YRC Public Data Repository - Protein Structure Prediction

Protein:	PUS2_SCHPO
Organism:	Schizosaccharomyces pombe 972h-
Length:	451 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PUS2_SCHPO.

Description	E-value	Query Range	Subject Range
PUS1_ASHGO - tRNA pseudouridine synthase 1 OS=Ashbya gossypii GN=PUS1 PE=3 SV=1 PUS1_ASHGO - tRNA pseudouridine synthase 1 OS=Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL ...	358.0	[0..3]	[443..23]
gi\|25518568, gi\|... - gi\|9558589\|gb\|AAF88152.1\|AC026234_3 Contains similarity to a pseudouridine synthase 1 from Homo sapi...	331.0	[0..8]	[446..24]
gi\|88184224, gi\|... - gi\|88184224\|gb\|EAQ91692.1\| hypothetical protein CHGG_03627 [Chaetomium globosum CBS 148.51], gi\|1162...	329.0	[0..6]	[449..75]
pus1 - tRNA pseudouridylate synthase Lsp1 PUS1_SCHPO - tRNA pseudouridine synthase 1 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=pus1 PE=1 SV...	328.0	[0..7]	[449..18]
PUS1_CANGA - tRNA pseudouridine synthase 1 OS=Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622... PUS1_CANGA - tRNA pseudouridine synthase 1 OS=Candida glabrata GN=PUS1 PE=3 SV=1	328.0	[0..8]	[442..55]
gi\|42553476, gi\|... - gi\|46124417\|ref\|XP_386762.1\| hypothetical protein FG06586.1 [Gibberella zeae PH-1], gi\|42553476\|gb\|E...	326.0	[0..6]	[449..73]
PUS1_YEAST - tRNA pseudouridine synthase 1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=PUS1 PE=1 ... gi\|151942589 - gi\|151942589\|gb\|EDN60935.1\| tRNA-pseudouridine synthase [Saccharomyces cerevisiae YJM789] PUS1 - tRNA:pseudouridine synthase, introduces pseudouridines at positions 26-28, 34-36, 65, and 67 of tRNA... gi\|190407751 - gi\|190407751\|gb\|EDV11016.1\| tRNA pseudouridine synthase [Saccharomyces cerevisiae RM11-1a]	320.0	[0..10]	[442..52]
gi\|40738761, gi\|... - gi\|67539990\|ref\|XP_663769.1\| hypothetical protein AN6165.2 [Aspergillus nidulans FGSC A4], ref\|XP_41...	317.0	[0..5]	[449..39]
gi\|32414669, gi\|... - gi\|32414669\|ref\|XP_327814.1\| hypothetical protein [Neurospora crassa], gi\|28920438\|gb\|EAA29805.1\| hy... gi\|85091723 - gi\|85091723\|ref\|XP_959041.1\| hypothetical protein NCU07528 [Neurospora crassa OR74A]	317.0	[0..6]	[449..88]

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Predicted Domain #1

Region A:
Residues: [1-264]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTSISKRKNQ QEHIPAEDLE TPKLPKREKI EGTKESNKVR IIILLGYSGY GYHGIQINNP  60
   61 LKTIEGDVVA VLKKLGYLKT NNIDAEHLCI ARAARTDKGV HTLRNLISLN LFVDKPLDIS 120
  121 LLKTELNEAL CSQIRVWSVF PAPKYFNPRI SCESRTYEYL IPSFALLPPK PSCPLFKKMQ 180
  181 KNLSRKLDNE LERNLVYSMN DLISFWNTVK LKQKEIQEMF DTNKDAFTNP FKGMFYEKPI 240
  241 PAGIVIPPQA KLKKALKQAE YYCY

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	62.39794
Match:	2nqpA
Description:	No description for 2nqpA was found.

Predicted functions:

Term	Confidence	Notes
pseudouridine synthase activity	5.19957135839682	bayes_pls_golite062009
intramolecular transferase activity	3.78688422405974	bayes_pls_golite062009
isomerase activity	2.91720316078381	bayes_pls_golite062009
transcription regulator activity	2.31595692797262	bayes_pls_golite062009
catalytic activity	2.02180970970004	bayes_pls_golite062009
binding	1.84674955201903	bayes_pls_golite062009
DNA binding	1.71136719569439	bayes_pls_golite062009
nucleic acid binding	1.59449441921256	bayes_pls_golite062009
RNA binding	0.706879359688019	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [265-451]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNYRIKEDRL KVLQQLLKKY EGRHNFHNFT VTDDSTSPSN YRFIESVTCG TPFVYENWEW  60
   61 IPVTIKGNSF MLNQIRKMMA HVLMIIRSCA PTGLIDKAFD PNITMNISKS PGHVLLLKDI 120
  121 KFSSYNDSVT DGLEKIQFDC FEEDILSLKI KTIYPDIIKL EQKEKLFFSF LSYIDQHTGH 180
  181 QFDYLFG

[Run NCBI BLAST on this sequence.]

Detection Method:	FFAS03
Confidence:	5.12
Match:	2nqpA
Description:	No description for 2nqpA was found.

Predicted functions:

Term	Confidence	Notes
pseudouridine synthase activity	4.5073655253958	bayes_pls_golite062009
intramolecular transferase activity	3.19253766449143	bayes_pls_golite062009
isomerase activity	2.45191348951047	bayes_pls_golite062009
transcription regulator activity	2.32498104079149	bayes_pls_golite062009
binding	1.91512224392568	bayes_pls_golite062009
catalytic activity	1.86133205308688	bayes_pls_golite062009
DNA binding	1.72027738367097	bayes_pls_golite062009
nucleic acid binding	1.61677004803653	bayes_pls_golite062009
RNA binding	0.673531276607007	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions:

Predicted functions: