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View Structure Prediction Details

Protein: TYE7
Organism: Saccharomyces cerevisiae
Length: 291 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for TYE7.

Description E-value Query
Range
Subject
Range
gi|151945422 - gi|151945422|gb|EDN63665.1| Ty-mediated expression protein [Saccharomyces cerevisiae YJM789]
TYE7 - Serine-rich protein that contains a basic-helix-loop-helix (bHLH) DNA binding motif; binds E-boxes o...
gi|190407638 - gi|190407638|gb|EDV10905.1| serine-rich protein TYE7 [Saccharomyces cerevisiae RM11-1a]
TYE7_YEAST - Serine-rich protein TYE7 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=TYE7 PE=1 SV=1
2.0E-50 [1..291] [1..291]
gi|38156697, gi|... - gi|38156697|ref|NP_937801.1| microphthalmia-associated transcription factor isoform 5 [Homo sapiens]...
4.0E-36 [35..291] [37..287]
gi|7688653 - gi|7688653|gb|AAF67467.1|AF145751_1 microphthalmia protein [Gallus gallus]
4.0E-36 [35..291] [37..259]
gi|50979188, gi|... - gi|50979188|ref|NP_001003337.1| microphthalmia-associated transcription factor [Canis lupus familiar...
1.0E-35 [35..291] [37..293]
gi|447739 - gi|447739|prf||1915304A nylB upstream ORF
5.0E-35 [35..291] [37..293]

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Predicted Domain #1
Region A:
Residues: [1-177]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNSILDRNVR SSETTLIKPE SEFDNWLSDE NDGASHINVN KDSSSVLSAS SSTWFEPLEN  60
   61 IISSASSSSI GSPIEDQFIS SNNEESALFP TDQFFSNPSS YSHSPEVSSS IKREEDDNAL 120
  121 SLADFEPASL QLMPNMINTD NNDDSTPLKN EIELNDSFIK TNLDAKETKK RAPRKRL

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [178-291]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TPFQKQAHNK IEKRYRININ TKIARLQQII PWVASEQTAF EVGDSVKKQD EDGAETAATT  60
   61 PLPSAAATST KLNKSMILEK AVDYILYLQN NERLYEMEVQ RLKSEIDTLK QDQK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 45.70927
Match: 1am9A_
Description: SREBP-1a
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [178-291]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TPFQKQAHNK IEKRYRININ TKIARLQQII PWVASEQTAF EVGDSVKKQD EDGAETAATT  60
   61 PLPSAAATST KLNKSMILEK AVDYILYLQN NERLYEMEVQ RLKSEIDTLK QDQK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 19.39794
Match: 1nkpA
Description: Myc prot-oncogene protein
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 5.38658950816179 bayes_pls_golite062009
DNA binding 4.94162117310222 bayes_pls_golite062009
nucleic acid binding 4.64041369991064 bayes_pls_golite062009
transcription factor activity 4.57572673546692 bayes_pls_golite062009
binding 3.81829206350975 bayes_pls_golite062009
protein binding 2.64975291677725 bayes_pls_golite062009
transcription factor binding 2.61163564741984 bayes_pls_golite062009
transcription activator activity 2.5495467409976 bayes_pls_golite062009
RNA polymerase II transcription factor activity 2.48787404513864 bayes_pls_golite062009
sequence-specific DNA binding 2.23044824326772 bayes_pls_golite062009
RNA polymerase II transcription factor activity, enhancer binding 2.07158271414494 bayes_pls_golite062009
transcription cofactor activity 1.52770895937238 bayes_pls_golite062009
promoter binding 1.21602136735201 bayes_pls_golite062009
transcription repressor activity 0.955588849035129 bayes_pls_golite062009
transcription corepressor activity 0.672485914465871 bayes_pls_golite062009
protein heterodimerization activity 0.53175615551166 bayes_pls_golite062009
structure-specific DNA binding 0.3655541712365 bayes_pls_golite062009
transcription coactivator activity 0.3513586903977 bayes_pls_golite062009
double-stranded DNA binding 0.29436315000437 bayes_pls_golite062009
protein dimerization activity 0.20674648626116 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle