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View Structure Prediction Details

Protein: CWC24
Organism: Saccharomyces cerevisiae
Length: 259 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for CWC24.

Description E-value Query
Range
Subject
Range
CWC24 - Essential protein, component of a complex containing Cef1p; has similarity to S. pombe Cwf24p
gi|190405375 - gi|190405375|gb|EDV08642.1| pre-mRNA splicing factor CWC24 [Saccharomyces cerevisiae RM11-1a]
CWC24_YEAST - Pre-mRNA-splicing factor CWC24 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=CWC24 PE=...
gi|151940852 - gi|151940852|gb|EDN59234.1| complexed with cef1p [Saccharomyces cerevisiae YJM789]
gi|207342828 - gi|207342828|gb|EDZ70470.1| YLR323Cp-like protein [Saccharomyces cerevisiae AWRI1631]
1.0E-53 [1..259] [1..259]
gi|21313494, gi|... - gi|21313494|ref|NP_079801.1| ring finger protein 113A [Mus musculus], gi|12844204|dbj|BAB26275.1| un...
2.0E-53 [8..258] [48..321]
gi|208968727 - gi|208968727|dbj|BAG74202.1| ring finger protein 113B [synthetic construct]
gi|119629388, gi... - gi|14532913|emb|CAC42525.1| OTTHUMP00000018586 [Homo sapiens], gi|119629388|gb|EAX08983.1| hCG164627...
6.0E-53 [9..259] [44..316]
gi|15223384 - gi|15223384|ref|NP_171642.1| zinc finger (CCCH-type/C3HC4-type RING finger) family protein [Arabidop...
2.0E-48 [3..259] [43..337]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
4.0E-38 [5..256] [288..531]
CWC24_SCHPO - Pre-mRNA-splicing factor cwf24 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=cwf24 PE=1 ...
cwf24 - GCN5-related N acetyltransferase
4.0E-37 [2..259] [43..314]

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Predicted Domain #1
Region A:
Residues: [1-168]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MFRKRLVNKS SSDEKNQKKR QKINFSEEKL VASDEEKGSS DLMSLAKSGN SRTLQLSHEN  60
   61 EGKLQKKGED LDKYTLTVND DSTKEDLLNF ERKELAEKAK KRRPSDDNEL VLNMSGKNKR 120
  121 LTKQINQPTN IRTTVLMDFQ PDVCKDYKQT GYCGYGDSCK FLHSRDDF

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [169-259]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KTGWKLNQEW NADKEDSKAV TLDLEKIPFK CTLCKEDYKS PVVTNCGHYF CGSCFAKDMK  60
   61 KGTKCFICHK ETHGSAKVAS DLQKMLNKRK S

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 15.69897
Match: 1rmd__
Description: V(D)J recombination activating protein 1 (RAG1), dimerization domain
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [186-259]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KAVTLDLEKI PFKCTLCKED YKSPVVTNCG HYFCGSCFAK DMKKGTKCFI CHKETHGSAK  60
   61 VASDLQKMLN KRKS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 15.30103
Match: 1rmdA
Description: RAG1 DIMERIZATION DOMAIN
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
4.77196423114965 bayes_pls_golite062009
RNA binding 2.35680777511144 bayes_pls_golite062009
binding 2.19426901055464 bayes_pls_golite062009
small conjugating protein ligase activity 2.17320579037083 bayes_pls_golite062009
ligase activity 2.11117401820312 bayes_pls_golite062009
ubiquitin-protein ligase activity 2.10698039886692 bayes_pls_golite062009
transcription regulator activity 1.62076236255768 bayes_pls_golite062009
protein binding 1.34794206219054 bayes_pls_golite062009
acid-amino acid ligase activity 1.22312570999194 bayes_pls_golite062009
nucleic acid binding 1.22180889694654 bayes_pls_golite062009
DNA binding 1.00346149950987 bayes_pls_golite062009
transcription factor binding 0.39685947299825 bayes_pls_golite062009
transcription factor activity 0.382098789505496 bayes_pls_golite062009
catalytic activity 0.14112008370434 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle