YRC Public Data Repository - Protein Structure Prediction

Protein:	SF3A3
Organism:	Homo sapiens
Length:	501 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SF3A3.

Description	E-value	Query Range	Subject Range
gi\|54311245, gi\|... - gi\|54311245\|gb\|AAH84823.1\| LOC495359 protein [Xenopus laevis], gi\|148227146\|ref\|NP_001088491.1\| hypo...	0.0	[1..501]	[1..501]
gi\|551450 - gi\|551450\|emb\|CAA57388.1\| splicing factor SF3a60 [Homo sapiens]	0.0	[1..501]	[1..501]
gi\|68533853, gi\|... - gi\|71043736\|ref\|NP_001020869.1\| splicing factor 3a, subunit 3 [Rattus norvegicus], gi\|68533853\|gb\|AA... tr\|G3HE04\|G3HE04... - Splicing factor 3A subunit 3 OS=Cricetulus griseus GN=I79_008773 PE=4 SV=1 SF3A3_MOUSE - Splicing factor 3A subunit 3 OS=Mus musculus GN=Sf3a3 PE=1 SV=2	0.0	[1..501]	[1..501]
gi\|74356387, gi\|... - gi\|77736043\|ref\|NP_001029720.1\| splicing factor 3a, subunit 3, 60kDa [Bos taurus], gi\|74356387\|gb\|AA...	0.0	[1..501]	[1..501]
gi\|149694655 - gi\|149694655\|ref\|XP_001503602.1\| PREDICTED: similar to Splicing factor 3a, subunit 3, 60kDa [Equus c... gi\|73976918, gi\|... - gi\|73976918\|ref\|XP_532553.2\| PREDICTED: similar to Splicing factor 3A subunit 3 (Spliceosome associa...	0.0	[1..501]	[1..501]
gi\|62859201 - gi\|62859201\|ref\|NP_001017118.1\| hypothetical protein LOC549872 [Xenopus (Silurana) tropicalis]	0.0	[1..501]	[1..501]
gi\|50759732, gi\|... - gi\|60099133\|emb\|CAH65397.1\| hypothetical protein [Gallus gallus], ref\|XP_417755.1\| PREDICTED: simila...	0.0	[1..501]	[1..501]
gi\|51972162, gi\|... - gi\|51972162\|ref\|NP_001004289.1\| splicing factor 3a, subunit 3 [Danio rerio], gi\|49618981\|gb\|AAT68075...	0.0	[1..501]	[1..501]

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Predicted Domain #1

Region A:
Residues: [1-219]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 METILEQQRR YHEEKERLMD VMAKEMLTKK STLRDQINSD HRTRAMQDRY MEVSGNLRDL  60
   61 YDDKDGLRKE ELNAISGPNE FAEFYNRLKQ IKEFHRKHPN EICVPMSVEF EELLKARENP 120
  121 SEEAQNLVEF TDEEGYGRYL DLHDCYLKYI NLKASEKLDY ITYLSIFDQL FDIPKERKNA 180
  181 EYKRYLEMLL EYLQDYTDRV KPLQDQNELF GKIQAEFEK

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2

Region A:
Residues: [220-294]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KWENGTFPGW PKETSSALTH AGAHLDLSAF SSWEELASLG LDRLKSALLA LGLKCGGTLE  60
   61 ERAQRLFSTK GKSLE

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3

Region A:
Residues: [295-376]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SLDTSLFAKN PKSKGTKRDT ERNKDIAFLE AQIYEYVEIL GEQRHLTHEN VQRKQARTGE  60
   61 EREEEEEEQI SESESEDEEN EI

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4

Region A:
Residues: [377-501]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IYNPKNLPLG WDGKPIPYWL YKLHGLNINY NCEICGNYTY RGPKAFQRHF AEWRHAHGMR  60
   61 CLGIPNTAHF ANVTQIEDAV SLWAKLKLQK ASERWQPDTE EEYEDSSGNV VNKKTYEDLK 120
  121 RQGLL

[Run NCBI BLAST on this sequence.]

Detection Method:	FFAS03
Confidence:	1.05
Match:	1zr9A
Description:	Solution Structure of a Human C2H2-type Zinc Finger Protein
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
transcription regulator activity	3.37529385176635	bayes_pls_golite062009
DNA binding	3.3049326844117	bayes_pls_golite062009
nucleic acid binding	3.24981360535232	bayes_pls_golite062009
snRNA binding	3.16782731106334	bayes_pls_golite062009
RNA binding	3.11293528368816	bayes_pls_golite062009
binding	2.99742524370422	bayes_pls_golite062009
U1 snRNA binding	2.86343975521155	bayes_pls_golite062009
transcription factor activity	2.44389510173662	bayes_pls_golite062009
RNA polymerase II transcription factor activity	1.57041104288348	bayes_pls_golite062009
mRNA binding	1.28525296322454	bayes_pls_golite062009
transcription activator activity	1.20323819132961	bayes_pls_golite062009
protein binding	0.952480850696098	bayes_pls_golite062009
sequence-specific DNA binding	0.732558534458316	bayes_pls_golite062009
transcription repressor activity	0.686318575498149	bayes_pls_golite062009
chromatin binding	0.626365497850853	bayes_pls_golite062009
transcription factor binding	0.515821187939278	bayes_pls_golite062009
cytoskeletal protein binding	0.380243728411498	bayes_pls_golite062009
catalytic activity	0.263007611601737	bayes_pls_golite062009
specific RNA polymerase II transcription factor activity	0.200483461579207	bayes_pls_golite062009
tubulin binding	0.151955152284472	bayes_pls_golite062009
transcription cofactor activity	0.113925660147477	bayes_pls_golite062009
structure-specific DNA binding	0.0855506955761403	bayes_pls_golite062009
microtubule binding	0.05082413668213	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: