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View Structure Prediction Details

Protein: PPIC_MOUSE
Organism: Mus musculus
Length: 212 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PPIC_MOUSE.

Description E-value Query
Range
Subject
Range
gi|50301248 - gi|50301248|gb|AAT73777.1| TRIM5/cyclophilin A fusion protein [Aotus trivirgatus]
271.0 [0..25] [199..301]
gi|60653277 - gi|60653277|gb|AAX29333.1| peptidylprolyl isomerase B [synthetic construct]
262.0 [0..2] [209..7]
gi|109081474 - gi|109081474|ref|XP_001106590.1| PREDICTED: similar to peptidylprolyl isomerase B precursor isoform ...
gi|123997625, gi... - gi|60656329|gb|AAX32728.1| peptidylprolyl isomerase B [synthetic construct], gi|123997625|gb|ABM8641...
PPIB - peptidylprolyl isomerase B (cyclophilin B)
261.0 [0..2] [209..7]
PPIB_RAT - Peptidyl-prolyl cis-trans isomerase B OS=Rattus norvegicus GN=Ppib PE=1 SV=3
261.0 [0..2] [209..7]
gi|74000476 - gi|74000476|ref|XP_852389.1| PREDICTED: similar to peptidylprolyl isomerase B precursor isoform 2 [C...
260.0 [0..2] [209..7]
PPIB_BOVIN - Peptidyl-prolyl cis-trans isomerase B OS=Bos taurus GN=PPIB PE=1 SV=4
260.0 [0..2] [209..7]
CCDS10191.1_1 - null
gi|114657576 - gi|114657576|ref|XP_001174161.1| PREDICTED: peptidylprolyl isomerase B [Pan troglodytes]
259.0 [0..2] [209..7]
gi|32484306, gi|... - gi|32484306|gb|AAH54168.1| Ppib-prov protein [Xenopus laevis], gi|148237181|ref|NP_001080505.1| pept...
259.0 [0..2] [209..7]

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Predicted Domain #1
Region A:
Residues: [1-212]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSPGPRLLLP AVLCLGLGAL VSSSGSSGVR KRGPSVTDKV FFDVRIGDKD VGRIVIGLFG  60
   61 NVVPKTVENF VALATGEKGY GYKGSIFHRV IKDFMIQGGD FTARDGTGGM SIYGETFPDE 120
  121 NFKLKHYGIG WVSMANAGPD TNGSQFFITL TKPTWLDGKH VVFGKVLDGM TVVHSIELQA 180
  181 TDGHDRPLTD CTIVNSGKID VKTPFVVEVP DW

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 60.0
Match: 2rmcA
Description: Cyclophilin (eukaryotic)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
protein deacetylase activity 4.3775483906311 bayes_pls_golite062009
histone deacetylase activity 4.29026678196473 bayes_pls_golite062009
peptidyl-prolyl cis-trans isomerase activity 3.73853378771688 bayes_pls_golite062009
cis-trans isomerase activity 3.66963215732405 bayes_pls_golite062009
deacetylase activity 3.49940864924766 bayes_pls_golite062009
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides 3.01511519120932 bayes_pls_golite062009
RNA binding 2.94609837984526 bayes_pls_golite062009
isomerase activity 1.96529188741504 bayes_pls_golite062009
binding 1.46018233647024 bayes_pls_golite062009
mRNA binding 1.45537055700871 bayes_pls_golite062009
unfolded protein binding 1.38124355054041 bayes_pls_golite062009
nucleic acid binding 0.939772862764466 bayes_pls_golite062009
catalytic activity 0.748655649755714 bayes_pls_golite062009
hydrolase activity 0.493806105600863 bayes_pls_golite062009
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 0.408539130322443 bayes_pls_golite062009
drug binding 0.36339132904137 bayes_pls_golite062009
ubiquitin-protein ligase activity 0.322244688184474 bayes_pls_golite062009
small conjugating protein ligase activity 0.286133802341887 bayes_pls_golite062009
histone binding 0.268719695649015 bayes_pls_golite062009
protein binding 0.130251391659493 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle