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View Structure Prediction Details

Protein: GDB1
Organism: Saccharomyces cerevisiae
Length: 1536 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for GDB1.

Description E-value Query
Range
Subject
Range
GDB1 - Glycogen debranching enzyme containing glucanotranferase and alpha-1,6-amyloglucosidase activities, ...
GDE_YEAST - Glycogen debranching enzyme OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=GDB1 PE=1 SV...
0.0 [1..1536] [1..1536]
AGL - amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase
0.0 [52..1528] [36..1532]
CG9485-PC - This gene is referred to in FlyBase by the symbol Dmel\CG9485 (CG9485, FBgn0034618). It is a protein...
0.0 [53..1534] [44..1544]
GDE_RABIT - Glycogen debranching enzyme OS=Oryctolagus cuniculus GN=AGL PE=1 SV=1
0.0 [52..1528] [59..1555]
gi|85112718 - gi|85112718|ref|XP_964396.1| hypothetical protein [Neurospora crassa OR74A]
gi|32408885, gi|... - gi|32408885|ref|XP_324923.1| hypothetical protein [Neurospora crassa], gi|28926176|gb|EAA35160.1| hy...
0.0 [2..1527] [9..1514]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
0.0 [52..1528] [19..1515]

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Predicted Domain #1
Region A:
Residues: [1-110]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNRSLLLRLS DTGEPITSCS YGKGVLTLPP IPLPKDAPKD QPLYTVKLLV SAGSPVARDG  60
   61 LVWTNCPPDH NTPFKRDKFY KKIIHSSFHE DDCIDLNVYA PGSYCFYLSF 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 87.522879
Match: 1j0hA_
Description: Neopullulanase, central domain; Neopullulanase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
hydrolase activity, hydrolyzing O-glycosyl compounds 4.55801959095491 bayes_pls_golite062009
hydrolase activity, acting on glycosyl bonds 4.29108420555514 bayes_pls_golite062009
hydrolase activity 3.3484406095165 bayes_pls_golite062009
glucosidase activity 1.92306554001182 bayes_pls_golite062009
catalytic activity 1.85569074294201 bayes_pls_golite062009
cation transmembrane transporter activity 1.69105818607475 bayes_pls_golite062009
alpha-amylase activity 1.42264105957213 bayes_pls_golite062009
ion transmembrane transporter activity 1.39709424453076 bayes_pls_golite062009
amylase activity 1.37652764526134 bayes_pls_golite062009
ligand-gated ion channel activity 1.05409109078129 bayes_pls_golite062009
ligand-gated channel activity 1.05409109078129 bayes_pls_golite062009
cation channel activity 1.05200514582216 bayes_pls_golite062009
gated channel activity 0.9985637228196 bayes_pls_golite062009
phosphorylase activity 0.99159540154441 bayes_pls_golite062009
ion channel activity 0.90214915215542 bayes_pls_golite062009
oxidoreductase activity 0.88505980389015 bayes_pls_golite062009
hexosaminidase activity 0.763360027922833 bayes_pls_golite062009
substrate-specific channel activity 0.7468694373149 bayes_pls_golite062009
channel activity 0.72022399139884 bayes_pls_golite062009
passive transmembrane transporter activity 0.72022399139884 bayes_pls_golite062009
carbohydrate binding 0.66542913126194 bayes_pls_golite062009
binding 0.63693798355947 bayes_pls_golite062009
voltage-gated cation channel activity 0.607543065522144 bayes_pls_golite062009
sugar binding 0.52048704356718 bayes_pls_golite062009
alpha-glucosidase activity 0.502835520523619 bayes_pls_golite062009
chitinase activity 0.500233744020165 bayes_pls_golite062009
voltage-gated channel activity 0.469037239588056 bayes_pls_golite062009
voltage-gated ion channel activity 0.432338683948607 bayes_pls_golite062009
transferase activity, transferring hexosyl groups 0.266938437560648 bayes_pls_golite062009
beta-N-acetylhexosaminidase activity 0.263065978664289 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [111-444]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RNDNEKLETT RKYYFVALPM LYINDQFLPL NSIALQSVVS KWLGSDWEPI LSKIAAKNYN  60
   61 MVHFTPLQER GESNSPYSIY DQLQFDQEHF KSPEDVKNLV EHIHRDLNML SLTDIVFNHT 120
  121 ANNSPWLVEH PEAGYNHITA PHLISAIELD QELLNFSRNL KSWGYPTELK NIEDLFKIMD 180
  181 GIKVHVLGSL KLWEYYAVNV QTALRDIKAH WNDESNESYS FPENIKDISS DFVKLASFVK 240
  241 DNVTEPNFGT LGERNSNRIN VPKFIQLLKL INDGGSDDSE SSLATAQNIL NEVNLPLYRE 300
  301 YDDDVSEILE QLFNRIKYLR LDDGGPKQGP VTVD

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 87.522879
Match: 1j0hA_
Description: Neopullulanase, central domain; Neopullulanase
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [445-539]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VPLTEPYFTR FKGKDGTDYA LANNGWIWNG NPLVDFASQN SRAYLRREVI VWGDCVKLRY  60
   61 GKSPEDSPYL WERMSKYIEM NAKIFDGFRI DNCHS

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.575 d.109.1 Actin depolymerizing proteins
View Download 0.484 a.4.6 C-terminal effector domain of the bipartite response regulators
View Download 0.510 f.14.1 Voltage-gated potassium channels
View Download 0.462 d.52.3 Prokaryotic type KH domain (KH-domain type II)
View Download 0.472 d.141.1 Ribosomal protein L6
View Download 0.454 d.52.5 Probable GTPase Der, C-terminal domain
View Download 0.452 d.58.44 Multidrug efflux transporter AcrB pore domain; PN1, PN2, PC1 and PC2 subdomains
View Download 0.431 d.129.1 TATA-box binding protein-like
View Download 0.425 d.141.1 Ribosomal protein L6
View Download 0.425 d.58.20 NAD-binding domain of HMG-CoA reductase
View Download 0.376 a.156.1 S13-like H2TH domain
View Download 0.372 a.130.1 Chorismate mutase II
View Download 0.370 a.60.9 lambda integrase-like, N-terminal domain
View Download 0.361 d.56.1 GroEL-intermediate domain like
View Download 0.351 d.58.49 YajQ-like
View Download 0.350 a.29.4 RecG, N-terminal domain
View Download 0.314 d.58.7 RNA-binding domain, RBD
View Download 0.311 d.101.1 Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domains 2 and 5
View Download 0.310 d.109.1 Actin depolymerizing proteins
View Download 0.302 d.58.7 RNA-binding domain, RBD
View Download 0.294 d.58.44 Multidrug efflux transporter AcrB pore domain; PN1, PN2, PC1 and PC2 subdomains
View Download 0.278 d.110.4 SNARE-like
View Download 0.273 c.44.2 Enzyme IIB-cellobiose
View Download 0.269 a.29.2 Bromodomain
View Download 0.261 a.60.2 RuvA domain 2-like
View Download 0.258 c.47.1 Thioredoxin-like
View Download 0.222 b.40.4 Nucleic acid-binding proteins
View Download 0.218 a.118.11 Cytochrome c oxidase subunit E
View Download 0.212 d.52.3 Prokaryotic type KH domain (KH-domain type II)
View Download 0.211 d.80.1 Tautomerase/MIF
View Download 0.211 a.36.1 Signal peptide-binding domain
View Download 0.208 a.90.1 Transcription factor STAT-4 N-domain
View Download 0.201 d.58.17 Metal-binding domain

Predicted functions:

Term Confidence Notes
hydrolase activity, hydrolyzing O-glycosyl compounds 4.01411696184454 bayes_pls_golite062009
hydrolase activity, acting on glycosyl bonds 3.75569329586306 bayes_pls_golite062009
hydrolase activity 3.09437610147873 bayes_pls_golite062009
catalytic activity 1.71182498300466 bayes_pls_golite062009
cation transmembrane transporter activity 1.47858966054862 bayes_pls_golite062009
glucosidase activity 1.43091142767978 bayes_pls_golite062009
ion transmembrane transporter activity 1.20132615047656 bayes_pls_golite062009
alpha-amylase activity 0.941347702703202 bayes_pls_golite062009
oxidoreductase activity 0.903068069820964 bayes_pls_golite062009
amylase activity 0.891520642245226 bayes_pls_golite062009
phosphorylase activity 0.800923094114415 bayes_pls_golite062009
binding 0.714691332987919 bayes_pls_golite062009
cation channel activity 0.687664373378757 bayes_pls_golite062009
ligand-gated ion channel activity 0.644476237009351 bayes_pls_golite062009
ligand-gated channel activity 0.644476237009351 bayes_pls_golite062009
gated channel activity 0.639690382658596 bayes_pls_golite062009
ion channel activity 0.554120053171305 bayes_pls_golite062009
carbohydrate binding 0.504948074246922 bayes_pls_golite062009
substrate-specific channel activity 0.41159587344266 bayes_pls_golite062009
channel activity 0.389778821252571 bayes_pls_golite062009
passive transmembrane transporter activity 0.389778821252571 bayes_pls_golite062009
sugar binding 0.358568008635262 bayes_pls_golite062009
hexosaminidase activity 0.276754066333854 bayes_pls_golite062009
voltage-gated cation channel activity 0.161734714032652 bayes_pls_golite062009
chitinase activity 0.0470563383739831 bayes_pls_golite062009
transferase activity, transferring hexosyl groups 0.0442793643840943 bayes_pls_golite062009
voltage-gated channel activity 0.0360180230561171 bayes_pls_golite062009
alpha-glucosidase activity 0.0243149684125608 bayes_pls_golite062009

Predicted Domain #4
Region A:
Residues: [540-812]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TPIHVGEYFL DLARKYNPNL YVVAELFSGS ETLDCLFVER LGISSLIREA MQAWSEEELS  60
   61 RLVHKHGGRP IGSYKFVPMD DFSYPADINL NEEHCFNDSN DNSIRCVSEI MIPKILTATP 120
  121 PHALFMDCTH DNETPFEKRT VEDTLPNAAL VALCSSAIGS VYGYDEIFPH LLNLVTEKRH 180
  181 YDISTPTGSP SIGITKVKAT LNSIRTSIGE KAYDIEDSEM HVHHQGQYIT FHRMDVKSGK 240
  241 GWYLIARMKF SDNDDPNETL PPVVLNQSTC SLR

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #5
Region A:
Residues: [813-927]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FSYALERVGD EIPNDDKFIK GIPTKLKELE GFDISYDDSK KISTIKLPNE FPQGSIAIFE  60
   61 TQQNGVDESL DHFIRSGALK ATSSLTLESI NSVLYRSEPE EYDVSAGEGG AYIIP

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.408 c.2.1 NAD(P)-binding Rossmann-fold domains
View Download 0.440 b.1.18 E set domains
View Download 0.567 d.82.2 Frataxin-like
View Download 0.481 b.3.3 VHL
View Download 0.354 a.1.1 Globin-like
View Download 0.279 a.45.1 Glutathione S-transferase (GST), C-terminal domain
View Download 0.278 d.87.1 FAD/NAD-linked reductases, dimerisation (C-terminal) domain
View Download 0.264 d.110.3 PYP-like sensor domain (PAS domain)
View Download 0.250 d.110.4 SNARE-like
View Download 0.213 a.74.1 Cyclin-like

Predicted functions:

Term Confidence Notes
hydrolase activity, hydrolyzing O-glycosyl compounds 3.49882811932206 bayes_pls_golite062009
hydrolase activity, acting on glycosyl bonds 3.13521240810366 bayes_pls_golite062009
hydrolase activity 2.32639760387397 bayes_pls_golite062009
trehalase activity 1.57673904073206 bayes_pls_golite062009
catalytic activity 1.16285856935495 bayes_pls_golite062009
binding 1.09827656713171 bayes_pls_golite062009
alpha,alpha-trehalase activity 0.711518852337884 bayes_pls_golite062009
phosphorylase activity 0.60780059000187 bayes_pls_golite062009
protein binding 0.31260719357226 bayes_pls_golite062009
intramolecular oxidoreductase activity 0.0683547784833305 bayes_pls_golite062009

Predicted Domain #6
Region A:
Residues: [928-1536]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NFGKPVYCGL QGWVSVLRKI VFYNDLAHPL SANLRNGHWA LDYTISRLNY YSDEAGINEV  60
   61 QNWLRSRFDR VKKLPSYLVP SYFALIIGIL YGCCRLKAIQ LMSRNIGKST LFVQSLSMTS 120
  121 IQMVSRMKST SILPGENVPS MAAGLPHFSV NYMRCWGRDV FISLRGMLLT TGRFDEAKAH 180
  181 ILAFAKTLKH GLIPNLLDAG RNPRYNARDA AWFFLQAVQD YVYIVPDGEK ILQEQVTRRF 240
  241 PLDDTYIPVD DPRAFSYSST LEEIIYEILS RHAKGIKFRE ANAGPNLDRV MTDKGFNVEI 300
  301 HVDWSTGLIH GGSQYNCGTW MDKMGESEKA GSVGIPGTPR DGAAIEINGL LKSALRFVIE 360
  361 LKNKGLFKFS DVETQDGGRI DFTEWNQLLQ DNFEKRYYVP EDPSQDADYD VSAKLGVNRR 420
  421 GIYRDLYKSG KPYEDYQLRP NFAIAMTVAP ELFVPEHAIK AITIADEVLR GPVGMRTLDP 480
  481 SDYNYRPYYN NGEDSDDFAT SKGRNYHQGP EWVWLYGYFL RAFHHFHFKT SPRCQNAAKE 540
  541 KPSSYLYQQL YYRLKGHRKW IFESVWAGLT ELTNKDGEVC NDSSPTQAWS SACLLDLFYD 600
  601 LWDAYEDDS

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle