YRC Public Data Repository - Protein Structure Prediction

Protein:	CD81
Organism:	Homo sapiens
Length:	236 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for CD81.

Description	E-value	Query Range	Subject Range
CD81_SAGOE - CD81 protein OS=Saguinus oedipus GN=CD81 PE=2 SV=1	4.0E-53	[1..236]	[1..236]
gi\|61366274, gi\|... - gi\|61366274\|gb\|AAX42838.1\| CD81 antigen [synthetic construct], gi\|54695882\|gb\|AAV38313.1\| CD81 antig...	9.0E-53	[1..236]	[1..236]
gi\|109104994 - gi\|109104994\|ref\|XP_001093228.1\| PREDICTED: CD81 molecule [Macaca mulatta] CD81_CHLAE - CD81 antigen OS=Chlorocebus aethiops GN=CD81 PE=2 SV=1	1.0E-52	[1..236]	[1..236]
CD81_BOVIN - CD81 antigen OS=Bos taurus GN=CD81 PE=2 SV=1	2.0E-52	[1..236]	[1..236]
CD81_RAT - CD81 antigen OS=Rattus norvegicus GN=Cd81 PE=1 SV=1	1.0E-51	[1..236]	[1..236]
gi\|33286240 - gi\|33286240\|gb\|AAQ01667.1\| CD81 antigen [Tupaia belangeri chinensis]	2.0E-51	[1..236]	[1..236]
gi\|55250474 - gb\|AAH85998.1\| Unknown (protein for MGC:98020) [Xenopus laevis] CD81_MOUSE - CD81 antigen OS=Mus musculus GN=Cd81 PE=1 SV=2 gi\|117616294 - gi\|117616294\|gb\|ABK42165.1\| CD81 [synthetic construct]	2.0E-51	[1..236]	[1..236]
gi\|115522021, gi... - gi\|118403822\|ref\|NP_001072147.1\| CD81 antigen [Sus scrofa], gi\|115522021\|gb\|ABJ09400.1\| CD81 antigen...	6.0E-51	[1..236]	[1..236]

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Predicted Domain #1

Region A:
Residues: [1-110]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGVEGCTKCI KYLLFVFNFV FWLAGGVILG VALWLRHDPQ TTNLLYLELG DKPAPNTFYV  60
   61 GIYILIAVGA VMMFVGFLGC YGAIQESQCL LGTFFTCLVI LFACEVAAGI

[Run NCBI BLAST on this sequence.]

Detection Method:	FFAS03
Confidence:	1.1
Match:	1oedC
Description:	Acetylcholine receptor protein, delta chain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
nicotinic acetylcholine-activated cation-selective channel activity	8.09774750177444	bayes_pls_golite062009
extracellular ligand-gated ion channel activity	6.8138989067086	bayes_pls_golite062009
excitatory extracellular ligand-gated ion channel activity	6.8138989067086	bayes_pls_golite062009
acetylcholine binding	6.04235159077861	bayes_pls_golite062009
gated channel activity	5.66609833149359	bayes_pls_golite062009
ligand-gated channel activity	5.65359564397775	bayes_pls_golite062009
ligand-gated ion channel activity	5.65359564397775	bayes_pls_golite062009
ion channel activity	5.59877286813906	bayes_pls_golite062009
cation channel activity	5.49725615782424	bayes_pls_golite062009
acetylcholine receptor activity	5.40168515414817	bayes_pls_golite062009
passive transmembrane transporter activity	4.88852337948775	bayes_pls_golite062009
channel activity	4.88852337948775	bayes_pls_golite062009
substrate-specific channel activity	4.75987274214331	bayes_pls_golite062009
metal ion transmembrane transporter activity	4.43671572548228	bayes_pls_golite062009
transporter activity	4.33216679738402	bayes_pls_golite062009
transmembrane transporter activity	4.2745563261123	bayes_pls_golite062009
amine binding	4.25140819530684	bayes_pls_golite062009
substrate-specific transporter activity	4.19026880603966	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	4.14475572252231	bayes_pls_golite062009
transmembrane receptor activity	4.13892843658445	bayes_pls_golite062009
ion transmembrane transporter activity	4.11908493779954	bayes_pls_golite062009
receptor activity	3.9625821847327	bayes_pls_golite062009
cation transmembrane transporter activity	3.94631845574808	bayes_pls_golite062009
molecular transducer activity	3.87903570844696	bayes_pls_golite062009
signal transducer activity	3.87903570844696	bayes_pls_golite062009
chloride channel regulator activity	3.80555448212147	bayes_pls_golite062009
neurotransmitter binding	3.68173030115209	bayes_pls_golite062009
neurotransmitter receptor activity	3.59464831713762	bayes_pls_golite062009
toxin binding	2.56943469551261	bayes_pls_golite062009
binding	2.40028520341187	bayes_pls_golite062009
protein binding	1.46482989994288	bayes_pls_golite062009
drug binding	0.721991254175078	bayes_pls_golite062009
serotonin binding	0.707250780695203	bayes_pls_golite062009
serotonin-activated cation-selective channel activity	0.684758689525935	bayes_pls_golite062009
G-protein coupled receptor activity	0.35204430646141	bayes_pls_golite062009
kinase binding	0.292964438799031	bayes_pls_golite062009
	0.269193639162997	bayes_pls_golite062009
protein kinase binding	0.267267173186573	bayes_pls_golite062009
channel regulator activity	0.252055844136184	bayes_pls_golite062009
adenylate cyclase binding	0.109562749490086	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [111-236]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 WGFVNKDQIA KDVKQFYDQA LQQAVVDDDA NNAKAVVKTF HETLDCCGSS TLTALTTSVL  60
   61 KNNLCPSGSN IISNLFKEDC HQKIDDLFSG KLYLIGIAAI VVAVIMIFEM ILSMVLCCGI 120
  121 RNSSVY

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	11.69897
Match:	1g8qA
Description:	CD81 extracellular domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
protein binding	1.71804056581958	bayes_pls_golite062009
binding	1.62531598262239	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions:

Predicted functions: