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View Structure Prediction Details

Protein: LCB4
Organism: Saccharomyces cerevisiae
Length: 624 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for LCB4.

Description E-value Query
Range
Subject
Range
LCB4 - Sphingoid long-chain base kinase, responsible for synthesis of long-chain base phosphates, which fun...
LCB4_YEAST - Sphingoid long chain base kinase 4 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=LCB4 ...
0.0 [1..624] [1..624]
SPHK2_MOUSE - Sphingosine kinase 2 OS=Mus musculus GN=Sphk2 PE=1 SV=2
0.0 [99..615] [12..613]
Sk1-PA, Sk1-PB - The gene Sphingosine kinase 1 is referred to in FlyBase by the symbol Dmel\Sk1 (CG1747, FBgn0030300)...
gi|220948786 - gi|220948786|gb|ACL86936.1| Sk1-PA [synthetic construct]
5.0E-90 [135..615] [97..641]
LCB4_SCHPO - Sphingoid long chain base kinase 4 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=lcb4 PE...
SPAC4A8.07c - sphingoid long chain base (LCB) kinase
8.0E-84 [139..614] [29..451]
gi|119609799, gi... - gi|21361088|ref|NP_068807.2| sphingosine kinase 1 isoform 1 [Homo sapiens], gi|14495625|gb|AAH09419....
4.0E-81 [223..611] [25..377]

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Predicted Domain #1
Region A:
Residues: [1-160]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVVQKKLRAI LTDEGVLIKS QSHHMFNKHG QLRSGDSLSL LSCLSCLDDG TLSSDGGSFD  60
   61 EDDSLELLPL NTTIPFNRIL NAKYVNVGQK GFNNGKISSN PFQTENLSSS SENDDVENHS 120
  121 LSNDKAPVSE SQSFPKKDKW DTKTNTVKVS PDDSQDNSPS 

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [161-367]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LGIKDNQQLI ELTFAVPKGH DVIPQKLTLL IDHVSRKSRA NTGEENISSG TVEEILEKSY  60
   61 ENSKRNRSIL VIINPHGGKG TAKNLFLTKA RPILVESGCK IEIAYTKYAR HAIDIAKDLD 120
  121 ISKYDTIACA SGDGIPYEVI NGLYRRPDRV DAFNKLAVTQ LPCGSGNAMS ISCHWTNNPS 180
  181 YAALCLVKSI ETRIDLMCCS QPSYMNE

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 7.4
Match: 1kq3A
Description: Glycerol dehydrogenase
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [368-428]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 WPRLSFLSQT YGVIAESDIN TEFIRWMGPV RFNLGVAFNI IQGKKYPCEV FVKYAAKSKK  60
   61 E

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.329 d.230.3 Amyloid beta a4 protein copper binding domain (domain 2)
View Download 0.310 d.80.1 Tautomerase/MIF
View Download 0.292 d.58.48 MTH1187-like
View Download 0.499 d.52.5 Probable GTPase Der, C-terminal domain
View Download 0.383 d.47.1 Ribosomal protein L11, N-terminal domain
View Download 0.289 a.16.1 S15/NS1 RNA-binding domain
View Download 0.282 a.2.2 Ribosomal protein L29 (L29p)
View Download 0.280 d.52.3 Prokaryotic type KH domain (KH-domain type II)
View Download 0.276 d.58.11 EF-G/eEF-2 domains III and V
View Download 0.276 g.59.1 Zinc-binding domain of translation initiation factor 2 beta
View Download 0.262 g.57.1 Serine proteinase inhibitor lekti
View Download 0.239 d.109.1 Actin depolymerizing proteins

Predicted functions:

Term Confidence Notes
kinase activity 2.76633393386992 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 2.49560915337842 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 2.43985991144271 bayes_pls_golite062009
transferase activity 1.63159199531284 bayes_pls_golite062009
catalytic activity 0.33446102778142 bayes_pls_golite062009

Predicted Domain #4
Region A:
Residues: [429-624]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LKVHFLENKD KNKGCLTFEP NPSPNSSPDL LSKNNINNST KDELSPNFLN EDNFKLKYPM  60
   61 TEPVPRDWEK MDSELTDNLT IFYTGKMPYI AKDTKFFPAA LPADGTIDLV ITDARIPVTR 120
  121 MTPILLSLDK GSHVLEPEVI HSKILAYKII PKVESGLFSV DGEKFPLEPL QVEIMPMLCK 180
  181 TLLRNGRYID TEFESM

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle