YRC Logo
PROTEIN SEARCH:
Descriptions Names[Advanced Search]

View Structure Prediction Details

Protein: gi|16517172, gi|...
Organism: Homo sapiens
Length: 893 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



[What does the above image mean?]


[Show Ginzu Version Information]


Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|16517172, gi|....

Description E-value Query
Range
Subject
Range
gi|73993195 - gi|73993195|ref|XP_856186.1| PREDICTED: similar to Short transient receptor potential channel 4 (Trp...
0.0 [1..893] [1..893]
gi|16517183, gi|... - gi|16517183|gb|AAL24555.1|AF421364_1 transient receptor potential channel 4 beta splice variant [Rat...
0.0 [1..893] [1..893]
gi|2935630, gi|4... - gi|4200419|gb|AAD10168.1| putative capacitative calcium entry channel Trp4 [Mus musculus], gi|293563...
0.0 [1..893] [1..890]
gi|114649435 - gi|114649435|ref|XP_001148714.1| PREDICTED: transient receptor potential 4 isoform 3 [Pan troglodyte...
gi|6665594, gi|5... - gi|6665594|gb|AAF22929.1|AF063824_1 trp-related protein 4 truncated variant delta [Homo sapiens], gi...
0.0 [1..893] [1..836]
gi|114649429 - gi|114649429|ref|XP_509635.2| PREDICTED: transient receptor potential 4 isoform 5 [Pan troglodytes]
TRPC4 - transient receptor potential cation channel, subfamily C, member 4
gi|168277554 - gi|168277554|dbj|BAG10755.1| short transient receptor potential channel 4 [synthetic construct]
0.0 [1..893] [1..977]

Back

Predicted Domain #1
Region A:
Residues: [1-197]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAQFYYKRNV NAPYRDRIPL RIVRAESELS PSEKAYLNAV EKGDYASVKK SLEEAEIYFK  60
   61 ININCIDPLG RTALLIAIEN ENLELIELLL SFNVYVGDAL LHAIRKEVVG AVELLLNHKK 120
  121 PSGEKQVPPI LLDKQFSEFT PDITPIILAA HTNNYEIIKL LVQKGVSVPR PHEVRCNCVE 180
  181 CVSSSDVDSL RHSRSRL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 29.69897
Match: 1n11A
Description: Ankyrin-R
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
metal ion transmembrane transporter activity 3.06689459321273 bayes_pls_golite062009
ion transmembrane transporter activity 2.89029061890648 bayes_pls_golite062009
cation transmembrane transporter activity 2.66479899929908 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 2.59441577402651 bayes_pls_golite062009
calcium channel activity 2.42383730626707 bayes_pls_golite062009
passive transmembrane transporter activity 2.39688396372487 bayes_pls_golite062009
channel activity 2.39688396372487 bayes_pls_golite062009
cation channel activity 2.37772481426745 bayes_pls_golite062009
ion channel activity 2.36752848265558 bayes_pls_golite062009
substrate-specific channel activity 2.26531840012081 bayes_pls_golite062009
binding 1.98134935593201 bayes_pls_golite062009
gated channel activity 1.75472864911207 bayes_pls_golite062009
structural constituent of muscle 1.64895183402675 bayes_pls_golite062009
protein binding 1.54890102798695 bayes_pls_golite062009
molecular transducer activity 1.50673806965616 bayes_pls_golite062009
signal transducer activity 1.50673806965616 bayes_pls_golite062009
cytoskeletal protein binding 1.27626727482972 bayes_pls_golite062009
transporter activity 1.19000052859754 bayes_pls_golite062009
transmembrane transporter activity 1.02570255606772 bayes_pls_golite062009
receptor activity 0.872395596733881 bayes_pls_golite062009
substrate-specific transporter activity 0.835937200249181 bayes_pls_golite062009
transmembrane receptor activity 0.684449236640306 bayes_pls_golite062009
mechanically-gated ion channel activity 0.645199153849127 bayes_pls_golite062009
mechanically gated channel activity 0.645199153849127 bayes_pls_golite062009
structural constituent of cytoskeleton 0.360134283189251 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [198-260]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NIYKALASPS LIALSSEDPF LTAFQLSWEL QELSKVENEF KSEYEELSRQ CKQFAKDLLD  60
   61 QTR

[Run NCBI BLAST on this sequence.]

Detection Method: Pfam
Confidence: 29.537602
Match: PF08344.2
Description: No description for PF08344.2 was found.

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [261-340]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SSRELEIILN YRDDNSLIEE QSGNDLARLK LAIKYRQKEF VAQPNCQQLL ASRWYDEFPG  60
   61 WRRRHWAVKM VTCFIIGLLF 

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [341-648]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PVFSVCYLIA PKSPLGLFIR KPFIKFICHT ASYLTFLFLL LLASQHIDRS DLNRQGPPPT  60
   61 IVEWMILPWV LGFIWGEIKQ MWDGGLQDYI HDWWNLMDFV MNSLYLATIS LKIVAFVKYS 120
  121 ALNPRESWDM WHPTLVAEAL FAIANIFSSL RLISLFTANS HLGPLQISLG RMLLDILKFL 180
  181 FIYCLVLLAF ANGLNQLYFY YEETKGLTCK GIRCEKQNNA FSTLFETLQS LFWSIFGLIN 240
  241 LYVTNVKAQH EFTEFVGATM FGTYNVISLV VLLNMLIAMM NNSYQLIADH ADIEWKFART 300
  301 KLWMSYFE

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 28.69897
Match: 2a79B
Description: Mammalian Shaker Kv1.2 potassium channel- beta subunit complex
Matching Structure (courtesy of the PDB):

Predicted Domain #5
Region A:
Residues: [649-759]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EGGTLPTPFN VIPSPKSLWY LIKWIWTHLC KKKMRRKPES FGTIGRRAAD NLRRHHQYQE  60
   61 VMRNLVKRYV AAMIRDAKTE EGLTEENFKE LKQDISSFRF EVLGLLRGSK L

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #6
Region A:
Residues: [760-893]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 STIQSANASK ESSNSADSDE KSDSEEEVAR QQAAGPLERN IQLESRGLAS RGDLSIPGLS  60
   61 EQCVLVDHRE RNTDTLGLQV GKRVCPFKSE KVVVEDTVPI IPKEKHAKEE DSSIDYDLNL 120
  121 PDTVTHEDYV TTRL

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle