YRC Public Data Repository - Protein Structure Prediction

Protein:	PHO23
Organism:	Saccharomyces cerevisiae
Length:	330 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PHO23.

Description	E-value	Query Range	Subject Range
PHO23_YEAST - Transcriptional regulatory protein PHO23 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN... gi\|151944438 - gi\|151944438\|gb\|EDN62716.1\| phosphate metabolism-related protein [Saccharomyces cerevisiae YJM789] PHO23 - Probable component of the Rpd3 histone deacetylase complex, involved in transcriptional regulation o... gi\|190409085 - gi\|190409085\|gb\|EDV12350.1\| conserved hypothetical protein [Saccharomyces cerevisiae RM11-1a]	1.0E-63	[1..330]	[1..330]
gi\|31542998, gi\|... - gi\|31542998\|ref\|NP_076115.2\| inhibitor of growth family, member 3 [Mus musculus], gi\|26348763\|dbj\|BA...	3.0E-53	[17..330]	[1..404]
gi\|7507776 - gi\|7507776\|pir\|\|T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans	4.0E-53	[23..326]	[28..336]
JARID1C - jumonji, AT rich interactive domain 1C	1.0E-52	[23..326]	[63..371]
gi\|7108675 - gi\|7108675\|gb\|AAF36510.1\|AF132069_1 SMCX [Sus scrofa]	2.0E-46	[24..326]	[1..308]

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Predicted Domain #1

Region A:
Residues: [1-35]

      1          11         21         31         41         51         
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    1 MSSPANLFPG LNDITDVLEE FPLATSRYLT LLHEI

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [81-207]

      1          11         21         31         41         51         
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    1 PSLEEKMHVS SIMLDNLDRL TSRLELAYEV AIKNTEIPRG LRLGVDNHPA MHLHHELMEK  60
   61 IESKSNSKSS QALKSESRRE AMAANRRQGE HYSASTHQQD DSKNDANYGG SRHESQDHTG 120
  121 NNTNSRK

[Run NCBI BLAST on this sequence.]

Detection Method:	ORFEUS
Confidence:	7.33
Match:	2vsgA
Description:	Variant surface glycoprotein (N-terminal domain)
Matching Structure (courtesy of the PDB):

Predicted Domain #2

Region A:
Residues: [36-80]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DAKCVHSMPN LNERIDKFLK KDFNKDHQTQ VRLLNNINKI YEELM

[Run NCBI BLAST on this sequence.]

Detection Method:	ORFEUS
Confidence:	7.33
Match:	2vsgA
Description:	Variant surface glycoprotein (N-terminal domain)
Matching Structure (courtesy of the PDB):

Predicted Domain #3

Region A:
Residues: [208-273]

      1          11         21         31         41         51         
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    1 RANAANTNNA DPETKKRKRR VATTAVSPST ISTATAVNNG RIGTSTASRG VSSVGNSNNS  60
   61 RISRPK

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted functions:

Term	Confidence	Notes
protein deacetylase activity	7.50578521120904	bayes_pls_golite062009
histone deacetylase activity	7.35162059871663	bayes_pls_golite062009
histone acetyltransferase activity	7.10262960897544	bayes_pls_golite062009
lysine N-acetyltransferase activity	7.10262960897544	bayes_pls_golite062009
deacetylase activity	6.55925777139018	bayes_pls_golite062009
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	5.24378850198774	bayes_pls_golite062009
N-acetyltransferase activity	5.0952093808777	bayes_pls_golite062009
	4.75659254650148	bayes_pls_golite062009
N-acyltransferase activity	4.73470737654883	bayes_pls_golite062009
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	4.39452339322141	bayes_pls_golite062009
acetyltransferase activity	4.29938591960121	bayes_pls_golite062009
methylated histone residue binding	4.19057851212315	bayes_pls_golite062009
acyltransferase activity	3.59302841227183	bayes_pls_golite062009
	3.57133019761926	bayes_pls_golite062009
transferase activity, transferring acyl groups other than amino-acyl groups	3.54892905221507	bayes_pls_golite062009
transferase activity, transferring acyl groups	3.34035867339622	bayes_pls_golite062009
histone binding	3.01402804224903	bayes_pls_golite062009
binding	2.78627791259335	bayes_pls_golite062009
nucleosome binding	1.69494047037058	bayes_pls_golite062009
protein binding	1.6308789519356	bayes_pls_golite062009
chromatin binding	1.0360039180364	bayes_pls_golite062009
nucleic acid binding	1.01735624308761	bayes_pls_golite062009
DNA binding	0.896491359501813	bayes_pls_golite062009
transcription regulator activity	0.723245820583374	bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor	0.655033722565177	bayes_pls_golite062009
kinase activity	0.596989785523293	bayes_pls_golite062009
histone methyltransferase activity	0.476506467104495	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	0.465950484314184	bayes_pls_golite062009
protein kinase activity	0.405766438875014	bayes_pls_golite062009
cytoskeletal protein binding	0.327424740985033	bayes_pls_golite062009
transferase activity	0.245705939593188	bayes_pls_golite062009
histone methyltransferase activity (H3-K4 specific)	0.0490968711985191	bayes_pls_golite062009
histone acetyl-lysine binding	0.0410393640547611	bayes_pls_golite062009

Predicted Domain #4

Region A:
Residues: [274-330]

      1          11         21         31         41         51         
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    1 TNDYGEPLYC YCNQVAYGEM VGCDGADCEL EWFHLPCIGL ETLPKGKWYC DDCKKKL

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	5.69897
Match:	1f62A_
Description:	Williams-Beuren syndrome transcription factor, WSTF
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: