| Protein: | HOS1 |
| Organism: | Saccharomyces cerevisiae |
| Length: | 470 amino acids |
| Reference: | Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076 |
Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for HOS1.
| Description | E-value | Query Range |
Subject Range |
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0.0 | [88..453] | [5..389] |
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0.0 | [88..453] | [5..389] |
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0.0 | [88..453] | [5..389] |
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0.0 | [88..452] | [5..388] |
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0.0 | [86..452] | [3..388] |
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0.0 | [86..463] | [1..398] |
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Region A: Residues: [1-74] |
1 11 21 31 41 51
| | | | | |
1 MSKLVISTSI FQSQVADLLP CNNHQKSQLT YSLINAYDLL QHFDEVLTFP YARKDDLLEF 60
61 HSKSYIDYLI NGRF
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| Detection Method: |  |
Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.
| MCM Score |
SCOP Match |
SCOP Description | ||
| View | Download | 0.544 | a.28.1 | ACP-like |
| View | Download | 0.760 | a.13.1 | alpha-2-Macroglobulin receptor associated protein (RAP) domain 1 |
| View | Download | 0.719 | a.24.7 | FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP) |
| View | Download | 0.566 | a.12.1 | Kix domain of CBP (creb binding protein) |
| View | Download | 0.743 | a.76.1 | Iron-dependent represor protein, dimerization domain |
| View | Download | 0.523 | a.4.5 | "Winged helix" DNA-binding domain |
| View | Download | 0.516 | a.4.9 | Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3 |
| View | Download | 0.494 | a.5.2 | UBA-like |
| View | Download | 0.484 | a.24.17 | Group V grass pollen allergen |
| View | Download | 0.451 | a.112.1 | Description not found. |
| View | Download | 0.433 | a.64.1 | Saposin |
| View | Download | 0.413 | a.5.6 | Hypothetical protein MTH1615 |
| View | Download | 0.377 | a.48.3 | Conserved domain common to transcription factors TFIIS, elongin A, CRSP70 |
| View | Download | 0.368 | a.24.13 | Domain of the SRP/SRP receptor G-proteins |
| View | Download | 0.364 | a.23.1 | HSC20 (HSCB), C-terminal oligomerisation domain |
| View | Download | 0.341 | a.8.1 | Bacterial immunoglobulin/albumin-binding domains |
| View | Download | 0.339 | a.7.7 | BAG domain |
| View | Download | 0.329 | a.30.2 | Homodimeric domain of signal transducing histidine kinase |
| View | Download | 0.325 | a.60.1 | SAM/Pointed domain |
| View | Download | 0.308 | a.22.1 | Histone-fold |
| View | Download | 0.303 | a.30.1 | ROP protein |
| View | Download | 0.300 | d.43.1 | Elongation factor Ts (EF-Ts), dimerisation domain |
| View | Download | 0.299 | a.27.1 | Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases |
| View | Download | 0.298 | a.39.1 | EF-hand |
| View | Download | 0.296 | a.24.13 | Domain of the SRP/SRP receptor G-proteins |
| View | Download | 0.281 | a.2.3 | Chaperone J-domain |
| View | Download | 0.268 | a.60.11 | Hypothetical protein YjbJ |
| View | Download | 0.265 | a.2.10 | Epsilon subunit of F1F0-ATP synthase C-terminal domain |
| View | Download | 0.257 | a.3.1 | Cytochrome c |
| View | Download | 0.252 | f.13.1 | Family A G protein-coupled receptor-like |
| View | Download | 0.245 | a.24.3 | Cytochromes |
| View | Download | 0.245 | a.24.3 | Cytochromes |
| View | Download | 0.238 | a.28.2 | Colicin E immunity proteins |
| View | Download | 0.238 | a.2.11 | Fe,Mn superoxide dismutase (SOD), N-terminal domain |
| View | Download | 0.232 | a.7.1 | Spectrin repeat |
| View | Download | 0.229 | a.68.1 | Wiscott-Aldrich syndrome protein, WASP, C-terminal domain |
| View | Download | 0.223 | a.80.1 | DNA polymerase III clamp loader subunits, C-terminal domain |
| View | Download | 0.221 | a.144.1 | PABC (PABP) domain |
| View | Download | 0.217 | a.39.1 | EF-hand |
| View | Download | 0.217 | a.4.1 | Homeodomain-like |
| View | Download | 0.211 | a.16.1 | S15/NS1 RNA-binding domain |
| View | Download | 0.201 | a.7.8 | GAT domain |
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Region A: Residues: [75-238] |
1 11 21 31 41 51
| | | | | |
1 NKMMAQDVNN PMVESKWSEL SELADNWNEK IDYNPSQDLQ RFTTRENLYN YYLNHSQALE 60
61 NNMDCINNSE VPTNDKPTDT YILNSETKQY NLEGDCPIFS YLPMYCQVIT GATLNLLDHL 120
121 SPTERLIGIN WDGGRHHAFK QRASGFCYIN DVVLLIQRLR KAKL
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| Detection Method: | |
| Confidence: | 280.228787 |
| Match: | 1c3pA_ |
| Description: | HDAC homologue |
Matching Structure (courtesy of the PDB): |
|
| Term | Confidence | Notes |
| protein deacetylase activity | 12.8220438463909 | bayes_pls_golite062009 |
| histone deacetylase activity | 12.6231784270509 | bayes_pls_golite062009 |
| deacetylase activity | 11.5037545953213 | bayes_pls_golite062009 |
| hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides | 9.39837596691907 | bayes_pls_golite062009 |
| hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds | 9.35288901670927 | bayes_pls_golite062009 |
| NAD-dependent protein deacetylase activity | 3.35999169984456 | bayes_pls_golite062009 |
| NAD-dependent histone deacetylase activity | 3.35999169984456 | bayes_pls_golite062009 |
| transcription regulator activity | 3.05701986980927 | bayes_pls_golite062009 |
| hydrolase activity | 2.48411098726406 | bayes_pls_golite062009 |
| histone methyltransferase activity (H3-K27 specific) | 2.32426965373744 | bayes_pls_golite062009 |
| histone deacetylase activity (H3-K16 specific) | 2.32426965373744 | bayes_pls_golite062009 |
| transcription factor binding | 2.19991964087943 | bayes_pls_golite062009 |
| nucleic acid binding | 2.09632179671955 | bayes_pls_golite062009 |
| DNA binding | 1.982290944939 | bayes_pls_golite062009 |
| binding | 1.948738669065 | bayes_pls_golite062009 |
| transcription repressor activity | 1.86169983561723 | bayes_pls_golite062009 |
| protein binding | 1.77599011146146 | bayes_pls_golite062009 |
| catalytic activity | 1.68836803454021 | bayes_pls_golite062009 |
| transcription activator activity | 1.31578100431097 | bayes_pls_golite062009 |
| transcription factor activity | 1.24596588472933 | bayes_pls_golite062009 |
| transcription cofactor activity | 0.84972377395539 | bayes_pls_golite062009 |
| transcription corepressor activity | 0.75415729284699 | bayes_pls_golite062009 |
| hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines | 0.436815987851993 | bayes_pls_golite062009 |
| specific transcriptional repressor activity | 0.23239615682673 | bayes_pls_golite062009 |
| tubulin deacetylase activity | 0.12704421781224 | bayes_pls_golite062009 |
| chromatin binding | 0.104097933861351 | bayes_pls_golite062009 |
|
Region A: Residues: [239-470] |
1 11 21 31 41 51
| | | | | |
1 NKITYVDFDL HHGDGVEKAF QYSKQIQTIS VHLYEPGFFP GTGSLSDSRK DKNVVNIPLK 60
61 HGCDDNYLEL IASKIVNPLI ERHEPEALII ECGGDGLLGD RFNEWQLTIR GLSRIIINIM 120
121 KSYPRAHIFL LGGGGYNDLL MSRFYTYLTW CVTKQFSNLR CGDNNSFQID PFDVCDGDDS 180
181 EQFIREHDLV EMYNEENYQY WIYEMEGSSR MKMLRNDNKD RDMVELMKFY EL
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| Detection Method: | |
| Confidence: | 280.228787 |
| Match: | 1c3pA_ |
| Description: | HDAC homologue |
| Matching Structure (courtesy of the PDB): |
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