YRC Public Data Repository - Protein Structure Prediction

Protein:	GATA3
Organism:	Homo sapiens
Length:	443 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for GATA3.

Description	E-value	Query Range	Subject Range
gi\|61372534, gi\|... - gi\|61372538\|gb\|AAX43862.1\| GATA binding protein 3 [synthetic construct], gi\|61372534\|gb\|AAX43861.1\| ...	3.0E-58	[1..443]	[1..443]
gi\|31662 - gi\|31662\|emb\|CAA38877.1\| GATA-3 [Homo sapiens]	5.0E-58	[1..443]	[1..443]
gi\|109088183, gi... - gi\|109088183\|ref\|XP_001108337.1\| PREDICTED: similar to GATA binding protein 3 isoform 1 isoform 3 [M...	2.0E-57	[1..443]	[1..444]
gi\|55633439, gi\|... - gi\|55633439\|ref\|XP_507651.1\| PREDICTED: GATA binding protein 3 isoform 3 [Pan troglodytes], gi\|11462...	4.0E-57	[1..443]	[1..444]
gi\|18959228, gi\|... - gi\|18959228\|ref\|NP_579827.1\| GATA binding protein 3 [Rattus norvegicus], gi\|149021023\|gb\|EDL78630.1\|...	4.0E-56	[1..443]	[1..444]
GATA3_BOVIN - Trans-acting T-cell-specific transcription factor GATA-3 OS=Bos taurus GN=GATA3 PE=2 SV=1	6.0E-56	[1..443]	[1..443]
gi\|74207086 - gi\|74207086\|dbj\|BAE33319.1\| unnamed protein product [Mus musculus]	3.0E-55	[1..443]	[1..442]

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Predicted Domain #1

Region A:
Residues: [1-259]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEVTADQPRW VSHHHPAVLN GQHPDTHHPG LSHSYMDAAQ YPLPEEVDVL FNIDGQGNHV  60
   61 PPYYGNSVRA TVQRYPPTHH GSQVCRPPLL HGSLPWLDGG KALGSHHTAS PWNLSPFSKT 120
  121 SIHHGSPGPL SVYPPASSSS LSGGHASPHL FTFPPTPPKD VSPDPSLSTP GSAGSARQDE 180
  181 KECLKYQVPL PDSMKLESSH SRGSMTALGG ASSSTHHPIT TYPPYVPEYS SGLFPPSSLL 240
  241 GGSPTGFGCK SRPKARSST

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2

Region A:
Residues: [260-324]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GRECVNCGAT STPLWRRDGT GHYLCNACGL YHKMNGQNRP LIKPKRRLSA ARRAGTSCAN  60
   61 CQTTT

[Run NCBI BLAST on this sequence.]

Detection Method:	FFAS03
Confidence:	2.85
Match:	2gatA
Description:	Erythroid transcription factor GATA-1
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
transcription regulator activity	3.84932768708444	bayes_pls_golite062009
DNA binding	3.45124926204188	bayes_pls_golite062009
nucleic acid binding	3.34875987514951	bayes_pls_golite062009
binding	2.8684204787273	bayes_pls_golite062009
transcription activator activity	2.7888666510808	bayes_pls_golite062009
transcription factor activity	2.74592237402384	bayes_pls_golite062009
sequence-specific DNA binding	2.5486735958299	bayes_pls_golite062009
protein binding	2.35367391992524	bayes_pls_golite062009
RNA polymerase II transcription factor activity	2.23212813739998	bayes_pls_golite062009
transcription factor binding	1.22761682002	bayes_pls_golite062009
ligand-dependent nuclear receptor activity	1.1269808729848	bayes_pls_golite062009
specific RNA polymerase II transcription factor activity	1.02819346233483	bayes_pls_golite062009
general RNA polymerase II transcription factor activity	0.551724917261005	bayes_pls_golite062009
transcription cofactor activity	0.449959641856445	bayes_pls_golite062009
transcription repressor activity	0.199267983374872	bayes_pls_golite062009
catalytic activity	0.133319360419662	bayes_pls_golite062009

Predicted Domain #3

Region A:
Residues: [325-443]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TTLWRRNANG DPVCNACGLY YKLHNINRPL TMKKEGIQTR NRKMSSKSKK CKKVHDSLED  60
   61 FPKNSSFNPA ALSRHMSSLS HISPFSHSSH MLTTPTPMHP PSSLSFGPHH PSSMVTAMG

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	15.30103
Match:	2gatA
Description:	Erythroid transcription factor GATA-1
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
transcription regulator activity	4.00967542385368	bayes_pls_golite062009
DNA binding	3.60745514727532	bayes_pls_golite062009
nucleic acid binding	3.47256374293954	bayes_pls_golite062009
binding	2.96409924710655	bayes_pls_golite062009
transcription activator activity	2.9532663930699	bayes_pls_golite062009
transcription factor activity	2.90769972671972	bayes_pls_golite062009
sequence-specific DNA binding	2.72967350701574	bayes_pls_golite062009
protein binding	2.44501340584871	bayes_pls_golite062009
RNA polymerase II transcription factor activity	2.40923942043513	bayes_pls_golite062009
ligand-dependent nuclear receptor activity	1.49515149729803	bayes_pls_golite062009
transcription factor binding	1.38523780690867	bayes_pls_golite062009
specific RNA polymerase II transcription factor activity	1.26452462867497	bayes_pls_golite062009
general RNA polymerase II transcription factor activity	0.68943696300126	bayes_pls_golite062009
transcription cofactor activity	0.58115018700114	bayes_pls_golite062009
transcription repressor activity	0.256420113528322	bayes_pls_golite062009
catalytic activity	0.101795606736461	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions:

Predicted functions: