YRC Public Data Repository - Protein Structure Prediction

Protein:	ADE2
Organism:	Saccharomyces cerevisiae
Length:	571 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ADE2.

Description	E-value	Query Range	Subject Range
gi\|151945749 - gi\|151945749\|gb\|EDN63990.1\| phosphoribosylaminoimidazole carboxylase [Saccharomyces cerevisiae YJM78... gi\|195972362 - gi\|195972362\|gb\|ACG61339.1\| ADE-1 [Expression vector pYAA-ZP-MCS] gi\|3243009 - gi\|3243009\|gb\|AAC23867.1\| phosphoribosylaminoimidazole carboxylase [Expression vector pBEVY-A] gi\|3243012 - gi\|3243012\|gb\|AAC23869.1\| phosphoribosylaminoimidazole carboxylase [Expression vector pBEVY-GA] gi\|3243116 - gi\|3243116\|gb\|AAC40224.1\| phosphoribosylamino-imidazole-carboxylase [Integrating expression vector Y... gi\|38327510 - gi\|38327510\|gb\|AAR17787.1\| phosphoribosylamino-imidazole-carboxylase [Cloning vector pPGA89] PUR6_YEAST - Phosphoribosylaminoimidazole carboxylase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN... ADE2 - Phosphoribosylaminoimidazole carboxylase, catalyzes a step in the 'de novo' purine nucleotide biosyn...	0.0	[1..571]	[1..571]
gi\|1813614 - gi\|1813614\|gb\|AAC49742.1\| phosphoribosylaminoimidazole carboxylase [Candida albicans]	0.0	[1..571]	[1..565]
PUR6_CANGA - Phosphoribosylaminoimidazole carboxylase OS=Candida glabrata GN=ADE2 PE=3 SV=2 PUR6_CANGA - Phosphoribosylaminoimidazole carboxylase OS=Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 ...	0.0	[1..571]	[1..570]
PUR6_SCHOC - Phosphoribosylaminoimidazole carboxylase OS=Schwanniomyces occidentalis GN=ADE2 PE=3 SV=1	0.0	[1..567]	[1..557]
gi\|6018748, gi\|1... - gi\|6018748\|emb\|CAB57994.1\| phosphoribosylaminoimidazole carboxylase [Zygosaccharomyces rouxii], gi\|2... gi\|254585243 - gi\|254585243\|ref\|XP_002498189.1\| ZYRO0G04400p [Zygosaccharomyces rouxii] gi\|146189516 - gi\|146189516\|emb\|CAM91751.1\| phosphoribosylaminoimidazole carboxylase [Cloning vector pZCAA] gi\|146189499 - gi\|146189499\|emb\|CAM91225.1\| phosphoribosylaminoimidazole carboxylase [Cloning vector pZEA]	0.0	[1..568]	[1..567]
gi\|18482492 - gi\|18482492\|gb\|AAL68881.1\| phosphoribosylaminoimidazole carboxylase [Dipodascus magnusii]	0.0	[1..571]	[1..581]
PUR6_SCHPO - Phosphoribosylaminoimidazole carboxylase OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=a... ade6 - phosphoribosylaminoimidazole carboxylase Ade6	0.0	[1..567]	[1..550]
PUR6_PICME - Phosphoribosylaminoimidazole carboxylase OS=Pichia methanolica GN=ADE1 PE=3 SV=1 PUR6_OGAME - Phosphoribosylaminoimidazole carboxylase OS=Ogataea methanolica GN=ADE1 PE=3 SV=1	0.0	[1..535]	[1..534]

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Predicted Domain #1

Region A:
Residues: [1-122]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDSRTVGILG GGQLGRMIVE AANRLNIKTV ILDAENSPAK QISNSNDHVN GSFSNPLDIE  60
   61 KLAEKCDVLT IEIEHVDVPT LKNLQVKHPK LKIYPSPETI RLIQDKYIQK EHLIKNGIAV 120
  121 TQ

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	342.917458
Match:	1b6rA_
Description:	N5-carboxyaminoimidazole ribonucleotide synthetase PurK (AIRC), C-domain; N5-carboxyaminoimidazole ribonucleotide synthetase PurK (AIRC), N-domain; N5-carboxyaminoimidazole ribonucleotide synthetase PurK (AIRC), domain 2
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
phosphoribosylaminoimidazole carboxylase activity	8.30252180826751	bayes_pls_golite062009
carboxy-lyase activity	4.46679646341684	bayes_pls_golite062009
ligase activity, forming carbon-nitrogen bonds	2.99262646198755	bayes_pls_golite062009
carbamoyl-phosphate synthase activity	2.80055235272563	bayes_pls_golite062009
carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity	2.72231827182887	bayes_pls_golite062009
catalytic activity	1.681309422157	bayes_pls_golite062009
phosphoribosylamine-glycine ligase activity	1.37477732460326	bayes_pls_golite062009
phosphoribosylaminoimidazolecarboxamide formyltransferase activity	1.20917335424321	bayes_pls_golite062009
ligase activity	1.13657217096051	bayes_pls_golite062009
carbon-nitrogen ligase activity, with glutamine as amido-N-donor	1.11645327303429	bayes_pls_golite062009
methyltransferase activity	1.01641658620582	bayes_pls_golite062009
transferase activity, transferring one-carbon groups	0.94663663480966	bayes_pls_golite062009
acid-amino acid ligase activity	0.730894973410499	bayes_pls_golite062009
hydroxymethyl-, formyl- and related transferase activity	0.56822429064158	bayes_pls_golite062009
binding	0.552939485505354	bayes_pls_golite062009
carbon-oxygen lyase activity, acting on phosphates	0.344740566585736	bayes_pls_golite062009
protein binding	0.259473641428437	bayes_pls_golite062009
glycine hydroxymethyltransferase activity	0.258234666901931	bayes_pls_golite062009
glutathione synthase activity	0.0685848191991462	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [123-185]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SVPVEQASET SLLNVGRDLG FPFVLKSRTL AYDGRGNFVV KNKEMIPEAL EVLKDRPLYA  60
   61 EKW

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	342.917458
Match:	1b6rA_
Description:	N5-carboxyaminoimidazole ribonucleotide synthetase PurK (AIRC), C-domain; N5-carboxyaminoimidazole ribonucleotide synthetase PurK (AIRC), N-domain; N5-carboxyaminoimidazole ribonucleotide synthetase PurK (AIRC), domain 2
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
phosphoribosylaminoimidazole carboxylase activity	12.126616405613	bayes_pls_golite062009
carboxy-lyase activity	8.23768576957333	bayes_pls_golite062009
carbon-carbon lyase activity	2.36590642968819	bayes_pls_golite062009
catalytic activity	1.94758748334979	bayes_pls_golite062009
lyase activity	0.685887227538264	bayes_pls_golite062009

Predicted Domain #3

Region A:
Residues: [186-393]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 APFTKELAVM IVRSVNGLVF SYPIVETIHK DNICDLCYAP ARVPDSVQLK AKLLAENAIK  60
   61 SFPGCGIFGV EMFYLETGEL LINEIAPRPH NSGHYTIDAC VTSQFEAHLR SILDLPMPKN 120
  121 FTSFSTITTN AIMLNVLGDK HTKDKELETC ERALATPGSS VYLYGKESRP NRKVGHINII 180
  181 ASSMAECEQR LNYITGRTDI PIKISVAQ

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	342.917458
Match:	1b6rA_
Description:	N5-carboxyaminoimidazole ribonucleotide synthetase PurK (AIRC), C-domain; N5-carboxyaminoimidazole ribonucleotide synthetase PurK (AIRC), N-domain; N5-carboxyaminoimidazole ribonucleotide synthetase PurK (AIRC), domain 2
Matching Structure (courtesy of the PDB):

Predicted Domain #4

Region A:
Residues: [394-571]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KLDLEAMVKP LVGIIMGSDS DLPVMSAACA VLKDFGVPFE VTIVSAHRTP HRMSAYAISA  60
   61 SKRGIKTIIA GAGGAAHLPG MVAAMTPLPV IGVPVKGSCL DGVDSLHSIV QMPRGVPVAT 120
  121 VAINNSTNAA LLAVRLLGAY DSSYTTKMEQ FLLKQEEEVL VKAQKLETVG YEAYLENK

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	304.045757
Match:	1qczA_
Description:	N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE)
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions:

Predicted functions: