YRC Public Data Repository - Protein Structure Prediction

Protein:	HST1
Organism:	Saccharomyces cerevisiae
Length:	503 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for HST1.

Description	E-value	Query Range	Subject Range
HST1 - NAD(+)-dependent histone deacetylase; essential subunit of the Sum1p/Rfm1p/Hst1p complex required fo... HST1_YEAST - NAD-dependent protein deacetylase HST1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=H... gi\|151945566 - gi\|151945566\|gb\|EDN63807.1\| conserved protein [Saccharomyces cerevisiae YJM789]	0.0	[1..503]	[1..503]
SIR2_KLULA - NAD-dependent histone deacetylase SIR2 OS=Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70... SIR2_KLULA - NAD-dependent histone deacetylase SIR2 OS=Kluyveromyces lactis GN=SIR2 PE=3 SV=2	0.0	[54..494]	[155..609]
SIR2_CANAL - NAD-dependent histone deacetylase SIR2 OS=Candida albicans GN=SIR2 PE=3 SV=1	0.0	[65..475]	[91..489]
gi\|31982681, gi\|... - gi\|31982681\|ref\|NP_071877.2\| sirtuin 2 (silent mating type information regulation 2, homolog) 2 [Mus...	4.0E-91	[150..495]	[24..362]
Sir2-PA - The gene Sir2 is referred to in FlyBase by the symbol Dmel\Sir2 (CG5216, FBgn0024291). It is a prote...	1.0E-90	[116..465]	[120..480]
SIRT2 - sirtuin (silent mating type information regulation 2 homolog) 2 (S. cerevisiae) gi\|114677027 - gi\|114677027\|ref\|XP_001168375.1\| PREDICTED: sirtuin 2 isoform 8 [Pan troglodytes]	1.0E-88	[150..495]	[24..362]

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Predicted Domain #1

Region A:
Residues: [1-145]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNILLMQRIV SFILVVSQGR YFHVGELTMT MLKRPQEEES DNNATKKLKT RLTYPCILGK  60
   61 DKVTGKFIFP AITKDDVMNA RLFLKDNDLK TFLEYFLPVE VNSIYIYFMI KLLGFDVKDK 120
  121 ELFMALNSNI TSNKERSSAE LSSIH

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

		MCM Score	SCOP Match	SCOP Description
View	Download	0.337	a.61.1	Retroviral matrix proteins
View	Download	0.205	a.80.1	DNA polymerase III clamp loader subunits, C-terminal domain
View	Download	0.337	a.61.1	Retroviral matrix proteins
View	Download	0.205	a.80.1	DNA polymerase III clamp loader subunits, C-terminal domain

Predicted Domain #2

Region A:
Residues: [146-219]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 AKAEDEDELT DPLEKKHAVK LIKDLQKAIN KVLSTRLRLP NFNTIDHFTA TLRNAKKILV  60
   61 LTGAGVSTSL GIPD

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [263-312]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PPENMYSPLH SFIKMLQDKG KLLRNYTQNI DNLESYAGID PDKLVQCHGS

[Run NCBI BLAST on this sequence.]

Region C:
Residues: [391-503]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PSRFHKTIRK DILECDLLIC IGTSLKVAPV SEIVNMVPSH VPQILINRDM VTHAEFDLNL  60
   61 LGFCDDVASL VAKKCHWDIP HKKWQDLKKI DYNCTEIDKG TYKIKKQPRK KQQ

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	475.39794
Match:	1j8fA_
Description:	Sirt2 histone deacetylase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
protein deacetylase activity	11.8771442637949	bayes_pls_golite062009
histone deacetylase activity	11.7308825525122	bayes_pls_golite062009
deacetylase activity	10.8368006972109	bayes_pls_golite062009
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	8.53375308475286	bayes_pls_golite062009
NAD-dependent protein deacetylase activity	8.13038616303736	bayes_pls_golite062009
NAD-dependent histone deacetylase activity	8.13038616303736	bayes_pls_golite062009
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	7.0185004322765	bayes_pls_golite062009
tubulin deacetylase activity	4.98963898611597	bayes_pls_golite062009
NAD+ ADP-ribosyltransferase activity	4.62921662347995	bayes_pls_golite062009
histone deacetylase activity (H3-K9 specific)	3.19556696137433	bayes_pls_golite062009
transcription regulator activity	2.9155913558118	bayes_pls_golite062009
NAD-dependent histone deacetylase activity (H4-K16 specific)	2.54548484159934	bayes_pls_golite062009
DNA binding	2.43141001866996	bayes_pls_golite062009
nucleic acid binding	2.41433477472968	bayes_pls_golite062009
transcription repressor activity	2.24657784428979	bayes_pls_golite062009
binding	2.06552694538163	bayes_pls_golite062009
NAD-independent histone deacetylase activity	2.03444106183496	bayes_pls_golite062009
transcription corepressor activity	1.64212790017753	bayes_pls_golite062009
hydrolase activity	1.43067365161346	bayes_pls_golite062009
transcription factor activity	1.30143289828088	bayes_pls_golite062009
histone deacetylase activity (H3-K14 specific)	1.2707802007556	bayes_pls_golite062009
transcription factor binding	1.14766678956419	bayes_pls_golite062009
NAD(P)+-protein-arginine ADP-ribosyltransferase activity	0.963519974868694	bayes_pls_golite062009
catalytic activity	0.739210399081789	bayes_pls_golite062009
transcription cofactor activity	0.54005617175343	bayes_pls_golite062009
protein binding	0.475479132768057	bayes_pls_golite062009
NAD-dependent histone deacetylase activity (H3-K14 specific)	0.412196364170961	bayes_pls_golite062009
NAD-dependent histone deacetylase activity (H3-K9 specific)	0.412196364170961	bayes_pls_golite062009

Predicted Domain #3

Region A:
Residues: [220-262]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FRSSEGFYSK IRHLGLEDPQ DVFNLDIFLQ DPSVFYNIAH MVL

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [313-390]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FATASCVTCH WQIPGEKIFE NIRNLELPLC PYCYQKRKQY FPMSNGNNTV QTNINFNSPI  60
   61 LKSYGVLKPD MTFFGEAL

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	475.39794
Match:	1j8fA_
Description:	Sirt2 histone deacetylase
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: