YRC Logo
PROTEIN SEARCH:
Descriptions Names[Advanced Search]

View Structure Prediction Details

Protein: GATA3
Organism: Homo sapiens
Length: 443 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



[What does the above image mean?]


[Show Ginzu Version Information]


Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for GATA3.

Description E-value Query
Range		 Subject
Range
gi|61372534, gi|... - gi|61372538|gb|AAX43862.1| GATA binding protein 3 [synthetic construct], gi|61372534|gb|AAX43861.1| ...
 3.0E-58 [1..443] [1..443]
gi|31662 - gi|31662|emb|CAA38877.1| GATA-3 [Homo sapiens]
 5.0E-58 [1..443] [1..443]
gi|109088183, gi... - gi|109088183|ref|XP_001108337.1| PREDICTED: similar to GATA binding protein 3 isoform 1 isoform 3 [M...
 2.0E-57 [1..443] [1..444]
gi|55633439, gi|... - gi|55633439|ref|XP_507651.1| PREDICTED: GATA binding protein 3 isoform 3 [Pan troglodytes], gi|11462...
 4.0E-57 [1..443] [1..444]
gi|18959228, gi|... - gi|18959228|ref|NP_579827.1| GATA binding protein 3 [Rattus norvegicus], gi|149021023|gb|EDL78630.1|...
 4.0E-56 [1..443] [1..444]
GATA3_BOVIN - Trans-acting T-cell-specific transcription factor GATA-3 OS=Bos taurus GN=GATA3 PE=2 SV=1
 6.0E-56 [1..443] [1..443]
gi|74207086 - gi|74207086|dbj|BAE33319.1| unnamed protein product [Mus musculus]
 3.0E-55 [1..443] [1..442]

Back

Predicted Domain #1
Region A:
Residues: [1-259] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEVTADQPRW VSHHHPAVLN GQHPDTHHPG LSHSYMDAAQ YPLPEEVDVL FNIDGQGNHV  60
   61 PPYYGNSVRA TVQRYPPTHH GSQVCRPPLL HGSLPWLDGG KALGSHHTAS PWNLSPFSKT 120
  121 SIHHGSPGPL SVYPPASSSS LSGGHASPHL FTFPPTPPKD VSPDPSLSTP GSAGSARQDE 180
  181 KECLKYQVPL PDSMKLESSH SRGSMTALGG ASSSTHHPIT TYPPYVPEYS SGLFPPSSLL 240
  241 GGSPTGFGCK SRPKARSST

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [260-324] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GRECVNCGAT STPLWRRDGT GHYLCNACGL YHKMNGQNRP LIKPKRRLSA ARRAGTSCAN  60
   61 CQTTT

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 2.85
Match: 2gatA
Description: Erythroid transcription factor GATA-1
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 3.84932768708444 bayes_pls_golite062009
DNA binding 3.45124926204188 bayes_pls_golite062009
nucleic acid binding 3.34875987514951 bayes_pls_golite062009
binding 2.8684204787273 bayes_pls_golite062009
transcription activator activity 2.7888666510808 bayes_pls_golite062009
transcription factor activity 2.74592237402384 bayes_pls_golite062009
sequence-specific DNA binding 2.5486735958299 bayes_pls_golite062009
protein binding 2.35367391992524 bayes_pls_golite062009
RNA polymerase II transcription factor activity 2.23212813739998 bayes_pls_golite062009
transcription factor binding 1.22761682002 bayes_pls_golite062009
ligand-dependent nuclear receptor activity 1.1269808729848 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 1.02819346233483 bayes_pls_golite062009
general RNA polymerase II transcription factor activity 0.551724917261005 bayes_pls_golite062009
transcription cofactor activity 0.449959641856445 bayes_pls_golite062009
transcription repressor activity 0.199267983374872 bayes_pls_golite062009
catalytic activity 0.133319360419662 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [325-443] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TTLWRRNANG DPVCNACGLY YKLHNINRPL TMKKEGIQTR NRKMSSKSKK CKKVHDSLED  60
   61 FPKNSSFNPA ALSRHMSSLS HISPFSHSSH MLTTPTPMHP PSSLSFGPHH PSSMVTAMG

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 15.30103
Match: 2gatA
Description: Erythroid transcription factor GATA-1
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 4.00967542385368 bayes_pls_golite062009
DNA binding 3.60745514727532 bayes_pls_golite062009
nucleic acid binding 3.47256374293954 bayes_pls_golite062009
binding 2.96409924710655 bayes_pls_golite062009
transcription activator activity 2.9532663930699 bayes_pls_golite062009
transcription factor activity 2.90769972671972 bayes_pls_golite062009
sequence-specific DNA binding 2.72967350701574 bayes_pls_golite062009
protein binding 2.44501340584871 bayes_pls_golite062009
RNA polymerase II transcription factor activity 2.40923942043513 bayes_pls_golite062009
ligand-dependent nuclear receptor activity 1.49515149729803 bayes_pls_golite062009
transcription factor binding 1.38523780690867 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 1.26452462867497 bayes_pls_golite062009
general RNA polymerase II transcription factor activity 0.68943696300126 bayes_pls_golite062009
transcription cofactor activity 0.58115018700114 bayes_pls_golite062009
transcription repressor activity 0.256420113528322 bayes_pls_golite062009
catalytic activity 0.101795606736461 bayes_pls_golite062009
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle