA VGGAGAGVGV GVPLLKDAVV S

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.


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Created and Maintained by: Michael Riffle