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View Structure Prediction Details

Protein: PSMC3
Organism: Homo sapiens
Length: 439 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PSMC3.

Description E-value Query
Range
Subject
Range
gi|114637619 - gi|114637619|ref|XP_508413.2| PREDICTED: proteasome 26S ATPase subunit 3 [Pan troglodytes]
2.0E-88 [1..439] [117..555]
gi|74185161 - gi|74185161|dbj|BAE39181.1| unnamed protein product [Mus musculus]
4.0E-88 [1..439] [64..502]
gi|88950711, gi|... - gi|88950711|ref|ZP_01153285.1| AAA ATPase, CDC48 [Methanosaeta thermophila PT], gi|88929910|gb|EAR48...
2.0E-87 [2..438] [296..717]
gi|33870816 - gi|33870816|gb|AAH08713.2| PSMC3 protein [Homo sapiens]
3.0E-87 [1..439] [53..491]
Y1297_ARCFU - Cell division cycle protein 48 homolog AF_1297 OS=Archaeoglobus fulgidus (strain ATCC 49558 / VC-16 ...
Y1297_ARCFU, YC9... - (O28972) Cell division cycle protein 48 homolog AF1297, Cell division cycle protein 48 homolog AF_12...
4.0E-87 [2..438] [286..721]
gi|119524342, gi... - gi|119719222|ref|YP_919717.1| AAA family ATPase, CDC48 subfamily protein [Thermofilum pendens Hrk 5]...
1.0E-86 [3..438] [288..709]
gi|110620803, gi... - gi|147920787|ref|YP_685407.1| cell division cycle protein 48 [uncultured methanogenic archaeon RC-I]...
5.0E-86 [2..438] [296..717]
gi|76636495 - gi|76636495|ref|XP_585224.2| PREDICTED: similar to 26S protease regulatory subunit 6A (TAT-binding p...
8.0E-86 [1..403] [64..466]

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Predicted Domain #1
Region A:
Residues: [1-439]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNLLPNIESP VTRQEKMATV WDEAEQDGIG EEVLKMSTEE IIQRTRLLDS EIKIMKSEVL  60
   61 RVTHELQAMK DKIKENSEKI KVNKTLPYLV SNVIELLDVD PNDQEEDGAN IDLDSQRKGK 120
  121 CAVIKTSTRQ TYFLPVIGLV DAEKLKPGDL VGVNKDSYLI LETLPTEYDS RVKAMEVDER 180
  181 PTEQYSDIGG LDKQIQELVE AIVLPMNHKE KFENLGIQPP KGVLMYGPPG TGKTLLARAC 240
  241 AAQTKATFLK LAGPQLVQMF IGDGAKLVRD AFALAKEKAP SIIFIDELDA IGTKRFDSEK 300
  301 AGDREVQRTM LELLNQLDGF QPNTQVKVIA ATNRVDILDP ALLRSGRLDR KIEFPMPNEE 360
  361 ARARIMQIHS RKMNVSPDVN YEELARCTDD FNGAQCKAVC VEAGMIALRR GATELTHEDY 420
  421 MEGILEVQAK KKANLQYYA

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 80.522879
Match: 1oz4A
Description: VCP/p97
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
hydrolase activity 4.71605970197038 bayes_pls_golite062009
peptidase activity 3.6994352506738 bayes_pls_golite062009
peptidase activity, acting on L-amino acid peptides 3.52737232558306 bayes_pls_golite062009
endopeptidase activity 3.48761031707503 bayes_pls_golite062009
binding 2.44689197844883 bayes_pls_golite062009
motor activity 2.32425703346903 bayes_pls_golite062009
microtubule motor activity 2.26003723459523 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides 1.85030653553169 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 1.84811666933472 bayes_pls_golite062009
catalytic activity 1.00104173493322 bayes_pls_golite062009
nucleic acid binding 0.901460716954519 bayes_pls_golite062009
purine nucleotide binding 0.569910969126728 bayes_pls_golite062009
purine ribonucleotide binding 0.568840867400671 bayes_pls_golite062009
ribonucleotide binding 0.568779924702229 bayes_pls_golite062009
nucleotide binding 0.564275755355315 bayes_pls_golite062009
pyrophosphatase activity 0.540750418412449 bayes_pls_golite062009
nucleoside-triphosphatase activity 0.517457589081898 bayes_pls_golite062009
DNA binding 0.341209040153805 bayes_pls_golite062009
cytoskeletal protein binding 0.205488803771958 bayes_pls_golite062009
ATP binding 0.1860481660648 bayes_pls_golite062009
adenyl ribonucleotide binding 0.152859582615242 bayes_pls_golite062009
adenyl nucleotide binding 0.138615225841109 bayes_pls_golite062009
protein binding 0.071010918255742 bayes_pls_golite062009
transcription regulator activity 0.050107780790998 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle