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View Structure Prediction Details

Protein: gi|123998707, gi...
Organism: synthetic construct
Length: 634 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|123998707, gi....

Description E-value Query
Range
Subject
Range
gi|114615760 - gi|114615760|ref|XP_519345.2| PREDICTED: hypothetical protein isoform 3 [Pan troglodytes]
0.0 [1..634] [1..634]
gi|7022355, gi|1... - gi|7022355|dbj|BAA91568.1| unnamed protein product [Homo sapiens], gi|13123774|ref|NP_056265.1| prot...
0.0 [1..634] [1..634]
gi|55731017 - gi|55731017|emb|CAH92225.1| hypothetical protein [Pongo abelii]
gi|197100398 - gi|197100398|ref|NP_001127526.1| POT1 protection of telomeres 1 homolog [Pongo abelii]
0.0 [1..634] [1..634]
gi|109068051, gi... - gi|109068051|ref|XP_001087820.1| PREDICTED: protection of telomeres 1 isoform 2 [Macaca mulatta], gi...
0.0 [1..634] [1..634]
POTE1_MACFA - Protection of telomeres protein 1 OS=Macaca fascicularis GN=POT1 PE=2 SV=1
0.0 [1..634] [1..634]
POTE1_MOUSE - Protection of telomeres protein 1 OS=Mus musculus GN=Pot1 PE=1 SV=1
0.0 [1..634] [1..640]
gi|73975944 - gi|73975944|ref|XP_851415.1| PREDICTED: similar to Protection of telomeres 1 (hPot1) (POT1-like telo...
0.0 [1..634] [302..942]
gi|109486528 - gi|109486528|ref|XP_001058464.1| PREDICTED: similar to Protection of telomeres 1 (hPot1) (POT1-like ...
0.0 [4..634] [328..960]

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Predicted Domain #1
Region A:
Residues: [1-332]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSLVPATNYI YTPLNQLKGG TIVNVYGVVK FFKPPYLSKG TDYCSVVTIV DQTNVKLTCL  60
   61 LFSGNYEALP IIYKNGDIVR FHRLKIQVYK KETQGITSSG FASLTFEGTL GAPIIPRTSS 120
  121 KYFNFTTEDH KMVEALRVWA STHMSPSWTL LKLCDVQPMQ YFDLTCQLLG KAEVDGASFL 180
  181 LKVWDGTRTP FPSWRVLIQD LVLEGDLSHI HRLQNLTIDI LVYDNHVHVA RSLKVGSFLR 240
  241 IYSLHTKLQS MNSENQTMLS LEFHLHGGTS YGRGIRVLPE SNSDVDQLKK DLESANLTAN 300
  301 QHSDVICQSE PDDSFPSSGS VSLYEVERCQ QL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 124.0
Match: 1xjvA
Description: Crystal structure of human POT1 bound to telomeric single-stranded DNA (TTAGGGTTAG)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
telomerase inhibitor activity 8.08322438894165 bayes_pls_golite062009
single-stranded telomeric DNA binding 7.13197590913268 bayes_pls_golite062009
telomeric DNA binding 7.07761964836826 bayes_pls_golite062009
DEAD/H-box RNA helicase binding 4.55461999169159 bayes_pls_golite062009
nucleic acid binding 3.99127970564994 bayes_pls_golite062009
DNA binding 3.53568546959418 bayes_pls_golite062009
structure-specific DNA binding 3.53214384646348 bayes_pls_golite062009
single-stranded DNA binding 3.49337353583487 bayes_pls_golite062009
binding 2.83465364476231 bayes_pls_golite062009
structural constituent of ribosome 2.13063800565247 bayes_pls_golite062009
structural molecule activity 1.9177190829469 bayes_pls_golite062009
transcription regulator activity 1.84350127337404 bayes_pls_golite062009
protein binding 1.20309946451799 bayes_pls_golite062009
DNA helicase activity 1.12203697857261 bayes_pls_golite062009
transcription repressor activity 1.11836126147719 bayes_pls_golite062009
transcription activator activity 1.09079153283893 bayes_pls_golite062009
nucleotidyltransferase activity 0.961606389385315 bayes_pls_golite062009
transcription factor activity 0.952569279670437 bayes_pls_golite062009
sequence-specific DNA binding 0.85691075793641 bayes_pls_golite062009
RNA polymerase activity 0.79554655100991 bayes_pls_golite062009
DNA-directed RNA polymerase activity 0.79554655100991 bayes_pls_golite062009
DNA-dependent ATPase activity 0.638831894247026 bayes_pls_golite062009
ribonuclease activity 0.62994126331969 bayes_pls_golite062009
nuclease activity 0.57381531077345 bayes_pls_golite062009
translation regulator activity 0.515576958825022 bayes_pls_golite062009
translation factor activity, nucleic acid binding 0.468402630523277 bayes_pls_golite062009
double-stranded DNA binding 0.378383789953688 bayes_pls_golite062009
exonuclease activity 0.28313884527829 bayes_pls_golite062009
translation initiation factor activity 0.2080607201312 bayes_pls_golite062009
four-way junction helicase activity 0.13147110156029 bayes_pls_golite062009
ATP-dependent DNA helicase activity 0.0179535526984695 bayes_pls_golite062009
helicase activity 0.0121541775159524 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [333-504]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SATILTDHQY LERTPLCAIL KQKAPQQYRI RAKLRSYKPR RLFQSVKLHC PKCHLLQEVP  60
   61 HEGDLDIIFQ DGATKTPDVK LQNTSLYDSK IWTTKNQKGR KVAVHFVKNN GILPLSNECL 120
  121 LLIEGGTLSE ICKLSNKFNS VIPVRSGHED LELLDLSAPF LIQGTIHHYG CK

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [505-634]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QCSSLRSIQN LNSLVDKTSW IPSSVAEALG IVPLQYVFVM TFTLDDGTGV LEAYLMDSDK  60
   61 FFQIPASEVL MDDDLQKSVD MIMDMFCPPG IKIDAYPWLE CFIKSYNVTN GTDNQICYQI 120
  121 FDTTVAEDVI 

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle