YRC Public Data Repository - Protein Structure Prediction

Protein:	SSE1
Organism:	Saccharomyces cerevisiae
Length:	693 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SSE1.

Description	E-value	Query Range	Subject Range
HSP70_TRIRU - Heat shock 70 kDa protein OS=Trichophyton rubrum GN=HSP70 PE=2 SV=1	0.0	[1..643]	[1..610]
gi\|6969976 - gi\|6969976\|gb\|AAF34134.1\| high molecular weight heat shock protein [Malus x domestica]	0.0	[2..673]	[7..650]
gi\|26985219 - gi\|26985219\|gb\|AAN86274.1\| non-cell-autonomous heat shock cognate protein 70 [Cucurbita maxima]	0.0	[2..673]	[7..647]
gi\|2894792, gi\|1... - gi\|2894792\|gb\|AAC02807.1\| heat shock protein 70 [Cryptosporidium parvum], gi\|1616783\|gb\|AAB16853.1\| ...	0.0	[2..646]	[6..618]
HSP70_TRYCR - Heat shock 70 kDa protein OS=Trypanosoma cruzi GN=HSP70 PE=3 SV=1	0.0	[4..644]	[6..615]
HSP70_LEIDO - Heat shock 70 kDa protein OS=Leishmania donovani GN=HSP70 PE=3 SV=1	0.0	[4..645]	[6..615]
HSP7C_ICTPU - Heat shock cognate 71 kDa protein OS=Ictalurus punctatus GN=hsc70 PE=2 SV=1	0.0	[2..645]	[4..613]
gi\|33591255 - gi\|33591255\|gb\|AAF88055.2\|AF277568_1 heat shock protein 68 long form [Drosophila serrata] gi\|34420088 - gi\|34420088\|gb\|AAQ67389.1\| heat shock protein 68 long form [Drosophila birchii]	0.0	[8..668]	[1..630]
HSP70_MAIZE, HS7... - Heat shock 70 kDa protein OS=Zea mays GN=HSP70 PE=3 SV=1, (P11143) Heat shock 70 kDa protein	0.0	[2..673]	[6..645]
gi\|28279108, gi\|... - gi\|28279108\|gb\|AAH45841.1\| Heat shock protein 8 [Danio rerio], gi\|182889846\|gb\|AAI65717.1\| Hspa8 pro...	0.0	[2..646]	[4..614]

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Predicted Domain #1

Region A:
Residues: [1-174]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSTPFGLDLG NNNSVLAVAR NRGIDIVVNE VSNRSTPSVV GFGPKNRYLG ETGKNKQTSN  60
   61 IKNTVANLKR IIGLDYHHPD FEQESKHFTS KLVELDDKKT GAEVRFAGEK HVFSATQLAA 120
  121 MFIDKVKDTV KQDTKANITD VCIAVPPWYT EEQRYNIADA ARIAGLNPVR IVND

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [369-386]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DEAIAKGAAF ICAIHSPT

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	1646.9897
Match:	1hjoA_
Description:	Heat shock protein 70kDa, ATPase fragment
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
unfolded protein binding	4.93074236328581	bayes_pls_golite062009
structural molecule activity	2.37892721989886	bayes_pls_golite062009
binding	2.11855816699924	bayes_pls_golite062009
cytoskeletal protein binding	1.69431775343358	bayes_pls_golite062009
transcription regulator activity	1.68670098354938	bayes_pls_golite062009
nucleic acid binding	1.43834016708999	bayes_pls_golite062009
structural constituent of cytoskeleton	1.43110879934367	bayes_pls_golite062009
peptidase activity	1.4127499531612	bayes_pls_golite062009
carbohydrate kinase activity	1.3713660758447	bayes_pls_golite062009
DNA binding	1.36804228074586	bayes_pls_golite062009
transporter activity	1.2883466875237	bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor	1.16749728168925	bayes_pls_golite062009
kinase activity	1.11102445353265	bayes_pls_golite062009
protein binding	0.956664772028256	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	0.953663805249074	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides	0.900931843471417	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	0.898645342556399	bayes_pls_golite062009
pyrophosphatase activity	0.875671218597808	bayes_pls_golite062009
hydrolase activity	0.807017237368431	bayes_pls_golite062009
substrate-specific transporter activity	0.796517590178929	bayes_pls_golite062009
transcription factor activity	0.783439770973386	bayes_pls_golite062009
nucleoside-triphosphatase activity	0.78242344952806	bayes_pls_golite062009
protein transporter activity	0.780308299678282	bayes_pls_golite062009
ATPase activity	0.687771333492666	bayes_pls_golite062009
myosin binding	0.607451856096	bayes_pls_golite062009
hexokinase activity	0.49038289556657	bayes_pls_golite062009
catalytic activity	0.296484721581333	bayes_pls_golite062009
chromatin binding	0.155140608043269	bayes_pls_golite062009
protease binding	0.121259015422625	bayes_pls_golite062009
chaperone binding	0.00111313452804307	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [175-235]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VTAAGVSYGI FKTDLPEGEE KPRIVAFVDI GHSSYTCSIM AFKKGQLKVL GTACDKHFGG  60
   61 R

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [311-368]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KPLLERVTEP VTKALAQAKL SAEEVDFVEI IGGTTRIPTL KQSISEAFGK PLSTTLNQ

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	1646.9897
Match:	1hjoA_
Description:	Heat shock protein 70kDa, ATPase fragment
Matching Structure (courtesy of the PDB):

Predicted Domain #3

Region A:
Residues: [236-310]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DFDLAITEHF ADEFKTKYKI DIRENPKAYN RILTAAEKLK KVLSANTNAP FSVESVMNDV  60
   61 DVSSQLSREE LEELV

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	1646.9897
Match:	1hjoA_
Description:	Heat shock protein 70kDa, ATPase fragment
Matching Structure (courtesy of the PDB):

Predicted Domain #4

Region A:
Residues: [387-566]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LRVRPFKFED IHPYSVSYSW DKQVEDEDHM EVFPAGSSFP STKLITLNRT GDFSMAASYT  60
   61 DITQLPPNTP EQIANWEITG VQLPEGQDSV PVKLKLRCDP SGLHTIEEAY TIEDIEVEEP 120
  121 IPLPEDAPED AEQEFKKVTK TVKKDDLTIV AHTFGLDAKK LNELIEKENE MLAQDKLVAE 180
  181

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	77.522879
Match:	1dkyA_
Description:	DnaK
Matching Structure (courtesy of the PDB):

Predicted Domain #5

Region A:
Residues: [567-693]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TEDRKNTLEE YIYTLRGKLE EEYAPFASDA EKTKLQGMLN KAEEWLYDEG FDSIKAKYIA  60
   61 KYEELASLGN IIRGRYLAKE EEKKQAIRSK QEASQMAAMA EKLAAQRKAE AEKKEEKKDT 120
  121 EGDVDMD

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	77.522879
Match:	1dkyA_
Description:	DnaK
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: