Protein Overview: GATA3

General Information:
Name(s) found:	GATA3 [HGNC (HUGO)]
Description(s) found: Found 37 descriptions. SHOW ALL	GATA binding protein 3 [HGNC (HUGO)]
Organism:	Homo sapiens
Length:	443 amino acids
Gene Ontology:
Cellular Component:	NONE FOUND
Biological Process:	NONE FOUND
Molecular Function:	NONE FOUND

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEVTADQPRW VSHHHPAVLN GQHPDTHHPG LSHSYMDAAQ YPLPEEVDVL FNIDGQGNHV  60
   61 PPYYGNSVRA TVQRYPPTHH GSQVCRPPLL HGSLPWLDGG KALGSHHTAS PWNLSPFSKT 120
  121 SIHHGSPGPL SVYPPASSSS LSGGHASPHL FTFPPTPPKD VSPDPSLSTP GSAGSARQDE 180
  181 KECLKYQVPL PDSMKLESSH SRGSMTALGG ASSSTHHPIT TYPPYVPEYS SGLFPPSSLL 240
  241 GGSPTGFGCK SRPKARSSTG RECVNCGATS TPLWRRDGTG HYLCNACGLY HKMNGQNRPL 300
  301 IKPKRRLSAA RRAGTSCANC QTTTTTLWRR NANGDPVCNA CGLYYKLHNI NRPLTMKKEG 360
  361 IQTRNRKMSS KSKKCKKVHD SLEDFPKNSS FNPAALSRHM SSLSHISPFS HSSHMLTTPT 420
  421 PMHPPSSLSF GPHHPSSMVT AMG

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Microscopy / Localization Data

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No microscopy data found in the PDR for this protein.

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..259]	MSA	2.190997	View MSA. No confident structure predictions are available.
2	View Details	[260..324]	FFAS03	2.85	Erythroid transcription factor GATA-1
3	View Details	[325..443]	PSI-BLAST	15.30103	Erythroid transcription factor GATA-1

Functions predicted (by domain):

#

Gene Ontology predictions

1

No functions predicted.

2

Term	Confidence	Notes
transcription regulator activity	3.84932768708444	bayes_pls_golite062009
DNA binding	3.45124926204188	bayes_pls_golite062009
nucleic acid binding	3.34875987514951	bayes_pls_golite062009
binding	2.8684204787273	bayes_pls_golite062009
transcription activator activity	2.7888666510808	bayes_pls_golite062009
transcription factor activity	2.74592237402384	bayes_pls_golite062009
sequence-specific DNA binding	2.5486735958299	bayes_pls_golite062009
protein binding	2.35367391992524	bayes_pls_golite062009
RNA polymerase II transcription factor activity	2.23212813739998	bayes_pls_golite062009
transcription factor binding	1.22761682002	bayes_pls_golite062009
ligand-dependent nuclear receptor activity	1.1269808729848	bayes_pls_golite062009
specific RNA polymerase II transcription factor activity	1.02819346233483	bayes_pls_golite062009
general RNA polymerase II transcription factor activity	0.551724917261005	bayes_pls_golite062009
transcription cofactor activity	0.449959641856445	bayes_pls_golite062009
transcription repressor activity	0.199267983374872	bayes_pls_golite062009
catalytic activity	0.133319360419662	bayes_pls_golite062009

3

Term	Confidence	Notes
transcription regulator activity	4.00967542385368	bayes_pls_golite062009
DNA binding	3.60745514727532	bayes_pls_golite062009
nucleic acid binding	3.47256374293954	bayes_pls_golite062009
binding	2.96409924710655	bayes_pls_golite062009
transcription activator activity	2.9532663930699	bayes_pls_golite062009
transcription factor activity	2.90769972671972	bayes_pls_golite062009
sequence-specific DNA binding	2.72967350701574	bayes_pls_golite062009
protein binding	2.44501340584871	bayes_pls_golite062009
RNA polymerase II transcription factor activity	2.40923942043513	bayes_pls_golite062009
ligand-dependent nuclear receptor activity	1.49515149729803	bayes_pls_golite062009
transcription factor binding	1.38523780690867	bayes_pls_golite062009
specific RNA polymerase II transcription factor activity	1.26452462867497	bayes_pls_golite062009
general RNA polymerase II transcription factor activity	0.68943696300126	bayes_pls_golite062009
transcription cofactor activity	0.58115018700114	bayes_pls_golite062009
transcription repressor activity	0.256420113528322	bayes_pls_golite062009
catalytic activity	0.101795606736461	bayes_pls_golite062009

Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.97

Source: Reynolds et al. (2008)

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle