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Protein Overview: Sk1-PA, Sk1-PB

General Information:
Name(s) found: Sk1-PA / FBpp0073347 [FlyBase]
Sk1-PB / FBpp0073346 [FlyBase]
Description(s) found:
Found 35 descriptions.
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  • The gene Sphingosine kinase 1 is referred to in FlyBase by the symbol Dmel\Sk1 (CG1747, FBgn0030300). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:11336574..11340045. It has the cytological map location 10B13. There is experimental evidence that it has the molecular function</span>: D-erythro-sphingosine kinase activity. There is experimental evidence that it is involved in the biological process</span>: sphingolipid metabolic process; phosphorylation. 2 alleles are reported. No phenotypic data is available. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase]
  • The gene Sphingosine kinase 1 is referred to in FlyBase by the symbol Dmel\Sk1 (CG1747, FBgn0030300). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:11336574..11340045. It has the cytological map location 10B13. There is experimental evidence that it has the molecular function</span>: D-erythro-sphingosine kinase activity. There is experimental evidence that it is involved in the biological process</span>: sphingolipid metabolic process; phosphorylation. 2 alleles are reported. No phenotypic data is available. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 641 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: phosphorylation [IDA][NAS]
    activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway [IEA]
    sphingolipid metabolic process [IDA]
    Molecular Function: D-erythro-sphingosine kinase activity [IDA][ISS][TAS]
    diacylglycerol kinase activity [IEA][NAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTANTGTSGE NLMGNGGKTH EPSTPTSDTE VASGTPTELS EIFFVDNSRR KQSIKIQVKL  60
   61 CPEGVYLRRE TEEDDHINEQ LIRIDDIIGS RYGRRLKKRA RGGLNSCRNP NVPGQEADSE 120
  121 PDSDNSAYLY IYAYLKKEKP LRRVQTLRIL RFRSSNDYGV NLQTAEMWHH TIRKHKRGNG 180
  181 SSSPADCGKQ LLILLNPKSG SGKGRELFQK QVAPLLTEAE VQYDLQITTH PQYAKEFVRT 240
  241 RRDLLTRYSG IVVASGDGLF YEVLNGLMER MDWRRACREL PLGIIPCGSG NGLAKSVAHH 300
  301 CNEPYEPKPI LHATLTCMAG KSTPMDVVRV ELATRDKHFV MYSFLSVGWG LIADIDIESE 360
  361 RLRSIGAQRF TLWAIKRLIG LRSYKGRVSY LLGKGKKEPP VEAARELPAE STAAGIRSSL 420
  421 PLNAGEFHDL PEEEEGEAVL DGEQFADAIS LDRSVYRQHA DSWHSAMSRR TAYYSLGGPS 480
  481 MRSNRSRMSI SQRIEAANAE FAERVPTGTI PPLQMPLLSS DGWICEDGDF VMVHAAYTTH 540
  541 LSSDVFFAPE SRLDDGLIYL VIIRRGVSRH QLLNFMLNLN AGTHLPIGED PFIKVVPCRA 600
  601 FRIEPSSSDG ILVVDGERVE YGPIQAEVMP GLINVMTTSG Q

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..178] PSI-BLAST 7.30103 Solution Structure of The C1 Domain of The Human Diacylglycerol Kinase Delta
    2 View Details [179..512] PSI-BLAST 38.69897 No description for 2jgrA was found.
    3 View Details [513..641] FFAS03 2.75 No description for 2bonA was found.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • binding
    		•  1.01489434558857 bayes_pls_golite062009
  • protein binding
    		•  0.595458677481796 bayes_pls_golite062009
  • catalytic activity
    		•  0.564904183614451 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  0.509180585718177 bayes_pls_golite062009
  • kinase activity
    		•  0.502413328106933 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.416811228361087 bayes_pls_golite062009
  • transferase activity
    		•  0.255707908488426 bayes_pls_golite062009
  • protein kinase activity
    		•  0.197456871880971 bayes_pls_golite062009
    2
    Term Confidence Notes
  • kinase activity
    		•  1.93010589087203 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  1.6993468998669 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  1.62136531467279 bayes_pls_golite062009
  • transferase activity
    		•  1.1287574677626 bayes_pls_golite062009
  • catalytic activity
    		•  0.704900964793432 bayes_pls_golite062009
    3 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.94

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle