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View Structure Prediction Details

Protein: grau-PA
Organism: Drosophila melanogaster
Length: 570 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for grau-PA.

Description E-value Query
Range		 Subject
Range
gi|76651068 - gi|76651068|ref|XP_887912.1| PREDICTED: similar to zinc finger protein 192 isoform 5 [Bos taurus]
 694.0 [0..12] [570..319]

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Predicted Domain #1
Region A:
Residues: [1-89] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDICRLCLRG VSGAQMCLQI FDVDSGESKV AEVLRQHFWF EVLPNDEISK VICNVCWTQV  60
   61 SEFHQFYVSI QEAQVIYATT SKFKQDPEM

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 3.36
Match: 1pzwA
Description: Crystal structure of the zinc finger associated domain of the Drosophila transcription factor Grauzone
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 3.84932768708444 bayes_pls_golite062009
DNA binding 3.45124926204188 bayes_pls_golite062009
nucleic acid binding 3.34875987514951 bayes_pls_golite062009
binding 2.8684204787273 bayes_pls_golite062009
transcription factor activity 2.74592237402384 bayes_pls_golite062009
RNA polymerase II transcription factor activity 2.23212813739998 bayes_pls_golite062009
transcription repressor activity 1.83119162033863 bayes_pls_golite062009
general RNA polymerase II transcription factor activity 1.66264161250652 bayes_pls_golite062009
transcription activator activity 1.45965791386122 bayes_pls_golite062009
sequence-specific DNA binding 1.44741411126911 bayes_pls_golite062009
protein binding 1.30321965120678 bayes_pls_golite062009
transcription factor binding 1.22761682002 bayes_pls_golite062009
ligand-dependent nuclear receptor activity 1.1269808729848 bayes_pls_golite062009
structural constituent of ribosome 1.0478696280786 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 1.02819346233483 bayes_pls_golite062009
structural molecule activity 0.958501322313092 bayes_pls_golite062009
transcription cofactor activity 0.449959641856445 bayes_pls_golite062009
catalytic activity 0.133319360419662 bayes_pls_golite062009
cytoskeletal protein binding 0.0220126735489528 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [90-172] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VNTSWPEEVL MPADVLAVDN DVGAQINVNP LDELDLSQPM SPEDSKVGIK TERQSPDMEL  60
   61 LFEDANNEQD EDYEDDEDDD TDD

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [173-339] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LIVTRSGRKR KRDVAKPAKT KRGTVSVGRK GKEKMVVKRG PPKRIFKMER LPPFCKEDEE  60
   61 LIKRYIVMGC ELCIFLAEDF DGIREHFKDK HPDERPYIKC CGRKLNKRCL IQEHARRHEN 120
  121 PEYIKCKDCG KVFANSSVLR AHWLVHHVPD EECDFQCEDC GKRFSRR

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 15.0
Match: 2cshA
Description: Solution structure of tandem repeat of the zf-C2H2 domains of human zinc finger protein 297B
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 4.70988788192472 bayes_pls_golite062009
nucleic acid binding 4.58713908116892 bayes_pls_golite062009
DNA binding 4.56219307357342 bayes_pls_golite062009
transcription factor activity 3.50954949535763 bayes_pls_golite062009
transcription repressor activity 3.27542149084008 bayes_pls_golite062009
RNA polymerase II transcription factor activity 3.22082323675675 bayes_pls_golite062009
binding 3.10743787485868 bayes_pls_golite062009
transcription activator activity 2.19952417915035 bayes_pls_golite062009
chromatin binding 2.18464662431232 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 1.63161912031789 bayes_pls_golite062009
sequence-specific DNA binding 1.42975942698743 bayes_pls_golite062009
transcription factor binding 1.39608963544799 bayes_pls_golite062009
transcription corepressor activity 1.34049786451995 bayes_pls_golite062009
protein binding 1.00484935878505 bayes_pls_golite062009
transcription cofactor activity 0.77874411480713 bayes_pls_golite062009
catalytic activity 0.245893663605433 bayes_pls_golite062009
structure-specific DNA binding 0.240825841910931 bayes_pls_golite062009
double-stranded DNA binding 0.0129353639725593 bayes_pls_golite062009

Predicted Domain #4
Region A:
Residues: [340-570] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NLLELHKGSH VPVNERKFIC PQCPKHNAFA TEYHMQVHIS MQHRKAANIC HVCGKKIKDK  60
   61 AVFEKHVRLH FEESGPRIKC PRPDCESWLK DEDNLKQHLR RHNDEGKLFI CSECGKSCKN 120
  121 SRALIGHKRY SHSNVIYTCE QCGKTFKKDI SLKEHMAQHT GEPLYKCPFC PRTFNSNANM 180
  181 HSHKKKMHPV EWDIWRKTKT GSSQKVLPSA QVAQMFRDDA DVAAIANDYS G

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 57.0
Match: 2i13A
Description: No description for 2i13A was found.
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle