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View Structure Prediction Details

Protein: grau-PA
Organism: Drosophila melanogaster
Length: 570 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for grau-PA.

Description E-value Query
Range		 Subject
Range
gi|76651068 - gi|76651068|ref|XP_887912.1| PREDICTED: similar to zinc finger protein 192 isoform 5 [Bos taurus]
 694.0 [0..12] [570..319]

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Predicted Domain #1
Region A:
Residues: [1-89] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDICRLCLRG VSGAQMCLQI FDVDSGESKV AEVLRQHFWF EVLPNDEISK VICNVCWTQV  60
   61 SEFHQFYVSI QEAQVIYATT SKFKQDPEM

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 3.36
Match: 1pzwA
Description: Crystal structure of the zinc finger associated domain of the Drosophila transcription factor Grauzone
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 3.84932768708444 bayes_pls_golite062009
DNA binding 3.45124926204188 bayes_pls_golite062009
nucleic acid binding 3.34875987514951 bayes_pls_golite062009
binding 2.8684204787273 bayes_pls_golite062009
transcription factor activity 2.74592237402384 bayes_pls_golite062009
RNA polymerase II transcription factor activity 2.23212813739998 bayes_pls_golite062009
transcription repressor activity 1.83119162033863 bayes_pls_golite062009
general RNA polymerase II transcription factor activity 1.66264161250652 bayes_pls_golite062009
transcription activator activity 1.45965791386122 bayes_pls_golite062009
sequence-specific DNA binding 1.44741411126911 bayes_pls_golite062009
protein binding 1.30321965120678 bayes_pls_golite062009
transcription factor binding 1.22761682002 bayes_pls_golite062009
ligand-dependent nuclear receptor activity 1.1269808729848 bayes_pls_golite062009
structural constituent of ribosome 1.0478696280786 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 1.02819346233483 bayes_pls_golite062009
structural molecule activity 0.958501322313092 bayes_pls_golite062009
transcription cofactor activity 0.449959641856445 bayes_pls_golite062009
catalytic activity 0.133319360419662 bayes_pls_golite062009
cytoskeletal protein binding 0.0220126735489528 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [90-172] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VNTSWPEEVL MPADVLAVDN DVGAQINVNP LDELDLSQPM SPEDSKVGIK TERQSPDMEL  60
   61 LFEDANNEQD EDYEDDEDDD TDD

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [173-339] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LIVTRSGRKR KRDVAKPAKT KRGTVSVGRK GKEKMVVKRG PPKRIFKMER LPPFCKEDEE  60
   61 LIKRYIVMGC ELCIFLAEDF DGIREHFKDK HPDERPYIKC CGRKLNKRCL IQEHARRHEN 120
  121 PEYIKCKDCG KVFANSSVLR AHWLVHHVPD EECDFQCEDC GKRFSRR

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 15.0
Match: 2cshA
Description: Solution structure of tandem repeat of the zf-C2H2 domains of human zinc finger protein 297B
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 4.70988788192472 bayes_pls_golite062009
nucleic acid binding 4.58713908116892 bayes_pls_golite062009
DNA binding 4.56219307357342 bayes_pls_golite062009
transcription factor activity 3.50954949535763 bayes_pls_golite062009
transcription repressor activity 3.27542149084008 bayes_pls_golite062009
RNA polymerase II transcription factor activity 3.22082323675675 bayes_pls_golite062009
binding 3.10743787485868 bayes_pls_golite062009
transcription activator activity 2.19952417915035 bayes_pls_golite062009
chromatin binding 2.18464662431232 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 1.63161912031789 bayes_pls_golite062009
sequence-specific DNA binding 1.42975942698743 bayes_pls_golite062009
transcription factor binding 1.39608963544799 bayes_pls_golite062009
transcription corepressor activity 1.34049786451995 bayes_pls_golite062009
protein binding 1.00484935878505 bayes_pls_golite062009
transcription cofactor activity 0.77874411480713 bayes_pls_golite062009
catalytic activity 0.245893663605433 bayes_pls_golite062009
structure-specific DNA binding 0.240825841910931 bayes_pls_golite062009
double-stranded DNA binding 0.0129353639725593 bayes_pls_golite062009

Predicted Domain #4
Region A:
Residues: [340-570] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NLLELHKGSH VPVNERKFIC PQCPKHNAFA TEYHMQVHIS MQHRKAANIC HVCGKKIKDK  60
   61 AVFEKHVRLH FEESGPRIKC PRPDCESWLK DEDNLKQHLR RHNDEGKLFI CSECGKSCKN 120
  121 SRALIGHKRY SHSNVIYTCE QCGKTFKKDI SLKEHMAQHT GEPLYKCPFC PRTFNSNANM 180
  181 HSHKKKMHPV EWDIWRKTKT GSSQKVLPSA QVAQMFRDDA DVAAIANDYS G

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 57.0
Match: 2i13A
Description: No description for 2i13A was found.
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle