YRC Public Data Repository - Protein Structure Prediction

Protein:	UB2E2_MOUSE
Organism:	Mus musculus
Length:	201 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for UB2E2_MOUSE.

Description	E-value	Query Range	Subject Range
gi\|149729828 - gi\|149729828\|ref\|XP_001494974.1\| PREDICTED: similar to UB2E2 [Equus caballus] CCDS2637.1_1 - null gi\|114585697 - gi\|114585697\|ref\|XP_530592.2\| PREDICTED: hypothetical protein [Pan troglodytes] UBE2E2 - ubiquitin-conjugating enzyme E2E 2 (UBC4/5 homolog, yeast) gi\|149039992, gi... - gi\|149039992\|gb\|EDL94076.1\| ubiquitin-conjugating enzyme E2E 2 (UBC4/5 homolog, yeast), isoform CRA_... gi\|109050845 - gi\|109050845\|ref\|XP_001089978.1\| PREDICTED: similar to ubiquitin-conjugating enzyme E2E 2 (UBC4/5 ho...	240.0	[0..1]	[201..1]
gi\|109501290 - gi\|109501290\|ref\|XP_341289.3\| PREDICTED: similar to ubiquitin-conjugating enzyme E2E 2 (UBC4/5 homol...	240.0	[0..1]	[201..25]
gi\|118403846, gi... - gi\|118403846\|ref\|NP_001072140.1\| UB2E2 [Sus scrofa], gi\|115371731\|gb\|ABI96190.1\| UB2E2 [Sus scrofa]	237.0	[0..1]	[201..1]
gi\|52354679, gi\|... - gi\|52354679\|gb\|AAH82942.1\| LOC494805 protein [Xenopus laevis], gi\|148233776\|ref\|NP_001088106.1\| hypo... gi\|187607782, gi... - gi\|187607782\|ref\|NP_001119983.1\| ubiquitin-conjugating enzyme E2E 2 [Xenopus (Silurana) tropicalis],...	235.0	[0..1]	[201..1]
gi\|73989346 - gi\|73989346\|ref\|XP_852428.1\| PREDICTED: similar to ubiquitin-conjugating enzyme E2E 2 (UBC4/5 homolo...	228.0	[0..1]	[201..1]
gi\|50370097, gi\|... - gi\|51011079\|ref\|NP_001003494.1\| ubiquitin-conjugating enzyme E2E 2 [Danio rerio], gi\|50370097\|gb\|AAH...	220.0	[0..1]	[201..1]
gi\|1072386 - gi\|1072386\|emb\|CAA63352.1\| ubiquitin-conjugating enzyme UbcM2 [Mus musculus]	214.0	[0..1]	[201..1]

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Predicted Domain #1

Region A:
Residues: [1-201]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSTEAQRVDD SPSTSGGSSD GDQRESVQQE PDREQVQPKK KEGKISSKTA AKLSTSAKRI  60
   61 QKELAEITLD PPPNCSAGPK GDNIYEWRST ILGPPGSVYE GGVFFLDITF SPDYPFKPPK 120
  121 VTFRTRIYHC NINSQGVICL DILKDNWSPA LTISKVLLSI CSLLTDCNPA DPLVGSIATQ 180
  181 YMTNRAEHDR MARQWTKRYA T

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	50.522879
Match:	1y6lA
Description:	Human ubiquitin conjugating enzyme E2E2
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
ubiquitin-protein ligase activity	11.3486134076304	bayes_pls_golite062009
small conjugating protein ligase activity	11.2964721480824	bayes_pls_golite062009
acid-amino acid ligase activity	10.2401422444624	bayes_pls_golite062009
ligase activity, forming carbon-nitrogen bonds	8.93602533934698	bayes_pls_golite062009
ligase activity	5.17219147802758	bayes_pls_golite062009
SUMO ligase activity	3.88357560284404	bayes_pls_golite062009
ISG15 ligase activity	3.37361650623694	bayes_pls_golite062009
HLH domain binding	2.41376652679018	bayes_pls_golite062009
transcription regulator activity	2.21355731489173	bayes_pls_golite062009
nucleic acid binding	2.13970605403492	bayes_pls_golite062009
DNA binding	1.95596447916631	bayes_pls_golite062009
protein binding	1.77678273247394	bayes_pls_golite062009
binding	1.75350658654805	bayes_pls_golite062009
transcription repressor activity	1.5236035191291	bayes_pls_golite062009
transcription activator activity	1.19240180311941	bayes_pls_golite062009
catalytic activity	0.891402822028799	bayes_pls_golite062009
NEDD8 ligase activity	0.715654744941217	bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor	0.58835335751383	bayes_pls_golite062009
kinase activity	0.519703305315987	bayes_pls_golite062009
protein kinase activity	0.443948654247666	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	0.373779304908933	bayes_pls_golite062009
protein serine/threonine kinase activity	0.182854082413338	bayes_pls_golite062009
transcription corepressor activity	0.122859425935324	bayes_pls_golite062009
transferase activity	0.0984525836903841	bayes_pls_golite062009
transcription factor binding	0.0104967529560147	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: