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View Structure Prediction Details

Protein: LCB4
Organism: Saccharomyces cerevisiae
Length: 624 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for LCB4.

Description E-value Query
Range
Subject
Range
LCB4 - Sphingoid long-chain base kinase, responsible for synthesis of long-chain base phosphates, which fun...
LCB4_YEAST - Sphingoid long chain base kinase 4 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=LCB4 ...
0.0 [1..624] [1..624]
SPHK2_MOUSE - Sphingosine kinase 2 OS=Mus musculus GN=Sphk2 PE=1 SV=2
0.0 [99..615] [12..613]
Sk1-PA, Sk1-PB - The gene Sphingosine kinase 1 is referred to in FlyBase by the symbol Dmel\Sk1 (CG1747, FBgn0030300)...
gi|220948786 - gi|220948786|gb|ACL86936.1| Sk1-PA [synthetic construct]
5.0E-90 [135..615] [97..641]
LCB4_SCHPO - Sphingoid long chain base kinase 4 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=lcb4 PE...
SPAC4A8.07c - sphingoid long chain base (LCB) kinase
8.0E-84 [139..614] [29..451]
gi|119609799, gi... - gi|21361088|ref|NP_068807.2| sphingosine kinase 1 isoform 1 [Homo sapiens], gi|14495625|gb|AAH09419....
4.0E-81 [223..611] [25..377]

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Predicted Domain #1
Region A:
Residues: [1-160]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVVQKKLRAI LTDEGVLIKS QSHHMFNKHG QLRSGDSLSL LSCLSCLDDG TLSSDGGSFD  60
   61 EDDSLELLPL NTTIPFNRIL NAKYVNVGQK GFNNGKISSN PFQTENLSSS SENDDVENHS 120
  121 LSNDKAPVSE SQSFPKKDKW DTKTNTVKVS PDDSQDNSPS 

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [161-367]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LGIKDNQQLI ELTFAVPKGH DVIPQKLTLL IDHVSRKSRA NTGEENISSG TVEEILEKSY  60
   61 ENSKRNRSIL VIINPHGGKG TAKNLFLTKA RPILVESGCK IEIAYTKYAR HAIDIAKDLD 120
  121 ISKYDTIACA SGDGIPYEVI NGLYRRPDRV DAFNKLAVTQ LPCGSGNAMS ISCHWTNNPS 180
  181 YAALCLVKSI ETRIDLMCCS QPSYMNE

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 7.4
Match: 1kq3A
Description: Glycerol dehydrogenase
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [368-428]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 WPRLSFLSQT YGVIAESDIN TEFIRWMGPV RFNLGVAFNI IQGKKYPCEV FVKYAAKSKK  60
   61 E

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted functions:

Term Confidence Notes
kinase activity 2.76633393386992 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 2.49560915337842 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 2.43985991144271 bayes_pls_golite062009
transferase activity 1.63159199531284 bayes_pls_golite062009
catalytic activity 0.33446102778142 bayes_pls_golite062009

Predicted Domain #4
Region A:
Residues: [429-624]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LKVHFLENKD KNKGCLTFEP NPSPNSSPDL LSKNNINNST KDELSPNFLN EDNFKLKYPM  60
   61 TEPVPRDWEK MDSELTDNLT IFYTGKMPYI AKDTKFFPAA LPADGTIDLV ITDARIPVTR 120
  121 MTPILLSLDK GSHVLEPEVI HSKILAYKII PKVESGLFSV DGEKFPLEPL QVEIMPMLCK 180
  181 TLLRNGRYID TEFESM

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle