YRC Public Data Repository - Protein Structure Prediction

Protein:	TIGD6
Organism:	Homo sapiens
Length:	521 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for TIGD6.

Description	E-value	Query Range	Subject Range
gi\|109658526 - gi\|109658526\|gb\|AAI17250.1\| Tigger transposable element derived 6 [Homo sapiens]	0.0	[1..521]	[1..521]
gi\|114602774, gi... - gi\|114602776\|ref\|XP_001164564.1\| PREDICTED: similar to Tigger transposable element derived 6 isoform...	0.0	[1..521]	[1..521]
gi\|66710516, gi\|... - gi\|66710516\|emb\|CAG27692.1\| tigger transposable element derived 14 [Equus caballus], gi\|149726740\|re...	0.0	[1..521]	[1..524]
gi\|57085749 - gi\|57085749\|ref\|XP_546307.1\| PREDICTED: similar to tigger transposable element derived 6 [Canis fami...	0.0	[1..521]	[1..524]
TIGD4_MOUSE - Tigger transposable element-derived protein 4 OS=Mus musculus GN=Tigd4 PE=2 SV=1	0.0	[7..503]	[16..509]
gi\|109075909 - gi\|109075909\|ref\|XP_001085140.1\| PREDICTED: similar to tigger transposable element derived 4 [Macaca...	0.0	[7..507]	[16..512]
gi\|67972064 - gi\|67972064\|dbj\|BAE02374.1\| unnamed protein product [Macaca fascicularis]	0.0	[7..507]	[16..512]

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Predicted Domain #1

Region A:
Residues: [1-138]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MANKGNKKRR QFSLEEKMKV VGAVDSGKRK GDVAKEFGIT PSTLSTFLKD RTKFEEKVRE  60
   61 ASVGPQRKRM RSALYDDIDK AVFAWFQEIH AKNILVTGSV IRKKALNLAN MLGYDNFQAS 120
  121 VGWLNRFRDR HGIALKAV

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	24.39794
Match:	1hlvA
Description:	DNA-binding domain of centromere binding protein B (CENP-B)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
transcription regulator activity	5.13863038737912	bayes_pls_golite062009
DNA binding	4.66369707598026	bayes_pls_golite062009
nucleic acid binding	4.51452285155271	bayes_pls_golite062009
transcription factor activity	4.06706589695599	bayes_pls_golite062009
transcription repressor activity	3.55154985983449	bayes_pls_golite062009
binding	3.02779747447702	bayes_pls_golite062009
sequence-specific DNA binding	2.41271657675151	bayes_pls_golite062009
RNA polymerase II transcription factor activity	2.26183812259792	bayes_pls_golite062009
transcription activator activity	1.77700860354597	bayes_pls_golite062009
transcription corepressor activity	1.49423102874486	bayes_pls_golite062009
transcription factor binding	1.40653841901929	bayes_pls_golite062009
cytoskeletal protein binding	1.24134446233807	bayes_pls_golite062009
specific RNA polymerase II transcription factor activity	1.14886080629275	bayes_pls_golite062009
centromeric DNA binding	1.13545283098583	bayes_pls_golite062009
chromatin binding	1.04132983826241	bayes_pls_golite062009
histone acetyltransferase activity	0.922310816608639	bayes_pls_golite062009
lysine N-acetyltransferase activity	0.922310816608639	bayes_pls_golite062009
transcription cofactor activity	0.84983974758882	bayes_pls_golite062009
protein binding	0.830419844171551	bayes_pls_golite062009
actin binding	0.6102552688489	bayes_pls_golite062009
histone binding	0.557787598121402	bayes_pls_golite062009
RNA binding	0.329588635205335	bayes_pls_golite062009
telomeric DNA binding	0.284650049512347	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	0.141400887946529	bayes_pls_golite062009
protein deacetylase activity	0.13314897698019	bayes_pls_golite062009
histone deacetylase activity	0.0878521297613482	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [139-378]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 CREDSDRLMN GLGIDKINEW HAGEIIKLIA DYSPDDIFNA DETGVFFQLL PQHTLAAKGD  60
   61 HCRGGKKAKQ RLTALFCCNA SGTEKMRPLI VGRSASPHCL KNIHSLPCDY RANQWAWMTR 120
  121 DLFNEWLMQV DARMKRAERR ILLLIDNCSA HNMLPHLERI QVGYLPSNCT AVLQPLNLGI 180
  181 IHTMKVLYQS HLLKQILLKL NSSEDQEEVD IKQAIDMIAA AWWSVKPSTV VKCWQKAGIV 240
  241

[Run NCBI BLAST on this sequence.]

Detection Method:	FFAS03
Confidence:	1.46
Match:	2f7tA
Description:	No description for 2f7tA was found.

Predicted Domain #3

Region A:
Residues: [379-425]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PMEFAECDTE SAASEPDIAI EKLWHTVAIA TCVPNEVNFQ DFVTADD

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #4

Region A:
Residues: [426-521]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DLIISQDTDI IQDMVAGENT SEAGSEDEGE VSLPEQPKVT ITEAISSVQK LRQFLSTCVD  60
   61 IPDAIFGQLN GIDEYLMKRV TQTLIDSKIT DFLQTK

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: