YRC Public Data Repository - Protein Structure Prediction

Protein:	POT1
Organism:	Homo sapiens
Length:	634 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for POT1.

Description	E-value	Query Range	Subject Range
gi\|114615760 - gi\|114615760\|ref\|XP_519345.2\| PREDICTED: hypothetical protein isoform 3 [Pan troglodytes]	0.0	[1..634]	[1..634]
gi\|7022355, gi\|1... - gi\|7022355\|dbj\|BAA91568.1\| unnamed protein product [Homo sapiens], gi\|13123774\|ref\|NP_056265.1\| prot...	0.0	[1..634]	[1..634]
gi\|55731017 - gi\|55731017\|emb\|CAH92225.1\| hypothetical protein [Pongo abelii] gi\|197100398 - gi\|197100398\|ref\|NP_001127526.1\| POT1 protection of telomeres 1 homolog [Pongo abelii]	0.0	[1..634]	[1..634]
gi\|109068051, gi... - gi\|109068051\|ref\|XP_001087820.1\| PREDICTED: protection of telomeres 1 isoform 2 [Macaca mulatta], gi...	0.0	[1..634]	[1..634]
POTE1_MACFA - Protection of telomeres protein 1 OS=Macaca fascicularis GN=POT1 PE=2 SV=1	0.0	[1..634]	[1..634]
POTE1_MOUSE - Protection of telomeres protein 1 OS=Mus musculus GN=Pot1 PE=1 SV=1	0.0	[1..634]	[1..640]
gi\|73975944 - gi\|73975944\|ref\|XP_851415.1\| PREDICTED: similar to Protection of telomeres 1 (hPot1) (POT1-like telo...	0.0	[1..634]	[302..942]
gi\|109486528 - gi\|109486528\|ref\|XP_001058464.1\| PREDICTED: similar to Protection of telomeres 1 (hPot1) (POT1-like ...	0.0	[4..634]	[328..960]

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Predicted Domain #1

Region A:
Residues: [1-332]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSLVPATNYI YTPLNQLKGG TIVNVYGVVK FFKPPYLSKG TDYCSVVTIV DQTNVKLTCL  60
   61 LFSGNYEALP IIYKNGDIVR FHRLKIQVYK KETQGITSSG FASLTFEGTL GAPIIPRTSS 120
  121 KYFNFTTEDH KMVEALRVWA STHMSPSWTL LKLCDVQPMQ YFDLTCQLLG KAEVDGASFL 180
  181 LKVWDGTRTP FPSWRVLIQD LVLEGDLSHI HRLQNLTIDI LVYDNHVHVA RSLKVGSFLR 240
  241 IYSLHTKLQS MNSENQTMLS LEFHLHGGTS YGRGIRVLPE SNSDVDQLKK DLESANLTAN 300
  301 QHSDVICQSE PDDSFPSSGS VSLYEVERCQ QL

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	124.0
Match:	1xjvA
Description:	Crystal structure of human POT1 bound to telomeric single-stranded DNA (TTAGGGTTAG)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
telomerase inhibitor activity	8.08322438894165	bayes_pls_golite062009
single-stranded telomeric DNA binding	7.13197590913268	bayes_pls_golite062009
telomeric DNA binding	7.07761964836826	bayes_pls_golite062009
DEAD/H-box RNA helicase binding	4.55461999169159	bayes_pls_golite062009
nucleic acid binding	3.99127970564994	bayes_pls_golite062009
DNA binding	3.53568546959418	bayes_pls_golite062009
structure-specific DNA binding	3.53214384646348	bayes_pls_golite062009
single-stranded DNA binding	3.49337353583487	bayes_pls_golite062009
binding	2.83465364476231	bayes_pls_golite062009
structural constituent of ribosome	2.13063800565247	bayes_pls_golite062009
structural molecule activity	1.9177190829469	bayes_pls_golite062009
transcription regulator activity	1.84350127337404	bayes_pls_golite062009
protein binding	1.20309946451799	bayes_pls_golite062009
DNA helicase activity	1.12203697857261	bayes_pls_golite062009
transcription repressor activity	1.11836126147719	bayes_pls_golite062009
transcription activator activity	1.09079153283893	bayes_pls_golite062009
nucleotidyltransferase activity	0.961606389385315	bayes_pls_golite062009
transcription factor activity	0.952569279670437	bayes_pls_golite062009
sequence-specific DNA binding	0.85691075793641	bayes_pls_golite062009
RNA polymerase activity	0.79554655100991	bayes_pls_golite062009
DNA-directed RNA polymerase activity	0.79554655100991	bayes_pls_golite062009
DNA-dependent ATPase activity	0.638831894247026	bayes_pls_golite062009
ribonuclease activity	0.62994126331969	bayes_pls_golite062009
nuclease activity	0.57381531077345	bayes_pls_golite062009
translation regulator activity	0.515576958825022	bayes_pls_golite062009
translation factor activity, nucleic acid binding	0.468402630523277	bayes_pls_golite062009
double-stranded DNA binding	0.378383789953688	bayes_pls_golite062009
exonuclease activity	0.28313884527829	bayes_pls_golite062009
translation initiation factor activity	0.2080607201312	bayes_pls_golite062009
four-way junction helicase activity	0.13147110156029	bayes_pls_golite062009
ATP-dependent DNA helicase activity	0.0179535526984695	bayes_pls_golite062009
helicase activity	0.0121541775159524	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [333-504]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SATILTDHQY LERTPLCAIL KQKAPQQYRI RAKLRSYKPR RLFQSVKLHC PKCHLLQEVP  60
   61 HEGDLDIIFQ DGATKTPDVK LQNTSLYDSK IWTTKNQKGR KVAVHFVKNN GILPLSNECL 120
  121 LLIEGGTLSE ICKLSNKFNS VIPVRSGHED LELLDLSAPF LIQGTIHHYG CK

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #3

Region A:
Residues: [505-634]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QCSSLRSIQN LNSLVDKTSW IPSSVAEALG IVPLQYVFVM TFTLDDGTGV LEAYLMDSDK  60
   61 FFQIPASEVL MDDDLQKSVD MIMDMFCPPG IKIDAYPWLE CFIKSYNVTN GTDNQICYQI 120
  121 FDTTVAEDVI

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

		MCM Score	GO Score	GO Term	SCOP Match	SCOP Description
View	Download	0.516	0.068	nuclear chromosome, telomeric region	d.21.1	Diaminopimelate epimerase-like
View	Download	0.480	N/A	N/A	d.21.1	Diaminopimelate epimerase-like
View	Download	0.420	N/A	N/A	d.21.1	Diaminopimelate epimerase-like
View	Download	0.415	N/A	N/A	d.134.1	Sulfite reductase hemoprotein (SiRHP), domains 2 and 4
View	Download	0.377	N/A	N/A	d.21.1	Diaminopimelate epimerase-like

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: