YRC Public Data Repository - Protein Structure Prediction

Protein:	IMB3_SCHPO
Organism:	Schizosaccharomyces pombe 972h-
Length:	1095 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for IMB3_SCHPO.

Description	E-value	Query Range	Subject Range
gi\|24797086, gi\|... - gi\|24797086\|ref\|NP_002262.3\| importin 5 [Homo sapiens], gi\|119629382\|gb\|EAX08977.1\| RAN binding prot...	523.0	[0..10]	[1092..26]
gi\|12057236 - gi\|12057236\|gb\|AAG45965.2\| Ran binding protein 5 [Mus musculus]	522.0	[0..10]	[1092..11]
gi\|73989213 - gi\|73989213\|ref\|XP_542647.2\| PREDICTED: similar to RAN binding protein 5 isoform 1 [Canis familiaris...	521.0	[0..10]	[1092..8]
gi\|109121146, gi... - gi\|109121146\|ref\|XP_001089272.1\| PREDICTED: similar to RAN binding protein 5 isoform 2 [Macaca mulat...	521.0	[0..10]	[1092..8]
gi\|109502015, gi... - gi\|109502869\|ref\|XP_001075101.1\| PREDICTED: similar to RAN binding protein 5 [Rattus norvegicus], gi...	520.0	[0..10]	[1092..8]
gi\|189091910 - gi\|189091910\|ref\|XP_001929788.1\| [Podospora anserina] gi\|27803065, gi\|... - gi\|27803065\|emb\|CAD60768.1\| unnamed protein product [Podospora anserina], gi\|188219308\|emb\|CAP49288....	513.0	[0..1]	[1095..1]

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Predicted Domain #1

Region A:
Residues: [1-821]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSGFPPEVL SPLLNLVQGL SSPDNTVRND AEKSLSSDWI SQRADLLLNG LAILAYQSED  60
   61 PAVRSFCLVL CRRISFRTLP GDSELEVFSS ISNESKQSLQ SQLLACFVKE SVPTVRNKLC 120
  121 DTIAEIARSI YDCQGEWPEL INVIFNAVNS PDESFRESVF RTITSLPRLL SGQDSAVTPL 180
  181 FTTGLADPSI RVRISAARAY SAVILESKQS TRDQVIPLLP SLMNILPPLQ QDRDSDNLAD 240
  241 CLMAITEIAE VFPKLFKPIF ESVIAFGLGI IKDKELDNSA RQAALELLVC FSEGAPAMCR 300
  301 KSSDYTDQLV LQCLLLMTDV AGDPEDEAEE LQEWLNTDDL DQDESDANHV VAEQAMDRLS 360
  361 RKLGGKTILP PSFTWLPRLI PSQKWSERHA ALMAISSIAE GAEKLMKKEL SRVLDMVLPL 420
  421 LADPHPRVRW AACNAVGQMS TDFAPDMQVK YPSRILEALV PVLESPESRV QAHAAAAMVN 480
  481 FSEEADNKVL EPYLDDILQR LLTLLQSPKR YVQEQAVTTI ATVADAAAKK FEKYFDAIMP 540
  541 LLFNVLQQAD GKEFRTLRGK TMECATLIAL AVGKQRFLPV SQELIQILGN IQMGITDSDD 600
  601 PQASYLISAW GRICRVLGSD FVPFLSSVMP PLLVAATSKP DFTIIDDEVD ESKYSEQDGW 660
  661 EFIPVHGQQV GIRTSTLEDK CTATEMLVCY AAELKADFDP YVNEVLTSVV LPGLKFFFHD 720
  721 GVRSACCKCI PQLLNARILA SNRDPAKVNE LWEPILRKLL DHIQNEPSVE MLADYFECFY 780
  781 QSLEISGLNL SPSSMEALVA AVDLQLKGFI SRVQQREEEA K

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	81.69897
Match:	2ot8A
Description:	No description for 2ot8A was found.

Predicted Domain #2

Region A:
Residues: [822-1095]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NGDIDIEEDE DMILAVENDQ NLLNEINKTF SVVLKIHKTA FCPFWERLLP YMDGFLSGND  60
   61 TVAKQWALCM MDDLIEFTGP DSWNYKDHFL PYLAEGIQSS EPEIRQAASY GIGVAAQHGG 120
  121 ELYAEICSSA LPALFKMLEL PDARDEEQIY ATENICVAIC KICRFCSQRV QDLDKVVTYW 180
  181 INTLPVTHDE DDAPYAYTFL AELMEQNHVA VASQMPTIIT ILAETFASGV LRGRTLTRLM 240
  241 EASKVYLARF PADQVNSVIA TLSVDNQRAL SAHF

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	34.39794
Match:	1q1sC
Description:	Mouse Importin alpha- phosphorylated SV40 CN peptide complex
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
protein transporter activity	4.58709163830613	bayes_pls_golite062009
binding	3.0667965351474	bayes_pls_golite062009
protein transmembrane transporter activity	2.74547353635661	bayes_pls_golite062009
transporter activity	2.48700774379895	bayes_pls_golite062009
substrate-specific transporter activity	2.26725422172281	bayes_pls_golite062009
nuclear export signal receptor activity	2.13470398426489	bayes_pls_golite062009
RNA binding	1.91507786651888	bayes_pls_golite062009
nuclear localization sequence binding	1.91487015967262	bayes_pls_golite062009
protein binding	1.73688475473996	bayes_pls_golite062009
transmembrane transporter activity	1.28481004323799	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	1.09652988954158	bayes_pls_golite062009
nucleic acid binding	1.00841167631924	bayes_pls_golite062009
signal transducer activity	0.662662274021266	bayes_pls_golite062009
molecular transducer activity	0.662662274021266	bayes_pls_golite062009
signal sequence binding	0.57106697498903	bayes_pls_golite062009
transcription regulator activity	0.385452858197632	bayes_pls_golite062009
mRNA binding	0.37278269424461	bayes_pls_golite062009
DNA binding	0.309260217284589	bayes_pls_golite062009
active transmembrane transporter activity	0.252495966234234	bayes_pls_golite062009
ion transmembrane transporter activity	0.248585912061178	bayes_pls_golite062009
primary active transmembrane transporter activity	0.226380819487924	bayes_pls_golite062009
P-P-bond-hydrolysis-driven transmembrane transporter activity	0.217517113570989	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances	0.178770060806735	bayes_pls_golite062009
ATPase activity, coupled to movement of substances	0.175241020572885	bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of substances	0.174922130116569	bayes_pls_golite062009
nucleoside-triphosphatase activity	0.100181463251306	bayes_pls_golite062009
pyrophosphatase activity	0.0635404099346928	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides	0.0548082069333885	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	0.052195223119721	bayes_pls_golite062009
cation transmembrane transporter activity	0.0405268469927988	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: